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GRB2-Related Adaptor Protein Proteins (GRAP)

GRAP encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. Additionally we are shipping GRAP Antibodies (52) and GRAP Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRAP 10750 Q13588
GRAP 71520 Q9CX99
Rat GRAP GRAP 363616  
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Top GRAP Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,539.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GRAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for GRB2-Related Adaptor Protein (GRAP) Interaction Partners

Human GRB2-Related Adaptor Protein (GRAP) interaction partners

  1. Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from fibrotic kidneys from diabetic patients, and subsequently confirmed a (show TGFB1 Proteins)s a novel component of TGF-beta signaling in cultured human renal tubule cells.

  2. Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome.

  3. Our findings define a pathway involving CD28 (show CD28 Proteins) binding to Grb-2 (show GRB2 Proteins) and its co-operativity with Vav1 (show VAV1 Proteins) in the regulation of T-cell co-stimulation.

Mouse (Murine) GRB2-Related Adaptor Protein (GRAP) interaction partners

  1. Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from diabetic mice, indicating a potential novel role for GRAP in TGF-beta (show TGFB1 Proteins)-induced tubule injury in diabetic kidney disease.

  2. Data suggest that Grap, unlike Grb2 (show GRB2 Proteins), acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk (show EPHB2 Proteins) pathway.

  3. Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome.

  4. FcgammaRIIB docking site for the SH2 domain-containing adapters Grb2 (show GRB2 Proteins) and Grap

GRAP Protein Profile

Protein Summary

This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

Gene names and symbols associated with GRAP

  • GRB2-related adaptor protein (GRAP)
  • GRB2-related adaptor protein a (grapa)
  • zgc:109892 (zgc:109892)
  • GRB2-related adaptor protein (Grap)
  • 8430435N19Rik protein
  • BB233594 protein
  • grap protein
  • MGC109892 protein
  • si:dkeyp-9d4.1 protein
  • zgc:110202 protein

Protein level used designations for GRAP

GRB2-related adaptor protein , GRB2-related adapter protein , growth factor receptor-bound protein 2-related adaptor protein

GENE ID SPECIES
416523 Gallus gallus
489534 Canis lupus familiaris
553596 Danio rerio
555184 Danio rerio
10750 Homo sapiens
71520 Mus musculus
363616 Rattus norvegicus
534491 Bos taurus
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