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The protein encoded by GAP43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. Additionally we are shipping GAP43 Antibodies (285) and GAP43 Kits (45) and many more products for this protein.
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Findings show high level of both YKL-40 (show CHI3L1 Proteins) and GAP-43 in CSF (show CSF2 Proteins) of older women with suicidal ideation which suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults.
associations of neuromodulin and neurogranin (show NRGN Proteins) to Alzheimer's disease
Copy-number variations are enriched for GAP43 and other neurodevelopmental genes in children with developmental coordination disorder.
Downregulation of GAP43 promotes gliomas.
The peripheral neuropathies lead to an initial increase in GAP-43 gene expression as a potential mechanism of regeneration, which is not sustained in neuropathies of long duration.
Results show that PKC (show PRRT2 Proteins)-dependent phosphorylation of GAP43 plays a critical role in regulating postsynaptic gephyrin (show GPHN Proteins) aggregation in developing GABAergic synapses.
increased expression of TH and GAP43 might be a molecular mechanism for left atrial myoelectricity remodeling of aging atrial fibrillation patients, which might be potential therapeutic targets of atrial fibrillation.
GAP43 is seemingly a highly sensitive marker for peripheral nerve sheath tumors
The results showed that the decreased GAP-43 levels induced by glutamate (show GRIN1 Proteins) could be partially reversed by the presence of NRG-1beta
Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 (show LYPLA1 Proteins) and acyl-protein thioesterase-2 (show LYPLA2 Proteins) with that of proto-oncogene (show RAB1A Proteins) H-ras (show HRAS Proteins) product and growth-associated protein-43
hnRNP (show HNRNPH2 Proteins)-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for regulating GAP-43 expression and function and may be critical for neuronal development.
The GASP (show GPRASP1 Proteins)-43 is involves in the orientation of cell division by interacting with Galphai.
Trimethyltin decreased synaptophysin (show SYP Proteins) but not GAP-43 expression in the mouse hippocampus.
Antiretroviral drugs may recruit the HuD (show ELAVL4 Proteins)-GAP43 pathway, potentially contributing to a response to the antiretroviral neuronal toxicity.
KSRP (show KHSRP Proteins) modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
these findings suggest that GAP-43 is dynamically involved in early postnatal and adult hippocampal neurogenesis and synaptic connectivity, possibly contributing to the GAP-43+/- behavioral phenotype.
In this review, GAP-43 in vivo knockdown in olivary neurons leads to the atrophy of their climbing fibers and a reduction in the ability to sprout toward surrounding denervated Purkinje cells.
GAP-43 is required to sustain synaptic stability and promote the initiation of axonal regrowth
In vitro results indicated that GAP43 is indeed expressed in both myoblasts and differentiating myotubes, and its cellular localization changes dramatically during maturation.
Initial emergence of hollows in the somatosensory cortex is no different between GAP43 heterozygous mice and nonheterozygous littermate controls; however, the emergence of sides and septa (show SEPT2 Proteins) is delayed by 2 days.
these results and GAP43 structural features, support an involvement of the protein in the dynamic intracellular Ca2 (show CA2 Proteins)+ homeostasis, a common conserved role among the different species.
The results implicate the GAP43 pathway as part of an F-actin based mechanism that both stabilizes new synapses and initiates new branches near effective synapses.
The present data strongly suggest that phospho-GAP43 plays an active role in both the early and late stages of optic nerve regeneration in fish.
Both the synthetic N-terminal peptide GAP-43(1-40) and the brain-derived fragment GAP-43-3 preserved the ability to oligomerize under the action of acidic phospholipids and SDS (show SDS Proteins).
These results indicated the interaction of GAP-43 and Galpha(o (show GNAO1 Proteins)) could accelerate conversion of depalmitoylated Galpha(o (show GNAO1 Proteins)) but not palmitoylated Galpha(o (show GNAO1 Proteins)) from oligomers to monomers, so as to increase the GTPgammaS binding activity of Galpha(o (show GNAO1 Proteins)).
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
growth associated protein 43
, axonal membrane protein GAP-43
, brain abundant, membrane attached signal protein 2
, growth accentuating protein 43
, growth-associated protein 43
, protein F1
, calmodulin-binding protein P-57
, nerve growth-related peptide GAP43
, neural phosphoprotein B-50
, neuron growth-associated protein 43
, growth associated protein 43 a
, growth associated protein 43 b