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GGA3 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. Additionally we are shipping GGA3 Proteins (5) and GGA3 Kits (3) and many more products for this protein.
Showing 10 out of 56 products:
Chimpanzee Polyclonal GGA3 Primary Antibody for EIA, WB - ABIN401317
Puertollano, Aguilar, Gorshkova, Crouch, Bonifacino: Sorting of mannose 6-phosphate receptors mediated by the GGAs. in Science (New York, N.Y.) 2001
Show all 7 references for ABIN401317
Mouse (Murine) Polyclonal GGA3 Primary Antibody for IHC, WB - ABIN350341
Doray, Bruns, Ghosh, Kornfeld: Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 5 references for ABIN350341
Human Monoclonal GGA3 Primary Antibody for IF, WB - ABIN968814
Boman, Zhang, Zhu, Kahn: A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi. in Molecular biology of the cell 2000
Show all 3 references for ABIN968814
Human Polyclonal GGA3 Primary Antibody for WB - ABIN2786200
Wang, Sun, Macia, Kirchhausen, Watson, Bonifacino, Yin: PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. in Molecular biology of the cell 2007
Human Polyclonal GGA3 Primary Antibody for ELISA, WB - ABIN185453
Prag, Lee, Mattera, Arighi, Beach, Bonifacino, Hurley: Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins. in Proceedings of the National Academy of Sciences of the United States of America 2005
depletion of GGA1 (show GGA1 Antibodies) and GGA3 engender a rapid and robust elevation of BACE1 (show BACE Antibodies) in the acute phase after brain injury. However, the efficient disposal of the acutely accumulated BACE1 (show BACE Antibodies) solely depends on GGA3 levels in the subacute phase of injury
GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery
role of GGA3 in the cell surface export of alpha2B (show ADRA2B Antibodies)-adrenergic receptor
These data indicate that clathrin is required for the function of AP-1 (show FOSB Antibodies)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.
GGA3 is involved in the cellular processes relevant for Alzheimer's disease pathogenesis.
Subcellular fractionation of Alzheimer's disease cortex with low levels of Golgi-localized GGA proteins shows an alteration of beta-secretase distribution and extensive co-localization with amyloid beta precursor protein APP (show APP Antibodies).
structures of the VHS domain of human GGA3 complexed with signals from both mannose-6-phosphate receptors
These results indicate that GGA3-S is predominantly expressed in human tissues except the brain and in cell lines.
RNAi of GGA3 expression results in accumulation of the cation-independent mannose 6-phosphate receptor (show IGF2R Antibodies) and internalized epidermal growth factor (EGF (show EGF Antibodies)) within enlarged early endosomes. This perturbation impairs the degradation of internalized EGF (show EGF Antibodies).
found that the human GGA3 protein GAT domain contains two ubiquitin binding motifs that bind to the same surface of ubiquitin
crystal structure of the GAT domain
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene.
ADP-ribosylation factor-binding protein GGA3
, golgi-localized, gamma ear-containing, ARF-binding protein 3
, Golgi-localized, gamma ear-containing, ARF-binding protein 3
, golgi associated, gamma adaptin ear containing, ARF binding protein 3
, ADP-ribosylation factor binding protein 3