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GGPS1 is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. Additionally we are shipping GGPS1 Proteins (22) and GGPS1 Kits (6) and many more products for this protein.
Showing 10 out of 120 products:
Human Polyclonal GGPS1 Primary Antibody for EIA, WB - ABIN952509
Miyagi, Matsumura, Sagami: Human geranylgeranyl diphosphate synthase is an octamer in solution. in Journal of biochemistry 2007
Show all 5 references for ABIN952509
Human Polyclonal GGPS1 Primary Antibody for EIA, IHC (p) - ABIN357715
Kainou, Kawamura, Tanaka, Matsuda, Kawamukai: Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human. in Biochimica et biophysica acta 1999
Show all 4 references for ABIN357715
Human Polyclonal GGPS1 Primary Antibody for EIA, IHC (p) - ABIN357716
Kuzuguchi, Morita, Sagami, Sagami, Ogura: Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. in The Journal of biological chemistry 1999
Show all 3 references for ABIN357716
Human Polyclonal GGPS1 Primary Antibody for IHC (p), WB - ABIN389056
Jiang, Backlund, Wassif, Yergey, Porter: Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. in Molecular & cellular proteomics : MCP 2010
Human Polyclonal GGPS1 Primary Antibody for IHC (p), WB - ABIN389055
Iguchi, Katsuno, Niwa, Yamada, Sone, Waza, Adachi, Tanaka, Nagata, Arimura, Watanabe, Kaibuchi, Sobue: TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. in The Journal of biological chemistry 2009
Cow (Bovine) Polyclonal GGPS1 Primary Antibody for WB - ABIN2783410
Raz, Nardi, Azam, Cortes, Daley: Farnesyl transferase inhibitor resistance probed by target mutagenesis. in Blood 2007
GGPS1 is a key gene in the chlorophyll biosynthetic pathway.
results may support a model in which accumulation of susceptibility variants (including some in relevant genes, notably GGPS1) may lead to a possible genetic component of predisposition to atypical femoral fractures.
GGPPS1 may play a critical role during the development of HCC (show FAM126A Antibodies) from cirrhosis and is of clinical significance for predicting biological character of HCC (show FAM126A Antibodies).
Egr-1 (show EGR1 Antibodies) most likely does not induce the constitutive activation of Erk1/2 (show MAPK1/3 Antibodies) through its target gene GGPS1.
the Egr-1 (show EGR1 Antibodies)/GGPPS/Erk1/2 (show MAPK1/3 Antibodies) pathway is responsible for insulin (show INS Antibodies) resistance during hyperinsulinism
these results reveal a new EGR-1 (show EGR1 Antibodies)/GGPPS/MAPK (show MAPK1 Antibodies) signaling pathway that controls cigarette smoke-induced pulmonary inflammation.
Study suggested that GGPS1 -8188A ins (show INS Antibodies)/del polymorphism may confer susceptibility to femoral neck BMD (show BEST1 Antibodies) response to bisphosphonate therapy in Korean women.
Farnesyltranstransferase mutations are associated with lonafarnib resistance
Evidence for a non-membrane bound isoform of geranylgeranyl diphosphate synthase 1 in rat.
Depletion of GGPP in mouse oocytes impaired the proliferation of granulosa cells, primary-secondary follicle transition and female fertility. GGPP depletion inhibited Rho GTPase (show RACGAP1 Antibodies) geranylgeranylation and its GTPase (show RACGAP1 Antibodies) activity.
our data suggest that GGPPS is essential for maintaining fetal lung branching morphogenesis, which is possibly through regulating K-Ras prenylation.
GGPPS-controlled protein geranylgeranylation, which regulates formation of the insulin (show INS Antibodies) granule docked pool, is critical for beta cell function and insulin (show INS Antibodies) release during the development of type 2 diabetes mellitus
findings imply that GGPPS deletion induces hepatocyte apoptosis, which makes the liver vulnerable to hepatotoxicity.
the impact of deleting one copy of FT or GGT (show GGT1 Antibodies) on the development of amyloid-beta (Abeta (show APP Antibodies))-associated neuropathology and learning/memory impairments in APPPS1 double transgenic mice.
The authors show that an early response transcription factor Egr-1 (show EGR1 Antibodies) could tilt the signalling balance by blocking PI3K/Akt (show AKT1 Antibodies) signalling through PTEN (show PTEN Antibodies) and augmenting Erk/MAPK (show MAPK1 Antibodies) signalling through GGPPS, resulting in insulin (show INS Antibodies) resistance in adipocytes.
GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved.
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
geranylgeranyl pyrophosphate synthase 1
, geranylgeranyl pyrophosphate synthetase
, geranyl pyrophosphate synthase
, geranylgeranyl pyrophosphate synthase,chloroplastic
, geranylgeranyl diphosphate synthase 1
, (2E,6E)-farnesyl diphosphate synthase
, GGPP synthase
, farnesyl diphosphate synthase
, geranylgeranyl pyrophosphate synthase
, GGPP synthetase