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a NGF-gated Ca2+ channel involved in neuronal differentiation. Additionally we are shipping Glycoprotein M6A Proteins (5) and Glycoprotein M6A Kits (2) and many more products for this protein.
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Human Polyclonal GPM6A Primary Antibody for EIA, IHC (p) - ABIN952592
Boks, Hoogendoorn, Jungerius, Bakker, Sommer, Sinke, Ophoff, Kahn: Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008
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Human Polyclonal GPM6A Primary Antibody for ELISA, WB - ABIN4315546
Morrison, Felix, Cupples, Glazer, Loehr, Dehghan, Demissie, Bis, Rosamond, Aulchenko, Wang, Haritunians, Folsom, Rivadeneira, Benjamin, Lumley, Couper, Stricker, ODonnell, Rice, Chang, Hofman, Levy et al.: Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. ... in Circulation. Cardiovascular genetics 2010
Mouse (Murine) Monoclonal GPM6A Primary Antibody for IHC (fro) - ABIN1107419
Alfonso, Fernández, Cooper, Flugge, Frasch: The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation. in Proceedings of the National Academy of Sciences of the United States of America 2005
For the methylation of adenosine in RNA, Mettl3 (show METTL3 Antibodies) is the catalytically active subunit, while Mettl14 (show METTL14 Antibodies) plays a structural role critical for substrate recognition.
METTL3 (show METTL3 Antibodies) enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.
miR (show MLXIP Antibodies)-33a can attenuatenon-small-cell lung carcinoma cells proliferation via targeting to the 3'-untranslated region of METTL3 (show METTL3 Antibodies) mRNA.
Structure of the METTL3 (show METTL3 Antibodies)-METTL14 (show METTL14 Antibodies) complex
findings thus indicate a critical role of correct GPM6A/M6 levels for cognitive function and support a role of the GPM6A duplication for the patient's phenotype
Data indicate that neuronal membrane glycoproteins GPM6A and GPM6B (show GPM6B Antibodies) may act as novel oncogenes in the development of lymphoid leukemia.
Study identifies m(6)A methylation sites on many clock gene transcripts and shows that specific inhibition of m(6)A methylation by silencing of the m(6)A methylase Mettl3 (show METTL3 Antibodies) is sufficient to elicit circadian period elongation and RNA processing delay.
loosing dynamic regulation of neuronal GPM6A expression poses a genetic risk for claustrophobia
Results indicate that M6a modulates mu-opioid receptor (show OPRM1 Antibodies) endocytosis and post-endocytotic sorting and has an important role in receptor regulation.
Results suggest that expression level of GPM6A is associated with the differentiation and neuronal migration of neurons derived from undifferentiated human embryonic stem cells.
GPM6a induces the clustering of lipid rafts and acts as a signal transducer that responds to extracellular signals.
This study demonistrated that M6a is essential for the support of neurite extension in developmental brain.
this study identifies Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency.
analysis of actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a
M6a-deficient axons grow actively but are not growth suppressed by antibodies bound to four-transmembrane actin-based glycoprotein M6a concentrated on the edge of the axon growth cone.
expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b (show LMX1B Antibodies), En1 (show EN1 Antibodies), Pax2 (show PAX2 Antibodies), Pax5 (show PAX5 Antibodies), Sox1 (show SOX1 Antibodies), Sox2 (show SOX2 Antibodies), and Wnt1 (show WNT1 Antibodies)), and also the number of neural stem cells (NSC) derived from D3mshM6A cells
These results suggest that M6a plays a role in retinal development by regulating neurites, and it may also function to modulate synaptic activities in the adult retina.
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
neuronal membrane glycoprotein M6-a
, neuronal proteolipid GPM6A
, glycoprotein M6A
, N6-adenosine-methyltransferase 70 kDa subunit
, adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
, mRNA m(6)A methyltransferase
, methyltransferase-like protein 3
, m6a methyltransferase
, methyltransferase-like 3