anti-GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Antibodies

GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Additionally we are shipping GLE1 RNA Export Mediator Homolog (Yeast) Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GLE1 2733 Q53GS7
GLE1 362098 Q4KLN4
GLE1 74412 Q8R322
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Top anti-GLE1 RNA Export Mediator Homolog (Yeast) Antibodies at antibodies-online.com

Showing 10 out of 45 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-GLE1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Immunohistochemistry-Paraffin: GLE1 Antibody [NBP1-32714] - Paraffin-embedded Cal27 xenograft, using antibody at 1:500 dilution. Immunocytochemistry/Immunofluorescence: GLE1 Antibody [NBP1-32714] - Paraformaldehyde-fixed HeLa, using GLE1 antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with an alpha Tubulin antibody (Red) at 1:2500. 100 μL Log in to see 7 to 9 Days
$447.56
Details
Horse Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded rat testis, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with GLE1 Polyclonal Antibody, Unconjugated  at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Log in to see 14 to 21 Days
$295.90
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: HeLa 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image GLE1 antibody detects GLE1 protein at cytoplasm and nucleus in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. GLE1 antibody , diluted at 1:500. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$451.00
Details

GLE1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,
,
,
Rat (Rattus)


Mouse (Murine)


More Antibodies against GLE1 RNA Export Mediator Homolog (Yeast) Interaction Partners

Human GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) interaction partners

  1. It was concluded that the amyotrophic lateral sclerosis-linked Gle1-c.1965-2A>C mutation generates a protein isoform capable of both Gle1A- and Gle1B-ascribed functions, and thereby uncoupled from normal mechanisms of Gle1 regulation.

  2. We also suggest that lethal congenital contracture syndrome 1 (LCCS1) and lethal arthrogryposis with anterior horn disease (LAAHD), the two AMC subtypes related to GLE1, do not have sufficient clinical or molecular differentiation to be considered allelic disorders. Rather, GLE1 mutations cause a variable spectrum of AMC severity including a non-lethal variant described herein

  3. Restoration of miR (show MLXIP Antibodies)-127-3p and miR (show MLXIP Antibodies)-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1 (show UBXN11 Antibodies), GLE1 and PDIA6 (show PDIA6 Antibodies).

  4. We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis.

  5. Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review]

  6. Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1.

  7. Dbp5 (show SON Antibodies), Gle1-IP6 (show GPRIN2 Antibodies) and Nup159: a working model for mRNP export.

  8. defective zebrafish GLE1 function in human LCCS1 results in both neurogenic and non-neurogenic defects linked to the apoptosis of proliferative organ precursors

  9. The unique carboxyl-terminal 43 amino acid region of the hGle1B isoform mediates binding to the C-terminal non-phenylalanine- glycine region of the nucleoporin hCG1/NPL1.

  10. Mutations in mRNA export mediator GLE1 result in fetal motoneuron disease.

GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Antigen Profile

Protein Summary

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GLE1

  • CG14749 gene product from transcript CG14749-RA (CG14749) antibody
  • nucleoporin GLE1 (CpipJ_CPIJ014147) antibody
  • nucleoporin GLE1 (SJAG_03847) antibody
  • GLE1 RNA export mediator (GLE1) antibody
  • GLE1 RNA export mediator (Gle1) antibody
  • GLE1 RNA export mediator (yeast) (Gle1) antibody
  • GLE1 RNA export mediator homolog (yeast) (GLE1) antibody
  • 4933405K21Rik antibody
  • AA553313 antibody
  • Dmel\\CG14749 antibody
  • GLE1 antibody
  • Gle1l antibody
  • hGLE1 antibody
  • LCCS antibody
  • LCCS1 antibody

Protein level used designations for GLE1

CG14749-PA , nucleoporin GLE1 , GLE1 RNA export mediator homolog , GLE1-like protein , GLE1-like, RNA export mediator , GLE1 RNA export mediator-like (yeast

GENE ID SPECIES
35849 Drosophila melanogaster
6047573 Culex quinquefasciatus
7050485 Schizosaccharomyces japonicus yFS275
417212 Gallus gallus
2733 Homo sapiens
362098 Rattus norvegicus
74412 Mus musculus
480704 Canis lupus familiaris
540982 Bos taurus
100172586 Pongo abelii
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