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G Protein-Coupled Receptor Kinase 4 Proteins (GRK4)

GRK4 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Additionally we are shipping G Protein-Coupled Receptor Kinase 4 Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRK4 2868 P32298
GRK4 14772 O70291
GRK4 59077 P70507
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Top G Protein-Coupled Receptor Kinase 4 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,652.00
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GRK4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for G Protein-Coupled Receptor Kinase 4 (GRK4) Interaction Partners

Fruit Fly (Drosophila melanogaster) G Protein-Coupled Receptor Kinase 4 (GRK4) interaction partners

  1. The significance of these findings is that AMPK is important in the regulation of glucagon (show GCG Proteins) signaling, suggesting that the organization of metabolic networks is highly conserved and that AMPK plays a prominent role in these networks.

  2. Loss of AMPK activity exacerbates neuronal loss and associated phenotypes in parkin (show PARK2 Proteins) and LRRK transgenic flies.

  3. Data suggest that that an Sgt1 (show SUGT1 Proteins)/Hsp90 (show HSP90 Proteins)-LKB1 (show STK11 Proteins)-AMPK pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors.

  4. AMPK gamma and alpha mutants altered lipid metabolism and showed persistent starvation behaviors.

  5. AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut (show GUSB Proteins)

  6. These results raise the possibility that muscle is one of major tissues in which AMPK plays a critical role on longevity and stress resistance.

  7. activated by AMP (show AMPH Proteins) in cell-free assays and by stresses that deplete ATP; the phosphorylated DmAMPK alpha subunit (show POLG Proteins) was mainly detected in the nucleus

  8. results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures

  9. LKB1 (show STK11 Proteins) and AMPK have roles in cell polarity and division [review]

Human G Protein-Coupled Receptor Kinase 4 (GRK4) interaction partners

  1. the association between GRK4(142V) and a larger decrease in blood pressure with angiotensin receptor blockers in hypertensive patients.

  2. Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215-2.745, P=0.004) but not in East Asians and Africans. [meta-analysis]

  3. Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (show NMUR1 Proteins) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C (show CLEC2G Proteins)-tail responsible for this GRK function.

  4. hGRK4gamma(142V) phosphorylates histone deacetylase (show HDAC1 Proteins) type 1 and promotes its nuclear export to the cytoplasm, resulting in increased AT1R (show AGTR1 Proteins) expression and greater pressor response to angiotensin II.

  5. A high sodium intake markedly increased the obesity risk in variants of GRK4 A486V regardless of sex amongst Korean children.

  6. The C-terminal region of FMRP (show FMR1 Proteins) interacts with a domain of GRK4 mRNA that is folded in four stem loops.

  7. GRK4alpha is more similar to GRK2 (show ADRBK1 Proteins) than GRK6 (show GRK6 Proteins). A fully ordered kinase C-tail reveals interactions linking the C-tail with important determinants of kinase activity, including the alphaB helix, alphaD helix, and the P-loop

  8. GRK4 genetic polymorphism plays an important role in the regulation of hypertension.

  9. Mutations in GRK4 gene is associated with stress fracture.

  10. Buffalo colostrum beta-lactoglobulin inhibits VEGF (show VEGFA Proteins)-induced angiogenesis by interacting with G protein-coupled receptor (show ADRA1A Proteins) kinase

Mouse (Murine) G Protein-Coupled Receptor Kinase 4 (GRK4) interaction partners

  1. The role of GRK2 (show ADRBK1 Proteins) in chronic ET-1 (show EDN1 Proteins)-induced insulin (show INS Proteins) resistance was investigated.

  2. GRK2 (show ADRBK1 Proteins) inhibits WNT (show WNT2 Proteins) signaling in osteoblasts

G Protein-Coupled Receptor Kinase 4 (GRK4) Protein Profile

Protein Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.

Gene names and symbols associated with GRK4

  • SNF1A/AMP-activated protein kinase (SNF1A)
  • G protein-coupled receptor kinase 4 (GRK4)
  • G protein-coupled receptor kinase 4 (grk4-b)
  • G protein-coupled receptor kinase 4 (grk4)
  • G protein-coupled receptor kinase 4 (grk4-a)
  • G protein-coupled receptor kinase 4 (Grk4)
  • A830025H08Rik protein
  • ampk protein
  • ampkalpha protein
  • CG3051 protein
  • dAMPKa protein
  • dAMPKalpha protein
  • DmAMPK alpha protein
  • Dmel\\CG3051 protein
  • EG:132E8.2 protein
  • FBgn0023169 protein
  • Gprk-4 protein
  • Gprk2l protein
  • GPRK4 protein
  • gprk4-a protein
  • gprk4-b protein
  • GRK protein
  • grk4 protein
  • GRK4a protein
  • IT11 protein
  • snf1a protein
  • zgc:153020 protein

Protein level used designations for GRK4

5'monophosphate-activated kinase , AMP-activated kinase , AMP-activated protein kinase , AMP-dependent kinase , CG3051-PA , CG3051-PB , CG3051-PC , G protein-coupled receptor kinase 4 , SNF/AMP-activated protein S/T kinase gamma subunit , SNF1A-PA , SNF1A-PB , SNF1A-PC , adenosine monophosphate-activated protein kinase , GRK5 , ITI1 , G protein-coupled receptor kinase 2, groucho gene related , g protein-coupled receptor kinase GRK4

GENE ID SPECIES
43904 Drosophila melanogaster
461082 Pan troglodytes
474158 Xenopus laevis
448587 Xenopus (Silurana) tropicalis
100330963 Danio rerio
100540688 Meleagris gallopavo
560761 Danio rerio
446831 Xenopus laevis
422879 Gallus gallus
2868 Homo sapiens
479075 Canis lupus familiaris
512489 Bos taurus
14772 Mus musculus
59077 Rattus norvegicus
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