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Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Additionally we are shipping GPR124 Kits (1) and and many more products for this protein.
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Human Polyclonal GPR124 Primary Antibody for IHC, ELISA - ABIN1003260
Carson-Walter, Watkins, Nanda, Vogelstein, Kinzler, St Croix: Cell surface tumor endothelial markers are conserved in mice and humans. in Cancer research 2001
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The GPI (show ITGA2 Antibodies)-anchored MMP inhibitor Reck (show RECK Antibodies) and the adhesion GPCR (show GPRC6A Antibodies) Gpr124 are integral components of the Wnt7a (show WNT7A Antibodies)/Wnt7b (show WNT7B Antibodies)-specific signaling complex required for brain angiogenesis and dorsal root ganglia neurogenesis.
Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1 (show ELMO1 Antibodies)-Dock180 (show DOCK1 Antibodies) and intersectin 1 (show ITSN1 Antibodies)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 (show ELMO1 Antibodies) = ELMO domain-containing protein 1 (show ELMOD1 Antibodies); Dock180 (show DOCK1 Antibodies) = dedicator of cytokinesis protein 1 (show DOCK1 Antibodies) 180 kDa)
Observed an inverse correlation between the expression of miR (show MLXIP Antibodies)-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR (show MLXIP Antibodies)-138-5p on the sensitivity to gefitinib.
Thrombin (show F2 Antibodies)-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein (show CD28 Antibodies) disulfide-isomerase (show P4HB Antibodies).
TEM5 expression during capillary morphogenesis is induced by the small GTPase (show RACGAP1 Antibodies) Rac (show AKT1 Antibodies) and mediates contact inhibition of proliferation in endothelial cells.
Proteolytically processed soluble tumor endothelial marker TEM5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v (show ITGAV Antibodies))beta3 to glycosaminoglycans
experiments indicate that Reck (show RECK Antibodies) and Gpr124 are part of the cell surface protein (show CD28 Antibodies) complex that transduces Wnt7a (show WNT7A Antibodies)- and Wnt7b (show WNT7B Antibodies)-specific signals in mammalian CNS Epithelial Cells to promote angiogenesis and regulate the BBB (show ALMS1 Antibodies).
Gpr124 is an endothelial GPCR (show GPBAR1 Antibodies) specifically required for endothelial Wnt (show WNT2 Antibodies) signaling and BBB (show ALMS1 Antibodies) integrity under pathological conditions in adult mice.
Vital role for GPR124 is potentiation of WNT7 (show WNT7B Antibodies)-induced canonical beta-catenin (show CTNNB1 Antibodies) signaling with important implications for understanding and manipulating CNS-specific angiogenesis.
Gpr124 functions as coactivator of Wnt7a (show WNT7A Antibodies)- and Wnt7b (show WNT7B Antibodies)-stimulated canonical Wnt (show WNT2 Antibodies) signaling via Frizzled receptor and Lrp (show LRP1 Antibodies) coreceptor and that Gpr124-stimulated signaling functions in concert with Norrin (show NDP Antibodies)/Frizzled4 (show FZD4 Antibodies) signaling to control CNS vascular development
GPR124, an orphan G protein-coupled receptor (show GPRC5C Antibodies), is required for CNS-specific vascularization and establishment of the blood-brain barrier.
TGF-beta (show TGFB1 Antibodies) stimulates Gpr124 expression which is required for angiogenic sprouting into neural tissues.
study shows that complete null or endothelial-specific GPR124 deletion resulted in embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube; results demonstrate CNS-specific angiogenesis regulation by an endothelial receptor
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube.
G protein-coupled receptor 124
, probable G-protein coupled receptor 124-like
, G-protein coupled receptor 124
, tumor endothelial marker 5