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anti-GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) Antibodies

GABPA encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Additionally we are shipping GA Binding Protein Transcription Factor, alpha Subunit 60kDa Proteins (5) and GA Binding Protein Transcription Factor, alpha Subunit 60kDa Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GABPA 363735  
GABPA 2551 Q06546
GABPA 14390 Q00422
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Top anti-GA Binding Protein Transcription Factor, alpha Subunit 60kDa Antibodies at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-GABPA Antibody Titration: 0.5-1.0ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB GABPA Antibody (Center) (ABIN657961) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the GABPA antibody detected the GABPA protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ICC, ELISA, WB Figure 1: Confocal immunofluorescence analysis of Hela cells using GABPA mouse mAb (green) . Red: Actin filaments have been labeled using DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. Figure 2: Western blot analysis using GABPA mouse mAb against Hela (1), A549 (2), MCF-7 (3), NIH/3T3 (4) and SMMC-7721 (5) cell lysate. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to GABPA on HeLa cell (antibody concentration 10 µg/mL). GABPA monoclonal antibody (M05), clone 2D6 Western Blot analysis of GABPA expression in Hela NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to GABPA on HeLa cell (antibody concentration 10 µg/mL). GABPA monoclonal antibody (M03), clone M1 Western Blot analysis of GABPA expression in HeLa NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Gabpa  Sample Tissue: Mouse Lung lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB   100 μL Log in to see 10 to 11 Days
$550.00
Details
Human Rabbit Un-conjugated ICC, IF, IP, WB ICC/IF Image GABPA antibody [N2C2], Internal detects GABPA protein at nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: GABPA protein stained by GABPA antibody [N2C2], Internal , diluted at 1:1000. Red: phalloidin, a cytoskeleton marker, diluted at 1:200. Blue: Hoechst 33342 staining. Scale bar = 10 μm. WB Image GABPA antibody detects GABPA protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with GABPA antibody , diluted at a dilution of 1:1000. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: Raji B: K562 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated EIA, IF, WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details

GABPA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GA Binding Protein Transcription Factor, alpha Subunit 60kDa Antibodies

  1. Human Monoclonal GABPA Primary Antibody for IF, WB - ABIN394147 : Levy, Forman: C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements. in IUBMB life 2010 (PubMed)
    Show all 5 references for ABIN394147

  2. Human Monoclonal GABPA Primary Antibody for IF, WB - ABIN394447 : Eynon, Alves, Sagiv, Yamin, Sagiv, Meckel: Interaction between SNPs in the NRF2 gene and elite endurance performance. in Physiological genomics 2010 (PubMed)
    Show all 5 references for ABIN394447

  3. Human Monoclonal GABPA Primary Antibody for ICC, ELISA - ABIN969163 : Batchelor, Piper, de la Brousse, McKnight, Wolberger: The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 3 references for ABIN969163

  4. Human Monoclonal GABPA Primary Antibody for IF, WB - ABIN2869322 : Sawada, Simizu, Suzuki, Sawa, Goto, Hasegawa, Imai, Watanabe, Handa: Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 references for ABIN2869322

  5. Chicken Polyclonal GABPA Primary Antibody for IHC, WB - ABIN2792606 : Xue, Bollenbacher, Rovella, Tripuraneni, Du, Liu, Williams, McCoy, Leonard: GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. in Nature immunology 2004 (PubMed)

  6. Human Polyclonal GABPA Primary Antibody for WB - ABIN657961 : Bruni, Polosa, Gadaleta, Cantatore, Roberti: Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against GA Binding Protein Transcription Factor, alpha Subunit 60kDa Interaction Partners

Human GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) interaction partners

  1. ELF1 (show EFNA2 Antibodies) binding occurs at both TERT (show TERT Antibodies) promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS (show ETS1 Antibodies) motifs in the TERT (show TERT Antibodies) promoter region.

  2. The results suggest that NRF-2alpha is a regulator of SIRT3 (show SIRT3 Antibodies) expression and may shed light on how SIRT3 (show SIRT3 Antibodies) is upregulated during nutrient stress.

  3. GABPalpha Binding to Overlapping ETS (show ETS1 Antibodies) and CRE DNA Motifs Is Enhanced by CREB1 (show CREB1 Antibodies)

  4. Expression of the ETS transcription factor (show FEV Antibodies) GABPalpha is positively correlated to the BCR (show BCR Antibodies)-ABL1/ABL1 (show ABL1 Antibodies) ratio in CML (show BCR Antibodies) patients and affects imatinib sensitivity in vitro.

  5. study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b (show ITGAM Antibodies) as a novel GABP target gene

  6. GABPA thus directly links TERT (show TERT Antibodies) promoter mutations to aberrant expression in multiple cancers.

  7. GABPA exhibits an increase in binding signal with higher numbers of ETS (show ETS1 Antibodies) motifs per promoter. Analysis of the distance between inverted pairs of ETS (show ETS1 Antibodies) motifs within promoters and binding by p53 (show TP53 Antibodies), ETS1 (show ETS1 Antibodies) and GABPA, shows a coordination of binding for the 3.

  8. results demonstrate the functional importance of the C/EBPalpha (show CEBPA Antibodies) C-terminus beyond the bZIP DNA-binding and dimerization region, which may mediate cooperative activation by C/EBPalpha (show CEBPA Antibodies) and GABP of myeloid-specific genes

  9. GABP alpha is required for YAP (show YAP1 Antibodies) expression in vitro and in vivo, and that YAP (show YAP1 Antibodies) is an important effector downstream of GABP for cell survival and cell-cycle progression.

  10. When NRF-2alpha and NRF-2beta (show GABPb Antibodies) form a complex, the nuclear import of NRF (show NKRF Antibodies)-2alphabeta becomes strictly dependent on the nuclear localization signal within NRF-2beta (show GABPb Antibodies).

Mouse (Murine) GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) interaction partners

  1. GABPalpha Binding to Overlapping ETS (show ETS1 Antibodies) and CRE DNA Motifs Is Enhanced by CREB1 (show CREB1 Antibodies)

  2. conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression

  3. Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL (show ABL1 Antibodies)-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.

  4. NRF-2 (show NFE2L2 Antibodies) and NRF-1 (show NRF1 Antibodies) operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.

  5. Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx (show ZFX Antibodies) and Etv6 (show ETV6 Antibodies) transcription factors and prosurvival Bcl-2 (show BCL2 Antibodies) family members including Bcl-2 (show BCL2 Antibodies), Bcl-X(L (show BCL2L1 Antibodies)), and Mcl-1 (show MCL1 Antibodies) as direct GABP target genes.

  6. Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.

  7. chemical shift and secondary structure of the PNT (show ETS2 Antibodies)/SAM (show TTN Antibodies) domains

  8. Erralpha (show ESRRA Antibodies) and GA-binding protein a (show GPR153 Antibodies) partner with PGC-1alpha (show PPARGC1A Antibodies) in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes

  9. Gabpa function is essential and is not compensated for by other ETS (show ETS1 Antibodies) transcription factors and is consistent with a specific requirement for Gabp expression for the maintenance of target genes involved in embryo essential mitochondrial cellular functions

  10. GABP is essential for the regulation of IL-7Ralpha (show IL7R Antibodies) expression in T cells.

GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) Antigen Profile

Protein Summary

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with GABPA

  • GA binding protein transcription factor, alpha subunit 60kDa (gabpa-A) antibody
  • GA binding protein transcription factor, alpha subunit 60kDa (GABPA) antibody
  • GA binding protein transcription factor, alpha subunit 60kDa (gabpa) antibody
  • GA binding protein transcription factor, alpha subunit 60kDa (LOC100222977) antibody
  • GA binding protein transcription factor, alpha subunit (Gabpa) antibody
  • GA repeat binding protein, alpha (Gabpa) antibody
  • GA-binding protein transcription factor, alpha subunit (gabpa) antibody
  • e4tf antibody
  • E4TF1-60 antibody
  • E4TF1A antibody
  • GABPA antibody
  • gabpa-A antibody
  • GABPalpha antibody
  • NFT2 antibody
  • Nrf-2alpha antibody
  • NRF2 antibody
  • NRF2A antibody
  • RCH04A07 antibody
  • wu:fc12d11 antibody
  • X-alpha1 antibody
  • XrpFI antibody

Protein level used designations for GABPA

GA binding protein transcription factor, alpha subunit 60kDa , transcription factor GABP alpha subunit , GA binding protein transcription factor, alpha subunit (60kD) , GA-binding protein alpha chain-like , GA repeat binding protein, alpha , GA-binding protein alpha chain , nuclear respiratory factor 2 alpha , GA binding protein transcription factor alpha subunit 60kDa , GABP subunit alpha , human nuclear respiratory factor-2 subunit alpha , nuclear respiratory factor 2 alpha subunit , nuclear respiratory factor 2 subunit alpha , transcription factor E4TF1-60 , GA repeat binding protein alpha , GA-binding protein alpha-subunit , E4tf1-60 transcription factor

GENE ID SPECIES
378601 Xenopus laevis
443478 Ovis aries
474079 Pan troglodytes
100012735 Monodelphis domestica
100053853 Equus caballus
100126064 Xenopus (Silurana) tropicalis
100222977 Taeniopygia guttata
100406317 Callithrix jacchus
100438238 Pongo abelii
100466575 Ailuropoda melanoleuca
100548020 Meleagris gallopavo
100558009 Anolis carolinensis
100585028 Nomascus leucogenys
363735 Rattus norvegicus
2551 Homo sapiens
446729 Xenopus laevis
418478 Gallus gallus
478394 Canis lupus familiaris
510204 Bos taurus
14390 Mus musculus
58110 Danio rerio
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