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Free Fatty Acid Receptor 3 Proteins (FFAR3)

Receptor for short chain fatty acids. Additionally we are shipping FFAR3 Antibodies (36) and FFAR3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FFAR3 2865 O14843
FFAR3 365228  
FFAR3 233080 Q3UFD7
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Top FFAR3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

FFAR3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Rat (Rattus)
Mouse (Murine) ,

More Proteins for Free Fatty Acid Receptor 3 (FFAR3) Interaction Partners

Cow (Bovine) Free Fatty Acid Receptor 3 (FFAR3) interaction partners

  1. GPR41 gene contains 3 exons and its transcription is initiated at 2 leader exons, generating 2 GPR41 mRNA variants differing in the 5' untranslated region

Human Free Fatty Acid Receptor 3 (FFAR3) interaction partners

  1. Our data suggest that GPR42 be reclassified as a functioning gene and that recognition of sequence and copy number polymorphism of the FFAR3/GPR42 complex be considered during genetic and pharmacological investigation of these receptors.

  2. FFAR3 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS Proteins) secretion by coupling to Gi-type G proteins.

  3. a significant correlation between a higher body mass index and lower methylation in the promoter region of FFAR3 in type 2 diabetes and obesity patients

  4. Propionate-stimulated GPR41 strongly coupled to ERK1/2 activation, while the coupling of linoleic acid-activated GPR40 and acetate-activated GPR43 (show FFAR2 Proteins) was weaker.

  5. GPR41 activation inhibits histone acetylation and cell growth.

  6. GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins

  7. Selective orthosteric free fatty acid receptor 2 (show FFAR2 Proteins) (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

  8. characterization of GP41 in human tissue as a receptor for short chain fatty acids

  9. C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor (show GPRC5D Proteins) GPR41, stimulate leptin (show LEP Proteins) expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture

  10. GPR41 and 43 mediate SCFA signaling in mammary epithelial cells and thereby play an important role in their stress management.

Mouse (Murine) Free Fatty Acid Receptor 3 (FFAR3) interaction partners

  1. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gbetagamma-PLCbeta3-ERK1/2-synapsin 2 (show SYN2 Proteins)

  2. mediates beta cell glucose stimulated insulin (show INS Proteins) secretion through Galphai/o sensitive pathway

  3. Results indicate that FFAR3 is expressed on postganglionic sympathetic and sensory neurons in both the autonomic and somatic peripheral nervous system

  4. FFAR3 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS Proteins) secretion by coupling to Gi-type G proteins.

  5. Data from transgenic mice suggest that Ffar3/Gpr41 and Ffar2/Gpr43 (show FFAR2 Proteins) both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar3/Gpr41 appears to play this role alone in enteric neurons and Ffar2/Gpr43 (show FFAR2 Proteins) alone in enteric leukocytes.

  6. Short-chain fatty acids activate GPR41 and on intestinal epithelial cells, leading to mitogen-activated protein kinase (show MAPK1 Proteins) signaling and rapid production of chemokines and cytokines. These pathways mediate protective immunity and tissue inflammation in mice.

  7. GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins

  8. Short chain fatty acids and ketone bodies directly regulate GPR41-mediated sympathetic nervous system activity and thereby control body energy expenditure in maintaining metabolic homeostasis.

  9. Acetate and propionate short chain fatty acids may have important physiological roles in adipogenesis through GPCR43 (show FFAR2 Proteins), but not through GPCR41 (show GPR172B Proteins).

  10. Gpr41 is a regulator of host energy balance through effects that are dependent upon the gut (show GUSB Proteins) microbiota

FFAR3 Protein Profile

Protein Summary

Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5- trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate.

Gene names and symbols associated with FFAR3

  • free fatty acid receptor 3 (FFAR3)
  • free fatty acid receptor 3 (Ffar3)
  • FFA3R protein
  • Gm478 protein
  • Gpr41 protein

Protein level used designations for FFAR3

free fatty acid receptor 3 , G protein-coupled receptor 41 , G-protein coupled receptor 41 , putative G protein-coupled receptor GPR41

GENE ID SPECIES
455946 Pan troglodytes
527517 Bos taurus
612659 Canis lupus familiaris
708732 Macaca mulatta
100600134 Nomascus leucogenys
2865 Homo sapiens
365228 Rattus norvegicus
233080 Mus musculus
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