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Plays a role in the formation of the nodes of Ranvier along myelinated axons. Additionally we are shipping GLDN Proteins (11) and GLDN Kits (2) and many more products for this protein.
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data indicate that mutations of GLDN or CNTNAP1 (show CNTNAP1 Antibodies) (MIM (show MTSS1 Antibodies): 616286), encoding essential components of the nodes of Ranvier and paranodes, respectively, lead to inherited nodopathies, a distinct disease entity among peripheral neuropathies
gliomedin, NF186, and contactin are novel target antigens in Guillain-Barre syndrome
Fibronectin (show FN1 Antibodies) type III-like domains of neurofascin (show NFASC Antibodies)-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier
OLF domains from H. sapiens olfactomedin-1 (show OLFM1 Antibodies) and M. musculus gliomedin were biophysically, biochemically, and structurally characterized.
Perlecan (show HSPG2 Antibodies) binds the clustering molecule gliomedin and enhances clustering of node of Ranvier components.
Here, we show that initial clustering of Na(+) channels at heminodes requires glial NrCAM (show NRCAM Antibodies) and gliomedin, as well as their axonal receptor neurofascin (show NFASC Antibodies) 186 (NF186).
Plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier (By similarity).
, cancer related gene - liver 2
, cancer-related gene liver 2 protein
, olfactomedin-related protein