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The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. Additionally we are shipping GOLPH3 Antibodies (76) and GOLPH3 Proteins (5) and many more products for this protein.
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The current study found that GOLPH3, an outer membrane protein (show SYNJ2BP ELISA Kits) of the Golgi complex, was significantly upregulated in N2A cells upon oxygen-glucose deprivation and reoxygenation.
Results provide evidences that overexpression of GOLPH3 stimulates EMT (show ITK ELISA Kits) via the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway, which further promotes metastasis of epithelial ovarian cancer.
GOLPH3 levels may be a novel prognostic biomarker of tobacco related lung disease.
Authors confirm that the decrease of GOLPH3 that promotes the apoptosis of glioma cells may be regulated by the activation of NDRG1 and cleaved capcase 3. There was a inverse association between GOLPH3 and NDRG1 in glioma samples.
Data found that miR (show MLXIP ELISA Kits)-134 was highly downregulated in gastric cancer tissues and cell lines and inversely correlated with GOLPH3. These results suggest that miR (show MLXIP ELISA Kits)-134 regulates gastric cancer cell proliferation, at least potentially, through downregulation of the GOLPH3 gene, implicating a candidate tumor-suppressor miRNA in the pathogenesis of gastric cancer.
In this review, we will explore the cellular functions regulated by GOLPH3 and discuss if and how they contribute to the oncogenic activity of this intriguing Golgi localized oncoprotein.
cumulative evidence indicates that GOLPH3 participates in several cellular processes critical for cancer cells, emerging as an attractive therapeutic target
GOLPH3 overexpression may participate in the occurrence and development of colorectal carcinoma by inhibiting apoptosis and promoting angiogenesis.
Results show that high GOLPH3 and nuclear/cytoplasmic YB-1 (show YBX1 ELISA Kits) expression correlated with a poor prognosis in patients with prostate cancer.
Review/Meta-analysis: overexpression of GOLPH3 predicts poor prognosis in solid tumors.
GOLPH3 is likely to play important roles in bladder cancer progression via modulating AKT (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) signaling, and it is a novel prognostic biomarker and promising therapeutic target for bladder cancer.
The selective S-nitrosylation of EMMPRIN and GOLPH3 at the Golgi apparatus in endothelial cells results from the physical proximity to eNOS (show NOS3 ELISA Kits)-derived nitric oxide.
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.
golgi phosphoprotein 3
, Golgi phosphoprotein 3
, coat protein GPP34
, golgi peripheral membrane protein 1, 34 kDa
, golgi protein
, golgi-associated protein
, mitochondrial DNA absence factor
, trans-Golgi protein GMx33