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Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B Proteins (GRIN2B)

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. Additionally we are shipping GRIN2B Antibodies (360) and GRIN2B Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRIN2B 2904 Q13224
Rat GRIN2B GRIN2B 24410 Q00960
GRIN2B 14812 Q01097
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Top GRIN2B Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

GRIN2B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) Interaction Partners

Human Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) interaction partners

  1. GRIN2B polymorphisms do not influence Parkinson disease age of onset in the US Caucasian population.

  2. GluN2B appears to exhibit allosteric regulation/inhibition by two distinct classes of antagonists; data from in silico docking suggest that GluN2B-selective antagonists broadly divide into two distinct classes according to binding pose.

  3. Knockdown of PKD1 (show PKD1 Proteins) did not affect NMDAR (show GRIN1 Proteins) internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR (show GRIN1 Proteins)-mediated synaptic functions.

  4. GRIN2B encodes the NR2 subunit of NMDA receptors, which are a class of ionotropic glutamate (show GRIN1 Proteins) receptors involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission.

  5. ligand binding to cell surface GD2 induces rapid and transient activation of Src (show SRC Proteins)-family kinases, followed by Src (show SRC Proteins)-dependent phosphorylation of NMDA-receptor NR2B subunits selectively.

  6. Study provides evidence of an association between GRIN2B polymorphisms and Schizophrenia susceptibility and symptoms in the Han Chinese population.

  7. GFAP peaks early during haemorrhagic brain lesions (at significantly higher levels), and late in ischaemic events, whereas antibodies against NR2 RNMDA have significantly higher levels during ischemic stroke at all time-points.

  8. Polymorphisms in DRD1 (show DRD1 Proteins), DRD2 (show DRD2 Proteins) and GRIN2B confer increased risk of impulse control problems among PD patients.

  9. BDNF (show BDNF Proteins), APOE (show APOE Proteins), and HSP70-1 (show HSPA1A Proteins) genes, but not GRIN2B, might be associated with a risk of POAG occurrence in the Polish population

  10. This study provides further evidence in support of GRIN2B contributing toward Developmental Dyslexia and deficits in Developmental Dyslexia

Mouse (Murine) Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) interaction partners

  1. The results suggest that NR2B vulnerability represents a target for environmental toxicants in the brain.

  2. Results show that monomeric Abeta1-42 application induces an increase of the Ca2 (show CA2 Proteins)+-response and of the membrane expression of the extrasynaptic subunit of the NMDA receptor GluN2B in PC12 cells, while the opposite effects were observed in cultured neurons

  3. Results demonstrate that up-regulation of NR2B expression facilitates acquisition of auditory cued fear memory and enhances long-term potentiation at thalamus-lateral amygdala synapses

  4. Results suggest that EGFR (show EGFR Proteins) signaling upregulates NMDA receptors through modification of the GluN2B subunit, and is required for high-frequency stimulation-induced long-term potentiation in the hippocampus

  5. Loss of GluN2B in principal neurons of the forebrain results in reduced punished food reward-seeking.

  6. The sigma-1R deficiency through suppressing NR2B function and DAT (show SLC6A3 Proteins) expression can reduce MPTP (show PTPN2 Proteins)-induced death of dopaminergic neurons and parkinsonism.

  7. Study demonstrated that the GluN2B carboxy-terminal domain is necessary for enhanced social recognition memory in GluN2B transgenic overexpression mice

  8. Homer1a (show HOMER1 Proteins) may be a key neuroprotective endogenous molecule that protects against NMDA-induced neuronal injury by disassembling NR2B-PSD95 (show DLG4 Proteins)-nNOS (show NOS1 Proteins) complexes and reducing the membrane distribution of NR2B.

  9. Findings reveal an intimate reciprocal relationship between ErbB4 (show ERBB4 Proteins) and GluN2b NMDA receptors via NRG2 (show NRG2 Proteins)/ErbB4 (show ERBB4 Proteins) signaling.

  10. Visual plasticity in adult mice was dramatically enhanced following magnesium treatment, which was concurrent with an increase in the expression of NR2 subunits of N-methyl-D-aspartate receptors.

GRIN2B Protein Profile

Protein Summary

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.

Gene names and symbols associated with GRIN2B

  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B (Grin2b)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B (grin2b)
  • glutamate receptor, ionotropic, NMDA2B (epsilon 2) (Grin2b)
  • AW490526 protein
  • GluN2B protein
  • hNR3 protein
  • MRD6 protein
  • Nmdar2b protein
  • nr2b protein

Protein level used designations for GRIN2B

NMDA type glutamate receptor , N-methyl D-aspartate receptor subtype 2B , N-methyl-D-aspartate receptor subunit 2B , NMDAR2B , NR2B , glutamate [NMDA] receptor subunit epsilon-2 , glutamate receptor ionotropic, NMDA 2B , N-methyl-D-aspartate receptor subunit 3 , NR3 , glutamate receptor subunit epsilon-2 , glutamate receptor, ionotropic, NMDA2B , N-methyl-D-aspartate receptor subunit NR2B , GluRepsilon2 , N-methyl D-aspartate receptor 2B

GENE ID SPECIES
751956 Taeniopygia guttata
494009 Canis lupus familiaris
2904 Homo sapiens
24410 Rattus norvegicus
100127347 Xenopus laevis
14812 Mus musculus
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