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anti-G Protein-Coupled Receptor Kinase 6 (GRK6) Antibodies

GRK6 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Additionally we are shipping G Protein-Coupled Receptor Kinase 6 Proteins (8) and G Protein-Coupled Receptor Kinase 6 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRK6 2870 P43250
GRK6 26385 O70293
GRK6 59076  
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Top anti-G Protein-Coupled Receptor Kinase 6 Antibodies at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of anti-GRK6 Pab in HeLa cell lysate (Lane 1) and mouse heart tissue lysate (Lane 2). GRK6 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GRK6 AntibodyTitration: 1.0 µg/mL  Positive Control: Fetal Bladder 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-GRK6 Pab (ABIN390989) in HeLa cell lysate (Lane 1) and mouse heart tissue lysate (Lane 2). GRK6 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. GRK6 Antibody (C-term) (ABIN390989)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from Jurkat/COLO205/HuvEc cells, using GRK6 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using GRK6 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, WB GRK6 monoclonal antibody (M10), clone 8D4 Western Blot analysis of GRK6 expression in Jurkat . Detection limit for recombinant GST tagged GRK6 is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IP, IHC, WB Immunohistochemical analysis of GRK6 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of GRK6 expression in Jurkat (A), BJAB (B), Ramos (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details

GRK6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-G Protein-Coupled Receptor Kinase 6 Antibodies

  1. Human Polyclonal GRK6 Primary Antibody for EIA, IHC (p) - ABIN359047 : Stoffel, Randall, Premont, Lefkowitz, Inglese: Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. in The Journal of biological chemistry 1994 (PubMed)
    Show all 3 references for ABIN359047

  2. Human Monoclonal GRK6 Primary Antibody for ELISA, WB - ABIN561115 : McCormick, Segarra, Gasperini, Gulino, Tosato: Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor. in PLoS ONE 2009 (PubMed)

More Antibodies against G Protein-Coupled Receptor Kinase 6 Interaction Partners

Human G Protein-Coupled Receptor Kinase 6 (GRK6) interaction partners

  1. The expression of GRK6 mRNA and protein was significantly lower in hypopharyngeal squamous cell carcinoma than in corresponding adjacent non-tumor tissues. This was associated with aberrant methylation of the gene.

  2. Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese

  3. these results indicate that GRK6 complexes with AGS3 (show GPSM1 Antibodies)-Galphai2 (show GNAI2 Antibodies) to regulate CXCR2 (show CXCR2 Antibodies)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.

  4. GRK6 plays a predominant role in phosphorylation of FFA receptor (FFA)4.

  5. results suggested that GRK6 overexpression plays an important role in hepatocellular carcinoma

  6. Downregulation of GRK6 expression enhances CXCR4 (show CXCR4 Antibodies) signaling and promoted medulloblastoma cell migration.

  7. A reduced cortical concentration of GRK6 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.

  8. inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.

  9. A number of double mutations of GRK6 kinase within helices 3, 9, and 10 reduced phosphorylation of the beta2 adrenergic receptor (show ADRB2 Antibodies) and rhodopsin (show RHO Antibodies) compared to wild-type GRK6 kinase.

  10. Recruitment of beta-Arrestin 2 (show ARRB2 Antibodies), but not beta-Arrestin 1 (show ARRB1 Antibodies), to the active WHIM (show CXCR4 Antibodies)-mutant receptor is delayed compared to the WT CXCR4 (show CXCR4 Antibodies) receptor and Grk6 fails to associate with the WHIM (show CXCR4 Antibodies)-mutant receptor.

Mouse (Murine) G Protein-Coupled Receptor Kinase 6 (GRK6) interaction partners

  1. GRK6 directly phosphorylates Nfkbia (show NFKBIA Antibodies) at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha (show TNF Antibodies)-induced NF-kappaappaB signaling.

  2. these results indicate that GRK6 complexes with AGS3 (show GPSM1 Antibodies)-Galphai2 (show GNAI2 Antibodies) to regulate CXCR2 (show CXCR2 Antibodies)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.

  3. data demonstrate that GRK6 plays a feedback regulatory role in CXCR2 (show CXCR2 Antibodies)-mediated tumor development, invasion and metastasis

  4. G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance.

  5. Chemokine receptor CXCR2 (show CXCR2 Antibodies) interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis.

  6. Results identify GRK5 (show GRK5 Antibodies)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP6 Antibodies) during Wnt (show WNT2 Antibodies) signaling.

  7. Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity.

  8. In the absence of GRK6, the G-CSF (show CSF3 Antibodies)-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF (show CSF3 Antibodies), significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice.

  9. The results suggest that mouse G-protein-coupled receptor (show GPR34 Antibodies) kinase isoform 6-C may be considered a basic, prototypic representative of the GRK4 (show GRK4 Antibodies)-like kinases.

  10. These results demonstrate previously unknown crucial regulatory mechanisms that alter ARR/GRK expression levels in macrophages that might modify many, if not all, GPCR-mediated innate immune responses.

G Protein-Coupled Receptor Kinase 6 (GRK6) Antigen Profile

Protein Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with GRK6

  • G protein-coupled receptor kinase 6 (GRK6) antibody
  • G protein-coupled receptor kinase 6 (grk6) antibody
  • G protein-coupled receptor kinase 6 (Grk6) antibody
  • Gprk6 antibody
  • GRK6 antibody
  • MGC83187 antibody

Protein level used designations for GRK6

G protein-coupled receptor kinase 6 , G protein-coupled receptor kinase 6-like , g protein-coupled receptor kinase GRK6 , G-protein coupled receptor kinase 6

GENE ID SPECIES
416361 Gallus gallus
447337 Xenopus laevis
700000 Macaca mulatta
100379796 Xenopus (Silurana) tropicalis
100403264 Callithrix jacchus
100433745 Pongo abelii
100550765 Meleagris gallopavo
2870 Homo sapiens
26385 Mus musculus
59076 Rattus norvegicus
100684653 Canis lupus familiaris
521413 Bos taurus
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