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Galanin Receptor 2 Proteins (GALR2)

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. Additionally we are shipping Galanin Receptor 2 Antibodies (76) and Galanin Receptor 2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GALR2 8811 O43603
GALR2 14428 O88854
Rat GALR2 GALR2 29234 O08726
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Top Galanin Receptor 2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details

GALR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Galanin Receptor 2 (GALR2) Interaction Partners

Human Galanin Receptor 2 (GALR2) interaction partners

  1. GAL (show GAL Proteins) and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis

  2. The G protein-coupled receptor (show ADRA1A Proteins) GALR2 promotes angiogenesis in head and neck cancer

  3. In HEp (show EPHB6 Proteins)-2 cells, GALR2-mediated apoptosis was caspase (show CASP3 Proteins)-independent.

  4. Data from ligand-receptor interaction studies suggest that human spexin-1 and zebrafish spexin-2 activate galanin receptors GALR2/GALR3 (but not GALR1); thus spexins appear to be natural ligands for human/Xenopus/zebrafish GALR2/GALR3.

  5. Variants in genes for galanin (GAL (show GAL Proteins)) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.

  6. Activation of GalR2 leads to elevation of intracellular Ca(2 (show CA2 Proteins)+) due to Ca(2 (show CA2 Proteins)+) efflux from endoplasmic reticulum through IP3R (show ITPR1 Proteins) sequentially opening BK alpha channels.

  7. The expression of GALR2 mRNA is lost in head and neck squamous cell carcinoma as a consequence of DNA methylation.Silencing of the GALR2 gene by methylation may be a critical event in head and neck squamous cell carcinoma.

  8. galanin receptor 2 promotes cell proliferation and survival, and promotes tumor growth, consistent with an oncogenic role for GALR2 in squamous cell carcinoma of the head and neck

  9. Elevated expression of galanin (show GAL Proteins) receptors in childhood neuroblastic tumors

  10. study indicates that a high level of GalR2 galanin (show GAL Proteins) receptor expression is able to inhibit cell proliferation and induce apoptosis in neuroblastoma (show ARHGEF16 Proteins) cells

Mouse (Murine) Galanin Receptor 2 (GALR2) interaction partners

  1. In chronic restraint stress, the expression of GalR2 is increased in the nucleus accumbens following antidepressant administration.

  2. Three age groups of the Galr2 overexpressing mice demonstrated decreased levels of immobility in the forced swim test, indicative of antidepressive-like behavior and/or increased stress resistance.

  3. High level of endogenous galanin (show GAL Proteins) in injured primary afferents activates peripheral GalR2, which leads to an increase in C-fibre mechanical activation thresholds and a marked reduction in evoked and ongoing nociceptive responses.

  4. To gain insight into the possible physiological significance of GALR2, phenotypic analysis of mice deficient in GALR2 was determined.

  5. lack of GalR2 activation in galanin (show GAL Proteins) knockout and GalR2-MUT (show MUT Proteins) animals is responsible for the observed developmental deficits in the dorsal root ganglia

  6. the discovery of an anxiogenic phenotype specific to the elevated plus-maze highlights the potential therapeutic efficacy of targeting GalR2 receptors in treating anxiety disorders

  7. These findings imply that the rise in endogenous galanin (show GAL Proteins) observed either after brain injury or in various disease states is an adaptive response that reduces apoptosis by the activation of GalR2, and hence Akt (show AKT1 Proteins) and ERK (show EPHB2 Proteins).

  8. Galr2 receptors stimulate vagal afferent mechanosensitivity in the gastro-esophageal afferent preparation.

  9. The present findings are consistent with a predicted antidepressant-like effect of GalR2 signaling, suggesting that GalR2 might be a valid drug target for depressive disorders.

  10. The result indicate that galanin (show GAL Proteins) and its receptors (GalR1 and GalR2) might regulate neurite extension in differentiating neural stem cells and even participate in the development of the nervous system.

Galanin Receptor 2 (GALR2) Protein Profile

Protein Summary

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

Gene names and symbols associated with Galanin Receptor 2 Proteins (GALR2)

  • galanin receptor 2 (GALR2)
  • galanin receptor 2 (LOC100037698)
  • galactose operon repressor (galR2)
  • DNA-binding transcriptional regulator GalR (galR2)
  • galanin receptor 2 (Galr2)
  • GALNR2 protein
  • GALR2 protein
  • mGalR protein

Protein level used designations for Galanin Receptor 2 Proteins (GALR2)

galanin receptor 2 , galanin receptor type 2 , galanin receptor type 2-like , galactose operon repressor , DNA-binding transcriptional regulator GalR , GAL2-R , GALR-2

GENE ID SPECIES
100051251 Equus caballus
468332 Pan troglodytes
705684 Macaca mulatta
770030 Gallus gallus
100037698 Ovis aries
100432092 Pongo abelii
1063374 Lactobacillus plantarum WCFS1
2766943 Yersinia pestis biovar Microtus str. 91001
8187940 Lactobacillus plantarum JDM1
9399506 Leuconostoc gasicomitatum LMG 18811
9784786 Lactobacillus plantarum subsp. plantarum ST-III
100392678 Callithrix jacchus
8811 Homo sapiens
14428 Mus musculus
29234 Rattus norvegicus
483325 Canis lupus familiaris
618629 Bos taurus
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