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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Additionally we are shipping Glutathione S-Transferase mu 3 (Brain) Antibodies (47) and Glutathione S-Transferase mu 3 (Brain) Kits (4) and many more products for this protein.
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The individuals carrying the deletions of GSTM1 (show GSTM1 Proteins) and GSTT1 (show GSTT1 Proteins) were at risk for Neurocysticercosis (NCC (show SLC12A3 Proteins)). Genetic variants of GSTM3 and GSTP1 (show GSTP1 Proteins) were not associated with NCC (show SLC12A3 Proteins).
Expression of GSTM3 might be regulated by epigenetic changes in lens tissue. Hypermethylation in GSTM3 promoter and altered histone modification might have a role in the ARC (show NOL3 Proteins) formation.
This meta-analysis suggested that the GSTT1 (show GSTT1 Proteins) and GSTM3 polymorphisms might influence osteosarcoma risk.
No associations between the GSTT1, GSTP1, and GSTM3 genotypes and neoplasia risk were observed. In conclusion, we determined the genotype distribution of GST polymorphisms in control subjects and breast cancer patients from northeastern Mexico.
NSD1 interacted with RNAPII and bound to GSTM3 -63A/C TATA box.
To identify the genotypes of CYP1A1 (show CYP1A1 Proteins), GSTM1 (show GSTM1 Proteins), GSTM3, GSTT1 (show GSTT1 Proteins) and GSTP1 (show GSTP1 Proteins) in a case-control study.
All three markers correlated significantly with regional lymph node metastasis: FXYD3 (show FXYD3 Proteins) (p = 0.0110), S100A11 (show S100A11 Proteins) (p = 0.0071), and GSTM3 (p = 0.0173) in colon cancer lymphatic metastasis.
This meta-analysis suggests that the GSTM3 A/B polymorphism may be an important protective factor for head and neck cancer, especially of laryngeal cancer and Caucasian populations.
rs1332018 genetic variants in the GSTM3 promoter predispose the host to downregulating GSTM3 expression in kidney, facilitate carcinogenesis, and predict an unfavourable postoperative prognosis of renal cell carcinoma (show MOK Proteins).
In conclusion, this epistatic interaction showed a high degree of consistency when stratifying by sex, the epsilon4 allele of apolipoprotein E (show APOE Proteins) genotype, and geographic region.
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (show NFE2L2 Proteins) regulation: cytochrome CYP2A5, GSTM3, GSTM1 (show GSTM1 Proteins), ENTPD5 (show ENTPD5 Proteins),UDPGDH (show UGDH Proteins), and EPHX1 (show EPHX1 Proteins).
Data show that beta-catenin (show CTNNB1 Proteins) accumulation increases GST activity in nuclei of HCC (show FAM126A Proteins) cells, and suggest that GSTM3 may be a novel target gene of the beta-catenin (show CTNNB1 Proteins)/Tcf (show HNF4A Proteins)-Lef complex.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.
glutathione S-transferase M3 (brain)
, glutathione S-transferase M3
, glutathione S-transferase M4
, glutathione S-transferase Mu 3
, glutathione S-transferase Yb4
, GST class-mu 3
, S-(hydroxyalkyl)glutathione lyase M3
, brain GST
, brain type mu-glutathione S-transferase
, glutathione S-alkyltransferase M3
, glutathione S-aralkyltransferase M3
, glutathione S-aryltransferase M3
, glutathione S-transferase, Mu-3
, glutathione S-transferase mu 3
, glutathione-S-transferase, mu
, glutathione S-transferase GT9.3