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GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Additionally we are shipping GLE1 RNA Export Mediator Homolog (Yeast) Proteins (7) and many more products for this protein.
Showing 10 out of 42 products:
Cow (Bovine) Polyclonal GLE1 Primary Antibody for WB - ABIN2785781
Nousiainen, Kestilä, Pakkasjärvi, Honkala, Kuure, Tallila, Vuopala, Ignatius, Herva, Peltonen: Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease. in Nature genetics 2008
Human Polyclonal GLE1 Primary Antibody for EIA, IHC (p) - ABIN499894
Murphy, Wente: An RNA-export mediator with an essential nuclear export signal. in Nature 1996
We also suggest that lethal congenital contracture syndrome 1 (LCCS1) and lethal arthrogryposis with anterior horn disease (LAAHD), the two AMC subtypes related to GLE1, do not have sufficient clinical or molecular differentiation to be considered allelic disorders. Rather, GLE1 mutations cause a variable spectrum of AMC severity including a non-lethal variant described herein
Restoration of miR (show MLXIP Antibodies)-127-3p and miR (show MLXIP Antibodies)-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1 (show UBXN11 Antibodies), GLE1 and PDIA6 (show PDIA6 Antibodies).
We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis.
Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review]
Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1.
Dbp5 (show SON Antibodies), Gle1-IP6 (show GPRIN2 Antibodies) and Nup159: a working model for mRNP export.
defective zebrafish GLE1 function in human LCCS1 results in both neurogenic and non-neurogenic defects linked to the apoptosis of proliferative organ precursors
The unique carboxyl-terminal 43 amino acid region of the hGle1B isoform mediates binding to the C-terminal non-phenylalanine- glycine region of the nucleoporin hCG1/NPL1.
Mutations in mRNA export mediator GLE1 result in fetal motoneuron disease.
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, nucleoporin GLE1
, GLE1 RNA export mediator homolog
, GLE1-like protein
, GLE1-like, RNA export mediator
, GLE1 RNA export mediator-like (yeast