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The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Additionally we are shipping FRAT2 Proteins (3) and FRAT2 Kits (2) and many more products for this protein.
Showing 10 out of 50 products:
Human Polyclonal FRAT2 Primary Antibody for EIA, IF - ABIN952389
Liu, Zhang, Yao, Zhang, Fang, Wang, Wang: Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. in Neurobiology of aging 2008
Show all 4 references for ABIN952389
Human Polyclonal FRAT2 Primary Antibody for IF, IHC (p) - ABIN655793
Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: The DNA sequence and comparative analysis of human chromosome 10. ... in Nature 2004
Human Polyclonal FRAT2 Primary Antibody for ELISA, WB - ABIN184718
Saitoh, Moriwaki, Koike, Takagi, Miwa, Shiokawa, Katoh: Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway. in Biochemical and biophysical research communications 2001
Data show that MLL (show MLL Antibodies) fusion oncogenes maintain leukemia-associated Rac (show AKT1 Antibodies) GTPases activity by regulating Frat gene expression, specifically Frat2.
Data show that that Frat synergizes with Diversin (show ANKRD6 Antibodies) in the activation of JNK (show MAPK8 Antibodies)/AP-1 (show JUN Antibodies) signaling.
FRAT-2 enhances glycogen synthase kinase 3 beta (show GSK3b Antibodies)-mediated phosphorylation of a primed substrate to a greater extent than an unprimed substrate
It suggests that activation of GSK-3 (show GSK3b Antibodies) inhibits PP-2A through up-regulation of I(2)(PP-2A) with hnRNP (show HNRNPC Antibodies) A18-involved mechanism.
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.
GSK-3 binding protein FRAT2
, frequently rearranged in advanced T-cell lymphomas 2
, GSK-3-binding protein FRAT2