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Glutamate Receptor, Metabotropic 7 Proteins (GRM7)

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping GRM7 Antibodies (109) and GRM7 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRM7 2917 Q14831
GRM7 108073 Q68ED2
Rat GRM7 GRM7 81672 P35400
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Top GRM7 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

GRM7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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Mouse (Murine) ,
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More Proteins for Glutamate Receptor, Metabotropic 7 (GRM7) Interaction Partners

Human Glutamate Receptor, Metabotropic 7 (GRM7) interaction partners

  1. Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population

  2. Glutamate (show GRIN1 Proteins) system genes have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium.

  3. results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population.

  4. results reported here do not support a role for GRM7 in ADHD

  5. Copy number variants at GRM7 may have a role in the etiology of bipolar disorder.

  6. For neither PCLO nor GRM7 we found a more associated variant. For SLC6A4 (show SLC6A4 Proteins), we found a new SNP that showed a lower P-value than in the GAIN-MDD GWAS

  7. in an elderly male Han Chinese population, GRM7 SNP rs11928865 (TT) occurs more frequently in age-related hearing impairment patients with SL and AL phenotype patterns.

  8. These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population

  9. Mixed modeling analyses explored the relationship of GRM7 haplotype and SNP genotypes with measures of auditory perception. GRM7 alleles are associated primarily with peripheral measures of hearing loss, and with speech detection in older adults.

  10. Copy number variations within GRM7 are not associated with schizophrenia in the Han Chinese population.

Mouse (Murine) Glutamate Receptor, Metabotropic 7 (GRM7) interaction partners

  1. Analysis of mGluR7 (show GRM2 Proteins) KO mice, c-Fos expression, and cerebral MMPIP microinjection indicate that inhibition of mGluR7 (show GRM2 Proteins) impairs intermale aggression owing to information processing dysfunction within the bed nucleus of the stria terminalis

  2. muscle does not appear to require high levels of SMN (show STMN1 Proteins) above what is produced by two copies of SMN2 (show SMN1 Proteins)

  3. SAM68 (show KHDRBS1 Proteins) is a physiological regulator of SMN2 (show SMN1 Proteins) splicing in a spinal muscular atrophy mouse model.

  4. Hyperoxia treatment increased the inclusion of SMN2 (show SMN1 Proteins) exon 7 in skeletal muscles and resulted in improved motor function.

  5. Elfn1 (show ELFN1 Proteins) recruits mGluR7 (show GRM2 Proteins) to synaptic sites.A trans interaction of Elfn1 (show ELFN1 Proteins) and mGluR7 (show GRM2 Proteins) controls targeted interneuron synapse development.

  6. GRM7 regulates the phosphorylation of CREB (show CREB1 Proteins) protein and the expression of Yes-associated protein (YAP (show YAP1 Proteins)) by directly interacting with CaM (show Calm2 Proteins), which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development.

  7. Modeling the selective interaction between XAP044 and mGlu7's Venus flytrap domain, whose three-dimensional structure is already known, will facilitate future drug development supported by computer-assisted drug design

  8. The data of this study revealed very different roles for mGlu7 in amygdala synaptic transmission, fear learning and its expression

  9. These data suggest targeting mGlu7 receptors with selective antagonist drugs may be an effective and safe strategy for the treatment of anxiety disorders.

  10. Glutamate (show GRIN1 Proteins) release mediated by GluR7 (show GRIK3 Proteins) at nerve terminals is influenced by divalent calcium channel type Ca2 (show CA2 Proteins)+ ionophore.

GRM7 Protein Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GRM7

  • glutamate receptor, metabotropic 7 (GRM7)
  • metabotropic glutamate receptor 7 (MGLUR7)
  • glutamate receptor, metabotropic 7 (Grm7)
  • 6330570A01Rik protein
  • BB176677 protein
  • C030018L03 protein
  • E130018M02Rik protein
  • GLUR7 protein
  • Gpr1g protein
  • Gprc1g protein
  • MGLU7 protein
  • mGluR7 protein

Protein level used designations for GRM7

metabotropic glutamate receptor 7 , mGluR7 , G protein-coupled receptor GRM7 , G protein-coupled receptor, family C, group 1, member G , mGlu7a receptor , metabotropic glutamate receptor mGluR7 , metabotropic glutamate receptor subtype 7b

GENE ID SPECIES
535362 Bos taurus
100171884 Pongo abelii
443520 Ovis aries
2917 Homo sapiens
108073 Mus musculus
81672 Rattus norvegicus
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