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GRK6 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Additionally we are shipping G Protein-Coupled Receptor Kinase 6 Proteins (8) and G Protein-Coupled Receptor Kinase 6 Kits (2) and many more products for this protein.
Showing 10 out of 73 products:
Human Polyclonal GRK6 Primary Antibody for EIA, IHC (p) - ABIN359047
Stoffel, Randall, Premont, Lefkowitz, Inglese: Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. in The Journal of biological chemistry 1994
Show all 3 references for ABIN359047
Human Monoclonal GRK6 Primary Antibody for ELISA, WB - ABIN561115
McCormick, Segarra, Gasperini, Gulino, Tosato: Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor. in PLoS ONE 2009
The expression of GRK6 mRNA and protein was significantly lower in hypopharyngeal squamous cell carcinoma than in corresponding adjacent non-tumor tissues. This was associated with aberrant methylation of the gene.
Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese
these results indicate that GRK6 complexes with AGS3 (show GPSM1 Antibodies)-Galphai2 (show GNAI2 Antibodies) to regulate CXCR2 (show CXCR2 Antibodies)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.
GRK6 plays a predominant role in phosphorylation of FFA receptor (FFA)4.
results suggested that GRK6 overexpression plays an important role in hepatocellular carcinoma
Downregulation of GRK6 expression enhances CXCR4 (show CXCR4 Antibodies) signaling and promoted medulloblastoma cell migration.
A reduced cortical concentration of GRK6 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.
inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.
A number of double mutations of GRK6 kinase within helices 3, 9, and 10 reduced phosphorylation of the beta2 adrenergic receptor (show ADRB2 Antibodies) and rhodopsin (show RHO Antibodies) compared to wild-type GRK6 kinase.
Recruitment of beta-Arrestin 2 (show ARRB2 Antibodies), but not beta-Arrestin 1 (show ARRB1 Antibodies), to the active WHIM (show CXCR4 Antibodies)-mutant receptor is delayed compared to the WT CXCR4 (show CXCR4 Antibodies) receptor and Grk6 fails to associate with the WHIM (show CXCR4 Antibodies)-mutant receptor.
GRK6 directly phosphorylates Nfkbia (show NFKBIA Antibodies) at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha (show TNF Antibodies)-induced NF-kappaappaB signaling.
data demonstrate that GRK6 plays a feedback regulatory role in CXCR2 (show CXCR2 Antibodies)-mediated tumor development, invasion and metastasis
G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance.
Chemokine receptor CXCR2 (show CXCR2 Antibodies) interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis.
Results identify GRK5 (show GRK5 Antibodies)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP6 Antibodies) during Wnt (show WNT2 Antibodies) signaling.
Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity.
In the absence of GRK6, the G-CSF (show CSF3 Antibodies)-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF (show CSF3 Antibodies), significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice.
The results suggest that mouse G-protein-coupled receptor (show GPR34 Antibodies) kinase isoform 6-C may be considered a basic, prototypic representative of the GRK4 (show GRK4 Antibodies)-like kinases.
These results demonstrate previously unknown crucial regulatory mechanisms that alter ARR/GRK expression levels in macrophages that might modify many, if not all, GPCR-mediated innate immune responses.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
G protein-coupled receptor kinase 6
, G protein-coupled receptor kinase 6-like
, g protein-coupled receptor kinase GRK6
, G-protein coupled receptor kinase 6