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Fragile Histidine Triad Proteins (FHIT)

FHIT, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Additionally we are shipping FHIT Antibodies (128) and FHIT Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FHIT 2272 P49789
FHIT 60398 Q9JIX3
FHIT 14198 O89106
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Top FHIT Proteins at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag Fragile Histidine Triad (FHIT) (AA 2-147), (full length) protein (His tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,326.50
Details

FHIT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine) ,

Top referenced FHIT Proteins

  1. Human FHIT Protein expressed in Escherichia coli (E. coli) - ABIN667000 : Hassan, Naiyer, Ahmad: Fragile histidine triad protein: structure, function, and its association with tumorogenesis. in Journal of cancer research and clinical oncology 2010 (PubMed)
    Show all 2 references for ABIN667000

More Proteins for Fragile Histidine Triad (FHIT) Interaction Partners

Human Fragile Histidine Triad (FHIT) interaction partners

  1. FHIT hypermethylation, which induces the inactivation of FHIT gene, plays an important role in the carcinogenesis and clinical outcome and may serve as a potential diagnostic marker and drug target of non-small-cell lung carcinoma

  2. Low FHIT Gene Expression is associated with Acute Lymphoblastic Leukemia.

  3. In 22 lung cancer patients with negative histology and cytology at initial bronchoscopy, FHIT and p16 mRNA loss was detected in 40.9% (9/22) and 36.4% (8/22) cases, respectively.

  4. The results showed that the methylation levels of both BRCA1 and FHIT promoters were higher in the serum of the breast ductal carcinoma group than those of the breast fibroadenoma group.

  5. Review/Meta-analysis: FHIT methylation could be a diagnostic biomarker of breast carcinogenesis.

  6. Mutations of the FHIT gene are not major cause of Peutz-Jeghers syndrome.

  7. Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins.

  8. APOBEC3B overexpression and Fhit-loss induced DNA damage are independent events that, when occurring together, result in a significantly increased frequency of APOBEC-induced mutations that drive cancer progression.

  9. Hypermethylation of FHIT gene is associated with Epstein-Barr virus-associated gastric carcinomas.

  10. FHIT promotor hypermethylation is associated with the development of breast cancer.

Mouse (Murine) Fragile Histidine Triad (FHIT) interaction partners

  1. Fhit-deficiency mutation signature also resembles a C>T and T>C mutation signature reported for human papillary kidney cancers and a similar signature recently reported for esophageal and bladder cancers, cancers that are frequently Fhit deficient.

  2. Fhit deficiency-induced global genome instability promotes mutation and clonal expansion

  3. Fhit delocalizes annexin A4 (show ANXA4 Proteins) from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

  4. FHIT gene is a "caretaker gene" necessary for maintenance of genome stability.

  5. Loss of Fhit expression contributes to cell transformation.

  6. Defects in Fhit expression may promote MHC-I down-regulation in cancer cells and allow escape from immunosurveillance.

  7. Human and mouse orthologous genes, FHIT and Fhit, are more highly conserved through evolution than PTPRG/Ptprg (show PTPRG Proteins) and yet contain more sequence elements that are exquisitely sensitive to genomic rearrangements

  8. Association of Fhit gene inactivation with increased survival after DNA damage, related to over-active checkpoints regulated by ATR/CHK1 pathway. Potential effects of Fhit-dependent DNA damage response on tumor progression.

  9. Fhit has a role in bladder cancer development

  10. UV-induced alterations of the FHIT and WWOX (show WWOX Proteins) fragile site gene expression are involved at least partially in the checkpoint function of DNA damage

Cow (Bovine) Fragile Histidine Triad (FHIT) interaction partners

  1. the same mRNA isoforms of FHIT were detected in bladder tumors and in healthy tissues, including a novel isoform that was found in this study, suggesting that epigenetic modifications and altered expression profiles are not a hallmark of vesical tumors

FHIT Protein Profile

Protein Summary

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with Fragile Histidine Triad Proteins (FHIT)

  • fragile histidine triad (FHIT)
  • fragile histidine triad (Fhit)
  • fragile histidine triad gene (Fhit)
  • fragile histidine triad gene (FHIT)
  • AP3Aase protein
  • AW045638 protein
  • FRA3B protein
  • Fra14A2 protein

Protein level used designations for Fragile Histidine Triad Proteins (FHIT)

AP3A hydrolase , bis(5'-adenosyl)-triphosphatase , diadenosine 5',5'''-P1,P3-triphosphate hydrolase , dinucleosidetriphosphatase , tumor suppressor protein , AP3Aase , fragile histidine triad protein , diadenosine triphosphate hydrolase

GENE ID SPECIES
2272 Homo sapiens
100215999 Canis lupus familiaris
60398 Rattus norvegicus
416071 Gallus gallus
14198 Mus musculus
692183 Bos taurus
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