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GREB1 is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway.
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greb1 mutation reduces pituitary hormone (show CGA Antibodies) expression and causes significant growth defects.
the GREB1 region on chromosome 2p25.1 and the GREB1 gene may play a role in endometriosis risk
GREB1 is a critical mediator of both the estrogen-stimulated proliferation of breast cancer cells and the androgen-stimulated proliferation of prostate cancer cells
The expression of Greb1 was up-regulated in mouse tumors treated with E2 and was overexpressed in human ovarian cancers relative to human ovarian surface epithelium, suggesting a role for GREB1 in human ovarian tumor progression.
RAD54B and GREB1 gene polymorphisms may not be associated with PCOS in the Han Chinese population.
GREB1 is one of the central estrogen-specific ER cofactors, where it functions to mediate interactions between the ER and additional proteins.
GREB1 alpha mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis.
in ER-positive breast cancer cells, LRH-1 (show NR5A2 Antibodies) promotes cell proliferation by enhancing ERalpha (show ESR1 Antibodies) mediated transcription of target genes such as GREB-1
Tissue expression of GREB1 is associated with organ-confined prostate cancer and may constitute a gene associated with a favorable prognosis.
Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF (show IL10 Antibodies) and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN (show PTPRN Antibodies) and GUCY2C (show GUCY2C Antibodies)).
Characterize a monoclonal antibody that recognizes GREB1 protein in breast cancer cells.
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, gene regulated by estrogen in breast cancer
, gene regulated in breast cancer 1 protein