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Fragile X Mental Retardation, Autosomal Homolog 1 Proteins (FXR1)

The protein encoded by FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. Additionally we are shipping FXR1 Antibodies (91) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FXR1 14359 Q61584
FXR1 8087 P51114
FXR1 361927 Q5XI81
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Top FXR1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,626.33
Details

FXR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,
Rat (Rattus)

More Proteins for Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) Interaction Partners

Mouse (Murine) Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) interaction partners

  1. FXR1P is a GSK3beta substrate with a role in regulating mood and emotion processing

  2. Removal of FXR1P from the forebrain of postnatal mice selectively enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation (L-LTP (show SCP2 Proteins)), and de novo GluA2 (show GRIA2 Proteins) synthesis.

  3. FXR1P was highly expressed during hippocampal development and co-localized with ribosomes and mRNAs in the dendrite and at a subset of spines.

  4. FXR1P is required for efficient processing of pre-microR-9 and pre-microR-124 in vitro and forms a complex with Dicer (show DICER1 Proteins) and pre-miRNAs.

  5. Fxr1 knockout hearts exhibit an up-regulation of desmoplakin and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart

  6. Targeting the p38 mitogen-activated protein kinase (show MAPK14 Proteins) pathway of LPS (show TLR4 Proteins)-treated cells with small molecule inhibitors can induce FXR1 protein expression.

  7. Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated (show NSDHL Proteins) muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 amino acids.

  8. FXR1P operates as a repressor of TNF (show TNF Proteins) translation

  9. the data clearly demonstrate the importance of FXR1P RBP (show RBP4 Proteins) in the regulation of a wide spectrum of inflammatory genes and suggest an important role of MAP signalling in the response of macrophages to selected TLR ligands, including CpG.

  10. Fxr1 regulates mammalian circadian behavioral rhythms.

Xenopus laevis Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) interaction partners

  1. Fxr1 plays a vital role during Xenopus embryogenesis. Knockdown of Fxr1 has highly muscle-specific (show EIF3K Proteins) effects leading to disruption of MyoD (show MYOD1 Proteins) expression, inhibition of somite myotomal cell rotation and segmentation, and abnormal dermatome formation.

Human Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) interaction partners

  1. P97 (show EIF4G2 Proteins) interacts with 3' UTR-binding FXR1a-associated microRNPs and with PARN (show PARN Proteins), which binds mRNA 5' caps (show CAPS Proteins), forming a specialized complex to translate recruited mRNAs in these altered canonical translation conditions.

  2. An accumulation of 8 SNPs in the fragile gene family (FMR1 (show FMR1 Proteins), FXR1 and FXR2 (show FXR2 Proteins))were found associated with autistic traits in a sample of male patients.

  3. FXR1P is a GSK3beta substrate with a role in regulating mood and emotion processing

  4. The mechanisms by which FXR1 executes its regulatory function by forming a novel complex with two other oncogenes, protein kinase C, iota and epithelial cell transforming 2, located in the same amplicon via distinct binding mechanisms, were identified.

  5. binding of PKP1/3 to FXR1 was RNA independent, and both PKP3 and FXR1 stabilized PKP2 mRNA.

  6. Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A (show LMNA Proteins) p.R482W mutation elicits a myogenic gene expression program in preadipocytes.

  7. findings showed that FXR1P interacts with BTF in vivo and proved that FXR1P and BTF can co-localize mainly in the cytoplasm around the nucleus

  8. FXR1 and UPF1 (show UPF1 Proteins) may have a functional role in prostate cancer progression and metastasis.

  9. Our study describes a novel role of FXR1P that has crucial implications for the understanding of its role during myogenesis and muscle development

  10. Data show that the nuclear localization signals of the FXR1 and FXR2 (show FXR2 Proteins) comprise tandem Tudor domain architectures.

FXR1 Protein Profile

Protein Summary

The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with FXR1

  • fragile X mental retardation, autosomal homolog 1 (fxr1)
  • fragile X mental retardation, autosomal homolog 1 (FXR1)
  • fragile X mental retardation gene 1, autosomal homolog (Fxr1)
  • fragile X mental retardation, autosomal homolog 1 (fxr1-a)
  • fragile X mental retardation, autosomal homolog 1 (Fxr1)
  • 1110050J02Rik protein
  • 9530073J07Rik protein
  • AI851072 protein
  • FXR1 protein
  • Fxr1h protein
  • FXR1P protein
  • wu:fb16f11 protein
  • wu:fd18c10 protein
  • xfxr1 protein
  • xFxr1p protein
  • XtFxr1p protein
  • zgc:66226 protein

Protein level used designations for FXR1

Fragile X mental retardation syndrome-related protein 1 homolog , fragile X mental retardation syndrome-related protein 1 homolog , fragile X mental retardation syndrome-related protein 1 , fragile X mental retardation, autosomal homolog 1 , fragile X mental retardation-related protein 1 , fragile X mental retardation syndrome-related protein 1-like , fragile X mental retardation gene, autosomal homolog , fragile-X-related protein 1 , mFxr1p , fragile X-related protein , FXR1 , fragile X mental retardation syndrome-related protein 1 homolog A , xFxr1p-A , hFXR1p , fragile X mental retardation gene 1, autosomal homolog

GENE ID SPECIES
594894 Xenopus (Silurana) tropicalis
710170 Macaca mulatta
746398 Pan troglodytes
100066076 Equus caballus
100172974 Pongo abelii
100340080 Oryctolagus cuniculus
100399500 Callithrix jacchus
100595780 Nomascus leucogenys
14359 Mus musculus
100689323 Cricetulus griseus
398050 Xenopus laevis
424968 Gallus gallus
8087 Homo sapiens
478642 Canis lupus familiaris
536793 Bos taurus
361927 Rattus norvegicus
100155866 Sus scrofa
327220 Danio rerio
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