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anti-Glucosidase, Beta, Acid (GBA) Antibodies

GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Additionally we are shipping GBA Proteins (22) and GBA Kits (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GBA 684536  
GBA 2629 P04062
GBA 14466 P17439
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Top anti-GBA Antibodies at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to GBA on HeLa cell (antibody concentration 10 µg/mL). Western Blot analysis of GBA expression in transfected 293T cell line by GBA monoclonal antibody (M01), clone 2E2. Lane 1: GBA transfected lysate(60 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to GBA on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to GBA on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed HeLa, using GBA, antibody at 1:100 dilution. WB Image Sample(30 μg of whole cell lysate) A:Hep G2, 7.5% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB 0.1 mL Log in to see 5 to 7 Days
$452.81
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human hepatoma, using GBA, antibody at 1:500 dilution. WB Image GBA antibody detects GBA protein by Western blot analysis. A. 30 µg HepG2 whole cell lysate/extract 10 % SDS-PAGE GBA antibody , dilution: 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$385.00
Details

GBA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus) ,


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Human , ,
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Mouse (Murine) ,


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Top referenced anti-GBA Antibodies

  1. Human Monoclonal GBA Primary Antibody for IF, IHC (p) - ABIN561009 : Campeau, Rafei, Boivin, Sun, Grabowski, Galipeau: Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome. in Blood 2009 (PubMed)
    Show all 5 references for ABIN561009

  2. Human Monoclonal GBA Primary Antibody for IF, WB - ABIN394481 : Dos Santos, Pestana, Diniz, Campos, Abdalla-Carvalho, de Rosso, Pereira, Nicaretta, de Carvalho, Dos Santos, Santos-Rebouças, Pimentel: Mutational analysis of GIGYF2, ATP13A2 and GBA genes in Brazilian patients with early-onset Parkinson's disease. in Neuroscience letters 2010 (PubMed)
    Show all 5 references for ABIN394481

  3. Human Polyclonal GBA Primary Antibody for ICC, IF - ABIN442242 : Zancan, Bellesso, Costa, Salvalaio, Stroppiano, Hammond, Argenton, Filocamo, Moro: Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling. in Human molecular genetics 2015 (PubMed)

More Antibodies against GBA Interaction Partners

Arabidopsis thaliana Glucosidase, Beta, Acid (GBA) interaction partners

  1. Results describe the characterization of a beta-glucosidase homolog from Arabidopsis thaliana.

Human Glucosidase, Beta, Acid (GBA) interaction partners

  1. findings showed that Gaucher disease (GD)-associated GBA mutations were not only associated with the development of Parkinson's disease (PD) but also had a great impact on developing dementia and psychosis in the clinical course of PD

  2. This study discovery that E326K of GBA negatively impacts cognitive performance approximately doubles the proportion of PD patients

  3. This study showed the presence of six LRRK2 (show LRRK2 Antibodies) p.G2019S and nine GBA p.N370S mutation carriers in Parkinson disease.

  4. GBA1 mutations interfere with TFEB (show TFEB Antibodies)-mediated lysosomal biogenesis, and that the action of GBA in maintaining a functioning pool of lysosomes is exerted in part through TFEB (show TFEB Antibodies).

  5. results suggests that the GBA gene may be a susceptibility gene for Parkinson's disease in the Chinese population (meta-analysis)

  6. the most frequent L444P mutation of the GBA gene may be associated with the development of early-onset Parkinson disease in the Hungarian population.

  7. This study did not demonstrate glucocerebrosidase substrate accumulation in Parkinson's disease brains with heterozygote GBA1 mutations in areas of the brain with low alpha-synuclein (show SNCA Antibodies) pathology.

  8. The most highly correlated pair of residue variations is alpha-synuclein (show SNCA Antibodies) A53T and glucocerebrosidase G115E. Intriguingly, the A53T mutation is a Parkinson's disease risk factor in humans, suggesting the pathology associated with this mutation

  9. The present study used a meta-analysis approach, pooling the appropriate data from published studies to investigate the association of GBA mutations and Parkinson's disease in a Chinese population.

  10. A pattern of combined segregation with GBA and LRRK2 (show LRRK2 Antibodies) was found in a Brazilian family with Parkinson's disease.

Mouse (Murine) Glucosidase, Beta, Acid (GBA) interaction partners

  1. In LIMP-2 (show SCARB2 Antibodies)-deficient brains a significant reduction in GC activity led to lipid storage, disturbed autophagic/lysosomal function, and alpha-synuclein (show SNCA Antibodies) accumulation.

  2. heterozygosity for a Gaucher disease-associated mutation in glucocerebrosidase interferes with alpha-synuclein (show SNCA Antibodies) degradation and contributes to its accumulation

  3. Data indicate that ABC transporter A family member 12 knockout (Abca12 (show ABCA12 Antibodies)(-/-)) epidermis had 5-fold more beta-glucocerebrosidase (GCase) protein, and a 5-fold increase in GCase activity.

  4. These results demonstrate, for the first time, a novel function of GBA1 as a beta (show SUCLA2 Antibodies)-ChlGlc-synthesizing enzyme.

  5. Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease.

  6. GBA1 and GBA2 (show GBA2 Antibodies) activities had characteristic differences between the studied fibroblast, liver and brain samples.

  7. results not only point to a fundamental role for GBA in immune regulation but also suggest that GBA mutations in GD may cause widespread immune dysregulation through the accumulation of substrates

  8. This study suggested that several leads connecting GBA1 mutations with alpha-synuclein (show SNCA Antibodies) misprocessing have emerged as potential targets for the treatment of GBA1-related synucleinopathies.

  9. IFG (show IFNG Antibodies) stabilizes GCase in tissues and serum and can reduce visceral substrates in vivo.

  10. Mutations in GBA1 can cause Parkinson disease-like alpha-synuclein (show SNCA Antibodies) pathology; rescuing brain glucocerebrosidase activity might represent a therapeutic strategy for GBA1-associated synucleinopathies.

Pig (Porcine) Glucosidase, Beta, Acid (GBA) interaction partners

  1. genetic analysis and mapping of the porcine glucocerebrosidase (GBA) gene

GBA Antigen Profile

Protein Summary

This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with GBA

  • glucosidase, beta, acid (Gba) antibody
  • glucosidase, beta, acid (GBA) antibody
  • beta glucosidase 25 (BGLU25) antibody
  • beta-glucosidase (PSPTO_3318) antibody
  • beta-glucosidase (bglX) antibody
  • beta-glucosidase (bglH-2) antibody
  • beta-glucosidase (bglX-1) antibody
  • beta-glucosidase (bglX-2) antibody
  • beta-glucosidase (bglA.2) antibody
  • bglX-2 (bglX-2) antibody
  • Beta-glucosidase (bglA4) antibody
  • BETA-GLUCOSIDASE antibody
  • betaGC antibody
  • beta glucosidase 25 antibody
  • GBA1 antibody
  • GC antibody
  • GCase antibody
  • GCB antibody
  • GLUC antibody
  • PSPTO3318 antibody
  • PSPTO4290 antibody
  • T12J13.8 antibody
  • T12J13_8 antibody

Protein level used designations for GBA

glucocerebrosidase , glucosidase, beta, acid , glucosylceramidase-like , beta-glucosidase , Beta-glucosidase , D-glucosyl-N-acylsphingosine glucohydrolase , acid beta-glucosidase , alglucerase , beta-glucocerebrosidase , glucosylceramidase , imiglucerase , lysosomal glucocerebrosidase , acid beta glucosidase , glucosidase, beta; acid (includes glucosylceramidase) , glucosidase, beta; acid

GENE ID SPECIES
684536 Rattus norvegicus
100399524 Callithrix jacchus
821201 Arabidopsis thaliana
1184976 Pseudomonas syringae pv. tomato str. DC3000
1185971 Pseudomonas syringae pv. tomato str. DC3000
2797087 Listeria monocytogenes serotype 4b str. F2365
2799486 Listeria monocytogenes serotype 4b str. F2365
2799824 Listeria monocytogenes serotype 4b str. F2365
3573796 Streptococcus pyogenes MGAS6180
4464997 Listeria welshimeri serovar 6b str. SLCC5334
5812753 Sorangium cellulosum So ce56
8955533 Sphingobium japonicum UT26S
2629 Homo sapiens
14466 Mus musculus
537087 Bos taurus
449572 Sus scrofa
100174563 Pongo abelii
449571 Pan troglodytes
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