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The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Additionally we are shipping FRAT2 Antibodies (50) and FRAT2 Kits (2) and many more products for this protein.
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Data show that MLL (show MLL Proteins) fusion oncogenes maintain leukemia-associated Rac (show AKT1 Proteins) GTPases activity by regulating Frat gene expression, specifically Frat2.
Data show that that Frat synergizes with Diversin in the activation of JNK (show MAPK8 Proteins)/AP-1 (show JUN Proteins) signaling.
FRAT-2 enhances glycogen synthase kinase 3 beta-mediated phosphorylation of a primed substrate to a greater extent than an unprimed substrate
It suggests that activation of GSK-3 inhibits PP-2A through up-regulation of I(2)(PP-2A) with hnRNP (show HNRNPC Proteins) A18-involved mechanism.
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.
GSK-3 binding protein FRAT2
, frequently rearranged in advanced T-cell lymphomas 2
, GSK-3-binding protein FRAT2