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Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. Additionally we are shipping GFRA2 Proteins (17) and GFRA2 Kits (1) and many more products for this protein.
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Human Polyclonal GFRA2 Primary Antibody for IHC (fro), WB - ABIN2473789
Kotzbauer, Lampe, Heuckeroth, Golden, Creedon, Johnson, Milbrandt: Neurturin, a relative of glial-cell-line-derived neurotrophic factor. in Nature 1997
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Human Polyclonal GFRA2 Primary Antibody for ICC, ELISA - ABIN1002346
Klein, Sherman, Ho, Stone, Bennett, Moffat, Vandlen, Simmons, Gu, Hongo, Devaux, Poulsen, Armanini, Nozaki, Asai, Goddard, Phillips, Henderson, Takahashi, Rosenthal: A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. in Nature 1997
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High GFRalpha2 expression level leads to PTEN inactivation via Mir-17-5p up-regulation, promoting pancreatic tumor cell growth and chemoresistance.
GFRA2 variants associated with diabetic neuropathic pain.
The study shows co-localization of RET (show RET Antibodies) with GFRA1 (show GFRA1 Antibodies) and GFRA2 in myenteric ganglia of the adult human colon.
Cyclic AMP (show APRT Antibodies) signalling through PKA but not Epac (show RAPGEF3 Antibodies) is essential for neurturin (show NRTN Antibodies)-induced biphasic ERK1/2 (show MAPK1/3 Antibodies) activation and neurite outgrowths through GFRalpha2 isoforms.
GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia.
This study found nominally-significant evidence for interactions between GFRA1 (show GFRA1 Antibodies), 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.
Both GFR (show RAPGEF5 Antibodies) alpha2a and GFR (show RAPGEF5 Antibodies) alpha2c, but not GFR (show RAPGEF5 Antibodies) alpha2b (show ADRA2B Antibodies), promote neurite outgrowth in transfected Neuro2A cells.
Ret (show RET Antibodies) and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later.
STAT3 (show STAT3 Antibodies) phosphorylation by neurturin (show NRTN Antibodies) was found to be mediated specifically by GFRalpha2c and RET9 (show RET Antibodies) isoforms.
Cholinergic innervation of gastric mucosa depends on neurturin (show NRTN Antibodies)-GFRalpha2 signalling but is dispensable for gastrin (show GAST Antibodies) secretion and for basal and maximal acid output
our data demonstrate that RET (show RET Antibodies)/GFRalpha signals are dispensable for thymic T cell development in vivo
Transduction-function role for GFR (show RAPGEF5 Antibodies) alpha2/neurturin (show NRTN Antibodies) signalling in a specific class of sensory neurons.
The cholinergic subpopulation of sympathetic neurons requires GFR alpha 2 signaling for soma size and for growth or maintenance of target innervation.
Demonstrate a role for GFRalpha2-expressing enteric neurons in the downstream signaling of the glucagon (show GCG Antibodies)-like peptides to inhibit GI motility, but not in intestinal growth.
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
, GDNF family receptor alpha-2
, GDNF family receptor alpha 2
, glial cell line derived neurotrophic factor family receptor alpha 2
, GFR alpha 2
, GDNF family receptor alpha-2-like
, GDNF receptor beta
, GFR-alpha 2
, PI-linked cell-surface accessory protein
, RET ligand 2
, TGF-beta-related neurotrophic factor receptor 2
, TRN receptor, GPI-anchored
, glial cell line derived neurotrophic factor receptor, beta
, neurturin receptor alpha
, GDNF receptor alpha-2
, tyrosine kinase receptor ligand 2
, GFR alpha-2