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FRAT2 antibody (AA 131-230) (Biotin)

FRAT2 Reactivity: Mouse WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1701037
  • Target See all FRAT2 Antibodies
    FRAT2 (Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
    Binding Specificity
    • 14
    • 9
    • 8
    • 7
    • 1
    AA 131-230
    Reactivity
    • 17
    • 14
    Mouse
    Host
    • 29
    • 1
    • 1
    Rabbit
    Clonality
    • 31
    Polyclonal
    Conjugate
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FRAT2 antibody is conjugated to Biotin
    Application
    • 30
    • 15
    • 14
    • 13
    • 13
    • 13
    • 7
    • 5
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat,Dog,Cow,Sheep
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FRAT2
    Isotype
    IgG
    Top Product
    Discover our top product FRAT2 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    FRAT2 (Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
    Alternative Name
    FRAT2 (FRAT2 Products)
    Synonyms
    FRAT2 antibody, FRAT2, WNT signaling pathway regulator antibody, frequently rearranged in advanced T cell lymphomas 2 antibody, frequently rearranged in advanced T-cell lymphomas 2 antibody, FRAT2 antibody, Frat2 antibody
    Background

    Synonyms: Frequently rearranged in advanced T-cell lymphomas 2 antibodyGSK-3 binding protein FRAT2, FRAT2_HUMAN.

    Background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

    Gene ID
    23401
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