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anti-Glucagon Receptor (GCGR) Antibodies

The protein encoded by GCGR is a glucagon receptor that is important in controlling blood glucose levels. Additionally we are shipping Glucagon Receptor Proteins (5) and Glucagon Receptor Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GCGR 2642 P47871
GCGR 14527 Q61606
GCGR 24953 P30082
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Top anti-Glucagon Receptor Antibodies at antibodies-online.com

Showing 10 out of 92 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat heart labeled with Anti Glucagon Receptor Polyclonal Antibody, Unconjugated (ABIN751528) followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of Liver using anti- GCGR antibody ABIN122453 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE antibody diluted at 1:1000 WB Image Glucagon Receptor antibody detects Glucagon Receptor protein by western blot analysis. Whole cell extracts (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Glucagon Receptor antibody , at a dilution of 1:1000. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of Liver using anti- GCGR antibody ABIN122259 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p) Anti-Glucagon Receptor antibody  ABIN1048671 IHC staining of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Glucagon Receptor staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. AEC was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Glucagon Receptor expression in PC12 (A), Jurkat (B) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated WB Western blot analysis of GCGR Antibody (Center) (ABIN1881367) pre-incubated without(lane 1) and with(lane 2) blocking peptide in CEM cell line lysate. GCGR (arrow) was detected using the purified Pab. Western blot analysis of GCGR Antibody (Center) (ABIN1881367) pre-incubated without(lane 1) and with(lane 2) blocking peptide in CEM cell line lysate. GCGR (arrow) was detected using the purified Pab. 400 μL Log in to see 10 to 11 Days
$324.50
Details

GCGR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Glucagon Receptor Antibodies

  1. Human Polyclonal Glucagon Receptor Primary Antibody for IF (p), IHC (p) - ABIN751528 : Rafacho, Gonçalves-Neto, Santos-Silva, Alonso-Magdalena, Merino, Taboga, Carneiro, Boschero, Nadal, Quesada: Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats. in PLoS ONE 2014 (PubMed)

  2. Human Polyclonal Glucagon Receptor Primary Antibody for ELISA, WB - ABIN334409 : Sørensen, Winzell, Brand, Fosgerau, Gelling, Nishimura, Ahren: Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function. in Diabetes 2006 (PubMed)

More Antibodies against Glucagon Receptor Interaction Partners

Human Glucagon Receptor (GCGR) interaction partners

  1. 2.5 A crystal structure of human GCGR in complex with the antagonist MK-0893, which is found to bind to an allosteric site outside the seven transmembrane helical bundle in a position between TM6 and TM7 extending into the lipid bilayer

  2. Molecular dynamics and disulfide crosslinking studies suggest that apo (show C9orf3 Antibodies)-GCGR can adopt both an open and closed conformation associated with extensive contacts between the ECD (show SHFM1 Antibodies) and 7TM domain. Glucagon (show GCG Antibodies) binds to GCGR by a conformational selection mechanism.

  3. glucagon (show GCG Antibodies) cell adenomatosis with GCGR germline mutations seems to follow an autosomal-recessive trait.

  4. Using a real-time time-resolved FRET-based internalization assay, we show that GLP-1R (show GLP1R Antibodies), GIPR (show GIPR Antibodies), and GCGR internalize with differential properties

  5. crystal structure of the seven transmembrane helical domain of human GCGR at 3.4 A resolution, and a hybrid model of glucagon (show GCG Antibodies) bound to GCGR to understand the molecular recognition of the receptor for its native ligand

  6. Letter/Case Report: nonfunctional glucagon (show GCG Antibodies) cell adenomatosis with no detectable glucagon receptor mutations.

  7. GRA1 is a potent glucagon receptor antagonist with strong antihyperglycemic efficacy in preclinical models and prominent effects on hepatic gene-expression related to amino acid metabolism

  8. F22, V23, M27, and D15 (show MRPL16 Antibodies) of GCGR are the most important residues for glucagon (show GCG Antibodies) binding.

  9. in addition to activation of the classic cAMP/protein kinase A (PKA) pathway, activation of GCGR also induced beta-catenin (show CTNNB1 Antibodies) stabilization and activated beta-catenin (show CTNNB1 Antibodies)-mediated transcription

  10. analysis of glucagon receptor antagonists with reduced molecular weight and lipophilicity

Mouse (Murine) Glucagon Receptor (GCGR) interaction partners

  1. glucagon receptor antagonist improves glycemia in diet-induced obese angptl4 (show ANGPTL4 Antibodies) knockout mice without increasing glucagon (show GCG Antibodies) levels or alpha-cell proliferation, underscoring the importance of this protein.

  2. Data indicate that the exocrine pancreas in the glucagon receptor Gcgr-/- mice exhibited larger nuclear size than in WT or heterozygous controls, most obviously at old ages.

  3. Simultaneous and sufficient activation of GLP1R (show GLP1R Antibodies) is required to reduce GCCR (show NR3C1 Antibodies) mediated blood glucose elevation following administration of a GLP1R (show GLP1R Antibodies)/GCGR co-agonist.

  4. Knockdown of liver glucagon receptor in mice reduces blood glucose and increases blood LDL levels.

  5. Gcgr(-/-) mice became lethargic (show CACNB4 Antibodies) & cachexic & died early. Autopsy revealed numerous PNETs up to 15 mm in diameter in most well-preserved Gcgr(-/-) pancreata.

  6. Data suggest that GcgR activation raises hepatic expression of fibroblast growth factor 21 (FGF21 (show FGF21 Antibodies)) and increases circulating levels of FGF21 (show FGF21 Antibodies); GcgR activation induces body weight loss and stimulates lipid metabolism.

  7. These results suggest that a circulating factor generated after disruption of hepatic Gcgr signaling can increase alpha-cell proliferation independent of direct pancreatic input.

  8. GRA1 is a potent glucagon receptor antagonist with strong antihyperglycemic efficacy in preclinical models and prominent effects on hepatic gene-expression related to amino acid metabolism

  9. Data suggest that both Gcgr activity and glucagon-like peptide 1 (show GCG Antibodies)/Glp1r (show GLP1R Antibodies) signal transduction in central nervous system are involved in control of interscapular brown adipose tissue thermogenesis.

  10. A novel transgenic mouse was generated which had muscle specific (show EIF3K Antibodies) expression of glucagon receptor. The transgenic mice maintained an appropriate ratio of glucagon (show GCG Antibodies) to insulin (show INS Antibodies), which appears important in maintaining glucose homeostasis.

Glucagon Receptor (GCGR) Antigen Profile

Protein Summary

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).

Gene names and symbols associated with GCGR

  • glucagon receptor (GCGR) antibody
  • gastric inhibitory polypeptide receptor (GIPR) antibody
  • glucagon receptor (Gcgr) antibody
  • GCGR antibody
  • GGR antibody
  • GR antibody

Protein level used designations for GCGR

glucagon receptor , glucagon receptor-like , GL-R , glucagon receptor perhaps same as Niddm3

GENE ID SPECIES
714542 Macaca mulatta
468357 Pan troglodytes
100390029 Callithrix jacchus
100448994 Pongo abelii
100597318 Nomascus leucogenys
425670 Gallus gallus
2642 Homo sapiens
14527 Mus musculus
24953 Rattus norvegicus
483368 Canis lupus familiaris
515433 Bos taurus
100733098 Cavia porcellus
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