Gasdermin D Proteins (GSDMD)

Gasdermin D is a member of the gasdermin family. Additionally we are shipping Gasdermin D Antibodies (33) and Gasdermin D Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GSDMD 79792 P57764
GSDMD 69146 Q9D8T2
Rat GSDMD GSDMD 315084  
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Top Gasdermin D Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

GSDMD Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Gasdermin D (GSDMD) Interaction Partners

Human Gasdermin D (GSDMD) interaction partners

  1. Remarkably, the Enterovirus 71 protease 3C directly targets GSDMD and induces its cleavage, which is dependent on the protease activity.

  2. The pyroptosis is redefined as gasdermin D-mediated programmed necrosis. Gasdermin D are associated with various genetic diseases, and their cellular function and mechanism of activation.

  3. Overall, these data demonstrate that GSDMD is the direct and final executor of pyroptotic cell death.

  4. Studies show that the membrane-pores composed of gasdermin D-N domains (GSDMD-N domain) are required for pyroptosis.

  5. Studies indicate that gasdermin D (GSDMD) is cleaved by the activated caspases-1/4/5/11 between its N-terminal and C-terminal domains.

  6. Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta (show IL1B Proteins) in both canonical and non-canonical inflammasome responses.

  7. GSDMD N-terminal cleavage product oligomerizes in membranes to form pores that are visible by electron microscopy

  8. caspase-1 and caspase-4/5/11 specifically cleaved the linker between the amino-terminal gasdermin-N and carboxy-terminal gasde (show DCLRE1C Proteins)rmin-C domains in GSDM (show CASP4 Proteins)D, which was re (show CASP1 Proteins)quired and sufficient for pyroptosis

  9. Study investigated the expression pattern of the GSDM (show GSDMA Proteins) family genes in the upper gastrointestinal epithelium and cancers.

Mouse (Murine) Gasdermin D (GSDMD) interaction partners

  1. Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta (show IL1B Proteins) in both canonical and non-canonical inflammasome responses.

  2. identification of gasdermin D (Gsdmd) by genome-wide clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 nuclease (show DCLRE1C Proteins) screens of caspase-11 (show CASP4 Proteins)- and caspase-1 (show CASP1 Proteins)-mediated pyroptosis in mouse bone marrow macrophages

  3. gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation

  4. This study clearly shows that Gsdmd is not essential for development of mouse intestinal tract or epithelial cell differentiation.

Gasdermin D (GSDMD) Protein Profile

Protein Summary

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with Gasdermin D Proteins (GSDMD)

  • gasdermin D (GSDMD)
  • gasdermin D (Gsdmd)
  • 1810036L03Rik protein
  • AW558049 protein
  • DF5L protein
  • Dfna5l protein
  • GSDMD protein
  • Gsdmdc1 protein
  • M2-4 protein

Protein level used designations for Gasdermin D Proteins (GSDMD)

gasdermin domain containing 1 , gasdermin-D , gasdermin D , gasdermin domain-containing protein 1

GENE ID SPECIES
513939 Bos taurus
609395 Canis lupus familiaris
697137 Macaca mulatta
739712 Pan troglodytes
100604427 Nomascus leucogenys
79792 Homo sapiens
69146 Mus musculus
315084 Rattus norvegicus
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