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Forkhead Box L2 Proteins (FOXL2)

FOXL2 encodes a forkhead transcription factor. Additionally we are shipping FOXL2 Antibodies (99) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FOXL2 26927 O88470
Rat FOXL2 FOXL2 367152  
FOXL2 668 P58012
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Top FOXL2 Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Goat His tag   1 mg Log in to see 56 to 66 Days
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

FOXL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

More Proteins for Forkhead Box L2 (FOXL2) Interaction Partners

Zebrafish Forkhead Box L2 (FOXL2) interaction partners

  1. Data show that cytochrome P450 enzymes Cyp17 (show CYP17A1 Proteins)-I, Cyp11c1 (show CYP11B2 Proteins), Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (show FOXO4 Proteins) Foxl2a were detected both in the testis and ovary.

  2. Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).

  3. Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus

Xenopus laevis Forkhead Box L2 (FOXL2) interaction partners

  1. Xenopus W-linked DM-W induces foxl2 expression during ovary formation.

Mouse (Murine) Forkhead Box L2 (FOXL2) interaction partners

  1. Data indicate that a balance between supporting cell (show PTPRJ Proteins) self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 (show WNT4 Proteins) protein/beta-catenin (show CTNNB1 Proteins) and p27Kip1 (show CDKN1B Proteins) protein (p27 (show CDKN1B Proteins))/Forkhead box L2 (FOXL2) activities.

  2. Data indicate that the hypothalamic-pituitary-gonadal axis controls expression of Foxl2 in pituitary gonadotropes primarily through positive feedback from ovarian hormones.

  3. FOXL2 mobilizes estrogen signaling to establish a coherent feed-forward loop repressing Sox9 (show SOX9 Proteins).

  4. Foxl2 has a crucial role in postnatal uterine maturation and could help to understand sub-fertility predisposition in women.

  5. Results support FOXL2 as a master transcription factor in a spectrum of developmental processes, including growth, cartilage and bone formation. Its action overlaps that of SOX9 (show SOX9 Proteins), though they are antagonistic in female vs male gonadal sex determination but conjoint in cartilage and skeletal development.

  6. Microarray expression profiling of whole adrenal mRNA from ovariectomized vs. intact mice demonstrated selective upregulation of gonadal-like genes including Spinlw1 and Insl3 (show INSL3 Proteins) in GDX (show UBL4A Proteins)-induced adrenocortical tumors of the mouse.

  7. our results demonstrate the necessity of FOXL2 for proper FSH (show BRD2 Proteins) production in mice and implicate FOXL2 in integration of transcription factors at the level of the FSHbeta promoter.

  8. Results show that a piggyBac insertion ~160 kb upstream of the transcription start site of Foxl2 partially disrupted its expression resulting in BPES (Blepharophimosis, ptosis, epicanthus inversus syndrome)-like conditions.

  9. AMH (show AMH Proteins) is an endogenous target gene of FOXL2. AMH (show AMH Proteins) and FOXL2 collaboratively work to reserve ovarian follicles.

  10. In this review, we focus on the role of four specific FOX factors (FOXD1 (show FOXD1 Proteins), FOXL2, FOXO1 (show FOXO1 Proteins) and FOXP3 (show FOXP3 Proteins)) in gonadotropin hormone production

Human Forkhead Box L2 (FOXL2) interaction partners

  1. The absence of FOXL2 and DICER1 (show DICER1 Proteins) gene mutation observed in 3 patients, along with strong FOXL2 immunoreactivity provides additional evidence to place microcystic stromal tumor within pure gonadal stromal rather than sex cord ovarian tumors.

  2. genetic association study in two families with blepharophimosis-ptosis-epicanthus inversus syndrome type 1: Two distinct mutations, a missense p.H104R change and an in-frame p.A222_A231dup10 duplication in FOXL2 gene are identified in three women.

  3. suggests the potential of pS33 FOXL2 to serve as a new biomarker for the diagnosis of adult-type GCT (show QPCT Proteins)

  4. Our combined analysis identifies potential candidate genes, whose alterations might contribute to adult-type Ovarian granulosa cell tumors formation/progression together with the recurrent FOXL2 somatic mutation.

  5. Describe microcystic stromal tumor as a distinctive ovarian sex cord-stromal neoplasm characterized by FOXL2, SF-1 (show NR5A1 Proteins), WT-1 (show WT1 Proteins), Cyclin D1 (show CCND1 Proteins), and beta-catenin (show CTNNB1 Proteins) nuclear expression and CTNNB1 (show CTNNB1 Proteins) mutations.

  6. Foxl2 deletion in either Cranial Neural Crest Cells (CNCCs) or Cranial Mesodermal Cells (CMCs (show GPSM2 Proteins)) prevents eyelid closure and induces subtle skeletal developmental defects.

  7. C134W mutation affects granulosa cell tumor development via differential posttranslational modifications of FOXL2 by GSK3B.

  8. Two novel FOXL2 mutations (c.675_690delinsT, and p.Leu75Phe) were identified in Chinese families with blepharophimosis-ptosis-epicanthus inversus syndrome.

  9. Uterine tumors resembling ovarian sex cord tumors do not harbor FOXL2 mutation

  10. FOXL2 p.C134W mutation-positive adult-type granulosa cell tumor of the ovary may not be common in the Japanese.

Cow (Bovine) Forkhead Box L2 (FOXL2) interaction partners

FOXL2 Protein Profile

Protein Summary

This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.

Gene names and symbols associated with Forkhead Box L2 Proteins (FOXL2)

  • forkhead box L2 (FOXL2)
  • forkhead box L2 (foxl2)
  • forkhead box L2 (Foxl2)
  • FoxL protein (foxL)
  • forkhead transcription factor L2 (FoxL2)
  • foxl2 protein (foxl2)
  • fork-head box L2 transcription factor (foxL2)
  • AU045128 protein
  • BPES protein
  • BPES1 protein
  • foxL2 protein
  • PFRK protein
  • PINTO protein
  • POF3 protein
  • zgc:136549 protein

Protein level used designations for Forkhead Box L2 Proteins (FOXL2)

forkhead box L2 , forkhead box protein L2 , transcription factor FOXL2 , forkhead transcription factor L2 , foxl2 protein , fork-head box L2 transcription factor , P-Frk , pituitary forkhead factor , putative transcription factor foxl2 , forkhead transcription factor FOXL2 , Forkhead box protein L2

470940 Pan troglodytes
503512 Gallus gallus
692279 Danio rerio
100125429 Oryzias latipes
100188926 Xenopus laevis
100534517 Oreochromis niloticus
445798 Ciona intestinalis
751846 Strongylocentrotus purpuratus
100169941 Ciona intestinalis
100328989 Saccoglossus kowalevskii
26927 Mus musculus
367152 Rattus norvegicus
668 Homo sapiens
281770 Bos taurus
100687445 Canis lupus familiaris
100622956 Sus scrofa
100328926 Oryctolagus cuniculus
100750236 Capra hircus
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