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Forkhead Box P2 Proteins (FOXP2)

FOXP2 encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. Additionally we are shipping FOXP2 Antibodies (127) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FOXP2 93986 O15409
FOXP2 114142 P58463
FOXP2 500037 P0CF24
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Top FOXP2 Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

FOXP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Forkhead Box P2 (FOXP2) Interaction Partners

Human Forkhead Box P2 (FOXP2) interaction partners

  1. FOXP2 can be modified with all three human SUMO proteins and that PIAS1 (show PIAS1 Proteins) promotes this process.

  2. FOXP2 is a substrate for SUMOylation and SUMOylation of FOXP2 plays a functional role in regulating its transcriptional activity.

  3. CNTNAP2 (show CNTNAP2 Proteins) is transcriptionally regulated by FOXP2.

  4. Data suggest FOXP2 binds DNA as monomer; FOXP2 hinge loop domain mutants exhibit either decreased formation of homodimer (A539P) or decreased dissociation of homodimer (F541C); naturally occurring reverse mutation (P539A) increases DNA binding affinity.

  5. Genetic variants in FOXP2 may be significant for rare forms of language impairment, they do not contribute appreciably to individual variation in the normal range as found in the general population.

  6. Our results suggested that FOXP2 expression was downregulated in Hepatocellular carcinoma tumor tissues, and reduced FOXP2 expression was associated with poor overall survival

  7. TBR1 (show TBR1 Proteins) homodimerizes; it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein

  8. FOXF2 (show FOXF2 Proteins) deficiency enhances metastatic ability of BLBC cells by activating the EMT (show ITK Proteins) program through upregulating the transcription of TWIST1 (show TWIST1 Proteins).

  9. Random monoallelic expression impacts the haploinsufficiency phenotypes observed for FOXP2 mutations.

  10. pH had a direct effect on FOXP2 binding to DNA affinity.

Mouse (Murine) Forkhead Box P2 (FOXP2) interaction partners

  1. The Foxp2 gene is critical for normal vocal behavior in juvenile and adult mice.

  2. This study demonstrated that after middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs and suppression of the language-associated transcription factor, Forkhead box protein 2 (Foxp2).

  3. mice with Foxp2 mutations displayed quantitative differences in ultrasonic vocalizations as compared to wild-types

  4. Collectively, these findings reveal an important role for the FOXP1 (show FOXP1 Proteins), 2, and 4 proteins in governing postnatal alpha cell expansion and function.

  5. Foxp2 was elevated early after stroke (at 6h), but significantly decreased 24h after injury in both the nucleus and the cytoplasm; neuronal Foxp2 expression increased in stroke mice compared to sham animals 4 weeks after injury

  6. arkypallidal GPe neurons originate from lateral/caudal ganglionic eminences, express the transcription factor FoxP2, fire at low rates during rest, and encode movements with robust increases in firing.

  7. Foxp1 (show FOXP1 Proteins)/2/4 may regulate Runx2 (show RUNX2 Proteins) during endochondral ossification.

  8. Results suggest that Foxp2 regulates multiple aspects of neuronal development in the embryonic forebrain

  9. Foxp2 in Purkinje cells may pertain to the brain network engaged in ultrasonic vocalization (USV) modification, including USV duration, but not USV production

  10. results indicate that FOXP2 is critical for the function of striatal circuits.

Zebrafish Forkhead Box P2 (FOXP2) interaction partners

  1. Our findings suggest that foxP2 is not necessary for axon pathfinding during development.

  2. foxP2 likely has a more general conserved role in nervous system development; molecular cloning

  3. The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum.

  4. Domain-specific regulation of foxP2 CNS expression by lef1 (show LEF1 Proteins).

FOXP2 Protein Profile

Protein Summary

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Gene names and symbols associated with Forkhead Box P2 Proteins (FOXP2)

  • forkhead box P2 (FOXP2)
  • forkhead box P2 (foxp2)
  • forkhead box P2 (LOC100144325)
  • forkhead box P2 (LOC100169841)
  • forkhead box P2 (foxP2)
  • lmw-gs (Foxp2)
  • forkhead box transcription factor (foxp1c)
  • forkhead box P2 (predicted), 5 prime (FOXP2)
  • forkhead box P2 (Foxp2)
  • uncharacterized LOC505502 (LOC505502)
  • 2810043D05Rik protein
  • AI449000 protein
  • CAG-16 protein
  • CAGH44 protein
  • D0Kist7 protein
  • foxP protein
  • Foxp2 protein
  • foxp2a protein
  • foxP2b protein
  • RGD1559697 protein
  • SPCH1 protein
  • TNRC10 protein
  • xlFoxP2 protein

Protein level used designations for Forkhead Box P2 Proteins (FOXP2)

forkhead box protein P2 , transcription factor FoxP2 , forkhead box P2 , forkhead box P protein , lmw-gs , forkhead box P2 (predicted), 5 prime , forkhead box P2 (predicted), 3 prime , CAG repeat protein 44 , forkhead/winged-helix transcription factor , trinucleotide repeat containing 10 , trinucleotide repeat-containing gene 10 protein , forkhead box transcription factor , xlFoxP2

100439724 Pongo abelii
751769 Taeniopygia guttata
769935 Gallus gallus
100101742 Xenopus (Silurana) tropicalis
100137387 Papio anubis
100144325 Oryctolagus cuniculus
100169841 Oryzias latipes
100303474 Saccoglossus kowalevskii
542882 Triticum aestivum
779033 Xenopus laevis
100328793 Oryctolagus cuniculus
93986 Homo sapiens
482413 Canis lupus familiaris
100127352 Sus scrofa
114142 Mus musculus
500037 Rattus norvegicus
555242 Danio rerio
100134847 Felis catus
734154 Xenopus laevis
100990292 Pan paniscus
613237 Macaca mulatta
449627 Pan troglodytes
505502 Bos taurus
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