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Glutamate Dehydrogenase 2 Proteins (GLUD2)

The protein encoded by GLUD2 is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. Additionally we are shipping Glutamate Dehydrogenase 2 Antibodies (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GLUD2 2747 P49448
Mouse GLUD2 GLUD2 104277  
Rat GLUD2 GLUD2 79220 Q63226
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Top Glutamate Dehydrogenase 2 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

GLUD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for Glutamate Dehydrogenase 2 (GLUD2) Interaction Partners

Human Glutamate Dehydrogenase 2 (GLUD2) interaction partners

  1. Study of the expression of the GDH1 (show GLUD1 Proteins)/2 in human steroidogenic organs revealed that, while GDH2 was expressed specifically in steroid-synthesizing cells, GDH1 (show GLUD1 Proteins) was expressed both in the cells that produce steroids and in those that lack endocrine function.

  2. IDH1 (show IDH1 Proteins)(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate (show GRIN1 Proteins) turnover in human forebrain.

  3. hGDH2 can operate efficiently in the relatively acidic environment that prevails in astrocytes following glutamate (show GRIN1 Proteins) uptake [review]

  4. [review] Whereas GDH2 in most mammals is encoded by a single functional GLUD1 gene expressed widely, humans have acquired through retroposition an X-linked GLUD2 gene that encodes a highly homologous isoenzyme GDH2 expressed in testis and brain.

  5. Human GDH1 (show GLUD1 Proteins) appears to act like bovine GDH1 (show GLUD1 Proteins), but human GDH2 does not show the same enhancement of branched chain alpha-keto acid dehydrogenase complex enzyme activities.

  6. GLUD2 glutamate (show GRIN1 Proteins) dehydrogenase is expressed in neural and testicular supporting cells

  7. identify the structural basis for allosteric differences of GlUD1 (show GLUD1 Proteins) and GLUD2

  8. These results suggest that the Ser443 residue plays an important role in the different thermal stability of human glutamate (show GRIN1 Proteins) dehydrogenase isozymes (hGDH1 and hGDH2).

  9. GLUD2 originated by retroposition from GLUD1 (show GLUD1 Proteins) in the hominoid ancestor less than 23 million years ago.

  10. results suggest that cysteine 323 plays an important role in catalysis by human GDH (show GLUD1 Proteins) isozymes; C323 is not directly involved in allosteric regulation.

Arabidopsis thaliana Glutamate Dehydrogenase 2 (GLUD2) interaction partners

  1. In leaves and stems of arabidopsis and tobacco, both the alpha- and beta-subunits of Glutamate (show GRIN2A Proteins) dehydrogenase are targeted to the mitochondria of the companion cells.

  2. Protein phosphorylation by serine/threonine protein kinases is the essential step required for signal transduction into nucleus resulting in the induction of glutamate dehydrogenase 2 expression.

Mouse (Murine) Glutamate Dehydrogenase 2 (GLUD2) interaction partners

  1. GluD2 signaling induces parallel fiber protrusions that form circular structures and encapsulated Purkinje cell spines.

  2. These findings indicate how GluD2 is activated and regulates functions at parallel fiber-Purkinje cell synapses--{REVIEW}

  3. the flap (show ALOX5AP Proteins) loop (Arg321-Trp339) in the NTD of GluD2 (GluD2-NTD) was identified as a crucial region for the binding to Cbln1 (show CBLN1 Proteins) and the induction of presynaptic differentiation.

  4. The results of this study suggest that GluD2 differently regulates parallel fiber synaptogenesis and cerebellar long-term depression through the extracellular N-terminal domain and the cytoplasmic C-terminal end, respectively.

Glutamate Dehydrogenase 2 (GLUD2) Protein Profile

Protein Summary

The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.

Gene names and symbols associated with GLUD2

  • glutamate dehydrogenase 2 (gdhA_2)
  • glutamate dehydrogenase 2 (GLUD2)
  • glutamate dehydrogenase 2 (GDH2)
  • glutamate dehydrogenase, pseudogene (Glud-ps)
  • glutamate receptor, ionotropic, delta 2 (Grid2)
  • EG545999 protein
  • GDH2 protein
  • Glud-2 protein
  • GluD2 protein
  • GLUDP1 protein
  • glutamate dehydrogenase 2 protein
  • Gm5902 protein
  • T2I1.150 protein
  • T2I1_150 protein

Protein level used designations for GLUD2

glutamate dehydrogenase 2 , GDH 2 , glutamate dehydrogenase 2, mitochondrial , glutamate dehydrogenase pseudogene 1 , gluR delta-2 subunit , glutamate receptor delta-2 subunit , glutamate receptor ionotropic, delta-2

3702749 Natronomonas pharaonis DSM 2160
2747 Homo sapiens
830635 Arabidopsis thaliana
104277 Mus musculus
79220 Rattus norvegicus
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