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Orphan receptor.. Additionally we are shipping and many more products for this protein.
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Study designed and synthesized a series of 2-PCCA (show PCCA Antibodies) analogues bearing a variety of substituents at the phenyl ring of the aniline moiety to determine the structure-activity relationship (SAR (show SARDH Antibodies)) in this region; SAR (show SARDH Antibodies) studies suggested that there is a hydrophobic pocket in the GPR88 binding site interacting with the aniline region of 2-PCCA (show PCCA Antibodies)
Analysis of Gpr88-adenosine A2AR (show ADORA2A Antibodies)-Cre transgenic mice shows that GPR88 in adenosine A2AR (show ADORA2A Antibodies) medium spiny neurons regulates locomotor and anxiety behaviors.
GPR88 expression in the corpus striatum is necessary to efficiently integrate effort and choice behavior.
Results demonstrate that GPR88 is implicated in a large repertoire of behavioral responses that engage motor activity, spatial learning, and emotional processing, reveal functional antagonism between GPR88 and delta opioid receptor activities in vivo
This study demonistrated that lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders.
G protein-coupled receptor 88
, G protein coupled receptor 88
, G-protein coupled receptor 88
, probable G-protein coupled receptor 88
, striatum-specific G-protein coupled receptor