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Fyn-Related Kinase Proteins (FRK)

The protein encoded by FRK belongs to the TYR family of protein kinases. Additionally we are shipping FRK Antibodies (146) and FRK Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat FRK FRK 25468 P63142
FRK 2444 P42685
FRK 14302 Q922K9
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Top FRK Proteins at

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 5 μg Log in to see 2 to 3 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
Insect Cells Human GST tag   10 μg Log in to see 3 to 4 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 11 to 13 Days
HOST_Sf-9 cells Human Un-conjugated   5 μg Log in to see 3 to 4 Days

FRK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

More Proteins for Fyn-Related Kinase (FRK) Interaction Partners

Human Fyn-Related Kinase (FRK) interaction partners

  1. Loss of FRK protein may be implicated into the tumorigenesis and cell motility/invasiveness of human cervical cancer.

  2. antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn (show FYN Proteins)-related Src (show SRC Proteins) family tyrosine kinase (show TXK Proteins).

  3. our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 (show CCND1 Proteins) nucleus accumulation and pRb (show RB1 Proteins) phosphorylation in glioma cells.

  4. FRK over-expression promoted beta-catenin (show CTNNB1 Proteins) translocation to the plasma membrane, where it formed complex with N-cadherin (show CDH2 Proteins).

  5. exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 (show STAT3 Proteins) activation, and cell proliferation sensitive to Src (show SRC Proteins) inhibitors

  6. Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR (show EGFR Proteins) interaction.

  7. The expression levels of FRK were significantly correlated with invasiveness in both Hep3B and HepG2 tumor cell lines.

  8. these results clearly indicate that FRK may play a protective role against the progression of glioma by suppressing cell migration and invasion

  9. Genetic variation near FRK/COL10A1 (show COL10A1 Proteins) and VEGFA (show VEGFA Proteins) are associated with advanced age-related macular degeneration.

  10. Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs.

Mouse (Murine) Fyn-Related Kinase (FRK) interaction partners

  1. Characterization of mice deficient in the Src (show SRC Proteins) family nonreceptor tyrosine kinase (show TYRO3 Proteins) Frk/rak. Decreases in the circulating levels of T3 but not T4 are reminiscent of euthyroid sick syndrome, a stress-associated clinical condition

  2. The tyrosine kinases Brk/PTK6/Sik (show PTK6 Proteins), Srm (show SRM Proteins), Frk/Rak/Gtk/Iyk/Bsk (show EPHA5 Proteins), and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk (show PTK6 Proteins) family, is highly conserved and distinct.

  3. Experiments with Fyn (show FYN Proteins)-deficient mice indicate that Fyn (show FYN Proteins) genotype does not influence ethanol consumption, neither under basal conditions nor following a deprivation period or stress.

  4. These results show that FRK affects beta cell number during embryogenesis and early in life, but is probably redundant for beta cell number and function in adult animals under normal conditions.

FRK Protein Profile

Protein Summary

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.

Gene names and symbols associated with Fyn-Related Kinase Proteins (FRK)

  • potassium voltage-gated channel, shaker-related subfamily, member 2 (Kcna2)
  • Fyn-related kinase (FRK)
  • fyn-related kinase (FRK)
  • fyn-related kinase (frk)
  • fyn-related kinase (Frk)
  • BK2 protein
  • BSK protein
  • BSK/IYK protein
  • C85044 protein
  • FRK protein
  • GTK protein
  • NGK1 protein
  • PTK5 protein
  • RAK protein

Protein level used designations for Fyn-Related Kinase Proteins (FRK)

Potassium (K+) channel protein alpha 2, voltage dependent , RAK , RBK2 , RCK5 , potassium voltage gated channel shaker related subfamily member 2 , potassium voltage-gated channel subfamily A member 2 , voltage-gated potassium channel subunit Kv1.2 , hypothetical protein LOC583550 , fyn-related kinase , tyrosine-protein kinase FRK-like , PTK5 protein tyrosine kinase 5 , nuclear tyrosine protein kinase RAK , protein-tyrosine kinase 5 , tyrosine-protein kinase FRK , B-cell src-homology tyrosine kinase , beta-cell Src-homology tyrosine kinase , intestine tyrosine kinase , GASK , GTK , gastrointestinal-associated kinase , gastrointestinal-associated tyrosine kinase , src related tyrosine kinase

25468 Rattus norvegicus
583550 Strongylocentrotus purpuratus
481970 Canis lupus familiaris
462953 Pan troglodytes
716267 Macaca mulatta
100403046 Callithrix jacchus
100448548 Pongo abelii
100488362 Xenopus (Silurana) tropicalis
100540680 Meleagris gallopavo
100593495 Nomascus leucogenys
2444 Homo sapiens
421747 Gallus gallus
509227 Bos taurus
14302 Mus musculus
79209 Rattus norvegicus
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