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The protein encoded by E2IG3 may interact with p53 and may be involved in tumorigenesis. Additionally we are shipping Guanine Nucleotide Binding Protein-Like 3 (Nucleolar) Proteins (6) and Guanine Nucleotide Binding Protein-Like 3 (Nucleolar) Kits (3) and many more products for this protein.
Showing 10 out of 135 products:
Mouse (Murine) Polyclonal E2IG3 Primary Antibody for WB - ABIN1881380
Hirai, Romanova, Kellner, Verma, Rayner, Asakura, Kikyo: Post-mitotic role of nucleostemin as a promoter of skeletal muscle cell differentiation. in Biochemical and biophysical research communications 2010
Show all 5 Pubmed References
Human Monoclonal E2IG3 Primary Antibody for BI, IHC (f) - ABIN2689866
Kafienah, Mistry, Williams, Hollander: Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow. in Stem cells (Dayton, Ohio) 2006
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Human Polyclonal E2IG3 Primary Antibody for IHC (p), IP - ABIN151112
Okamoto, Yasukawa, Nguyen, Kasim, Maida, Possemato, Shibata, Ligon, Fukami, Hahn, Masutomi: Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. in Proceedings of the National Academy of Sciences of the United States of America 2011
Show all 2 Pubmed References
Human Monoclonal E2IG3 Primary Antibody for ELISA, WB - ABIN1724769
Meng, Hsu, Tsai: GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest. in Oncogene 2011
Human Polyclonal E2IG3 Primary Antibody for ELISA, WB - ABIN4341079
Yoshida, Fujimoto, Kudoh, Nagata, Nakayama, Shinohara, Ito: Nucleostemin affects the proliferation but not differentiation of oral squamous cell carcinoma cells. in Cancer science 2011
The nucleolar GTP-binding (show RND2 Antibodies) proteins Gnl2 (show GNL2 Antibodies) and nucleostemin are required for retinal neurogenesis in developing zebrafish.
In addition, migration and invasion demonstrated significant inhibition in Nucleostemin-deficient cells. Furthermore, the knockdown of Nucleostemin dramatically suppressed xenograft progression in BALB/c nude mice. Our findings suggest that Nucleostemin is associated with malignancy in an ovarian cancer SKOV-3 cell line.
Identified a positive correlation between up-regulation of nucleostemin and human glioma cell proliferation and that knocking-down nucleostemin alleviated glioma proliferation by reducing beta-Catenin (show CTNNB1 Antibodies) transportation into the nucleus.
Relative expression of GNL3 in synovial tissue and fluid samples was significantly higher in the osteoarthritic group as compared to the non-osteoarthritic group.
The expression level of GNL3 was examined in 89 human gastric cancer samples using immunohistochemistry (IHC) staining. GNL3 in gastric cancer tissues was significantly upregulated compared with paracancerous tissues.
over-expression of GNL3 and SKA3 (show SKA3 Antibodies) in the PC-3 (show PCSK1 Antibodies) human prostate cancer cell line decreased in vitro cell migration and invasion
p53 (show TP53 Antibodies) activation by inauhzin via inhibiting SIRT1 (show SIRT1 Antibodies), also inhibits cellular IMPDH2 (show IMPDH2 Antibodies) activity, reduces the levels of cellular GTP (show AK3 Antibodies) and GTP-binding (show RND2 Antibodies) nucleostemin, thus representing in a new anti-cancer strategy.
overexpression of NS suppressed ARF (show CDKN2A Antibodies) polyubiquitination by its E3 ligase Ubiquitin Ligase for ARF (show CDKN2A Antibodies) and elongated its half-life, whereas knockdown of NS led to the decrease of ARF (show CDKN2A Antibodies) levels
Silence of nucleostemin inhibit cell proliferation through up-regulating p21 (show CDKN1A Antibodies) expression and nucleostemin may be involved in the pathogenesis of esophageal squamous cell carcinoma.
It is concluded that nucleostemin expression could not be specific in a certain type of cells in colon cancer cell line HT29.
Data shows that the NS protein expression status was positively correlated with both ER and HER2 (show ERBB2 Antibodies) status and was a powerful prognostic factor.
Nucleostemin expression participates in the preservation of the viability and integrity of embryonic stem cells.
nucleostemin protects hematopoietic stem cells (HSCs) from DNA damage accumulation and is required for the maintenance of HSCs.
Mechanistic studies performed in mouse embryonic fibroblast cells showed that loss of nucleostemin triggers DNA damage and growth arrest independently of the p53 (show TP53 Antibodies) status or rRNA synthesis
Nucleostemin in the maintenance of ESC self-renewal, demonstrate the importance of rapid transit through G1 for this process, and expand the known classes of reprogramming factors.
NS functions downstream of Myc (show MYC Antibodies) as a rate-limiting regulator of cell proliferation and transformation.
NS undergoes a ubiquitin- and MDM2 (show MDM2 Antibodies)-independent proteasomal degradation when intracellular GTP (show AK3 Antibodies) levels are markedly reduced
a complex composed of TERT (show TERT Antibodies), BRG1 (show SMARCA4 Antibodies), and NS/GNL3L (show GNL3L Antibodies) maintains the function of tumor initiating cells
Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
analysis of nucleolar localization of stem cell protein (show TAL1 Antibodies) nucleostemin
Nucleostemin has a unique ability, derived from an ancestral function, to control the proliferation rate of stem/progenitor cells in vivo independently of p53.
Nucleostemin functions in early amphibian development to control cell proliferation of neural progenitor cells.
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.
guanine nucleotide-binding protein-like 3
, nucleostemin-like protein
, guanine nucleotide binding protein-like 3 (nucleolar)
, guanine nucleotide-binding protein-like 3-like
, E2-induced gene 3 protein
, estradiol-induced nucleotide binding protein
, novel nucleolar protein 47
, nucleolar GTP-binding protein 3