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The protein encoded by GKN1 is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. Additionally we are shipping Gastrokine 1 Antibodies (89) and Gastrokine 1 Proteins (14) and many more products for this protein.
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Human Gastrokine 1 ELISA Kit for Sandwich ELISA - ABIN415287
Yoon, Cho, Choi, Back, Park, Lee, Choi, Ashktorab, Smoot, Nam, Lee, Park: Gastrokine 1 regulates NF-?B signaling pathway and cytokine expression in gastric cancers. in Journal of cellular biochemistry 2013
Low GKN1 expression is associated with gastric cancer.
GKN1 may contribute to the maintenance of gastric epithelial homeostasis and inhibit gastric carcinogenesis by down-regulating the gastrin-cholecystokinin B receptor (show CCKBR ELISA Kits) signaling pathway.
Gastrokine 1 indirectly participates in actin stabilization since its overexpression in gastric cancer cells strongly increases the expression of tight and adherens junction proteins
AMP-18 appears to act through PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) pathways to increase p21 (show CDKN1A ELISA Kits) phosphorylation, thereby reducing its nuclear accumulation to overcome the antiproliferative effects of TNF-alpha (show TNF ELISA Kits).
Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population.
GKN1 inhibits metastasis in gastric cancer cells.
GKN1 may shorten telomeres by acting as a potential c-myc (show MYC ELISA Kits) inhibitor that eventually leads to senescence and apoptosis in gastric cancer cells
GKN1 expression in the gastric mucosa of gastric cancer patients is decreased; this is associated with progression and prognosis of gastric cancer.
Data show that recombinant gastrokine 1 (GKN1) interacts with amyloid-beta peptide (1-40) preventing its aggregation.
These results suggest that GKN1 might be a target to inhibit the effects from H.pylori CagA (show S100A8 ELISA Kits).
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.
, 18 kDa antrum mucosa protein
, protein CA11 homolog
, BRICHOS domain containing 1