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GRID1 encodes a subunit of glutamate receptor channels. Additionally we are shipping GRID1 Antibodies (66) and GRID1 Kits (12) and many more products for this protein.
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GRID1 expression is downregulated in both MECP2 (show MECP2 Proteins)- and CDKL5 (show CDKL5 Proteins)-mutated iPS (show SLC27A4 Proteins) cells and upregulated in neuronal precursors and mature neurons.
GRID1 genotype is related to gray matter variation in prefrontal and anterior thalamic brain areas in healthy subjects, but not in schizophrenia patients, indicating a potential role in thalamo-cortical functioning.
results strongly support previously reported association studies, implicating GRID1 in the etiology of schizophrenia
The results of this study suggested that genetic variants in the GRID1 transcriptional regulatory region may play a role in the etiology of schizophrenia.
GluD1 (show GLUD1 Proteins) interacts with mGlu5 (show GRM5 Proteins), and loss of GluD1 (show GLUD1 Proteins) impairs normal mGlu5 (show GRM5 Proteins) signaling potentially by dysregulating coupling to its effector.
Deletion of GluD1 (show GLUD1 Proteins) leads to aberrant circuitry in prefrontal cortex and amygdala. Furthermore, these findings are in agreement with the human genetic studies suggesting a strong association of GRID1 gene with several neuropsychiatric disorders.
GluRdelta1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with pre-synaptic neurexins containing splice segment 4 through Cbln subtypes.
The residues in the highly conserved SYTANLAAF region form the activation gate for GluRdelta1, since mutations in a set of closely arranged residues are found to generate spontaneously open channels.
This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.
glutamate receptor, ionotropic, delta 1
, glutamate receptor delta-1 subunit
, ionotropic glutamate receptor subunit Delta1
, glutamate receptor delta-1 subunit-like
, gluR delta-1 subunit
, glutamate receptor ionotropic, delta-1