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Guanylate Cyclase 1, Soluble, alpha 3 Proteins (GUCY1A3)

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. Additionally we are shipping GUCY1A3 Antibodies (45) and GUCY1A3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GUCY1A3 2982 Q02108
GUCY1A3 60596 Q9ERL9
GUCY1A3 497757  
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Top GUCY1A3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,007.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GUCY1A3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Guanylate Cyclase 1, Soluble, alpha 3 (GUCY1A3) Interaction Partners

Human Guanylate Cyclase 1, Soluble, alpha 3 (GUCY1A3) interaction partners

  1. Expression of the alpha1-A680T sGC (show SGCB Proteins) variant in reporter cells resulted in higher cyclic guanosine monophosphate production compared with the wild-type enzyme and the purified alpha1-A680T sGC (show SGCB Proteins) exhibited enhanced sensitivity to nitric oxide in vitro.

  2. Dynamic interplay between hsp90 (show HSP90 Proteins), apo (show C9orf3 Proteins)-sGC (show SGCB Proteins)-beta1, and sGC (show SGCB Proteins)-alpha1 in response to NO is unprecedented and represent new steps by which cells can modulate the heme content and activity of sGC (show SGCB Proteins) for signaling cascades.

  3. ZNF280B (show ZNF280B Proteins) upregulates GUCY1A3 expression and downregulates TP53 (show TP53 Proteins) in prostate cancer cells.

  4. homozygous mutations in GUCY1A3, which encodes the alpha1 subunit of soluble guanylate cyclase, the major receptor for nitric oxide, might play a role in moyamoya and achalasia

  5. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase

  6. GCS-alpha-1 regulation of p53 (show TP53 Proteins) activity is important in prostate cancer biology and may represent an important mechanism of p53 (show TP53 Proteins) down-regulation.

  7. We concluded that the alpha-subunit (show POLG Proteins) and the beta(1)(191-619) domain exert structural strains on the heme domain.

  8. analysis of pharmacological response to direct sGC (show SGCB Proteins) activators in coronary artery disease patients

  9. A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase

  10. C-alpha1 sGC (show SGCB Proteins) splice form is expressed at high levels in differentiating cells and its intracellular distribution varies from canonical alpha1 sGC (show SGCB Proteins) subunit.

Mouse (Murine) Guanylate Cyclase 1, Soluble, alpha 3 (GUCY1A3) interaction partners

  1. The authors elucidated this dependency by showing that guanylate cyclase-1 is a novel rhodopsin-binding protein.

  2. Cellular markers revealed that vascular SMC (show DYM Proteins) differentiation decreased, whereas myofibroblast activation increased in the hyperoxic sGC (show NPR1 Proteins)-alpha1 KO pup lung.

  3. Soluble guanylate cyclase alpha1-deficient mice: a novel murine model for primary open angle glaucoma.

  4. Male mice deficient in a NO receptor component, the alpha1 subunit of soluble guanylate cyclase (sGCalpha1), are prone to hypertension in some, but not all, mouse strains, suggesting that additional genetic factors contribute to the onset of hypertension

  5. These data suggests a novel physiological role for PDE5 (show PDE5A Proteins) in restricting the effects of NOS3 (show NOS3 Proteins)/sGC (show NPR1 Proteins)/PKG (show PRKG1 Proteins) signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC (show NPR1 Proteins)]

  6. Pressure overload results in translocation of sGC (show NPR1 Proteins) out of membrane microdomains, depressing NO/heme-dependent activation in the heart, consistent with enhanced oxidation.

  7. findings identify a crucial role of the NO/sGCalpha1beta1/cGMP pathway in modulating lymphatic vessel function [soluble guanylate cyclase alpha1beta1]

  8. RD3 (show RD3 Proteins) mediates the export of GC1 from the endoplasmic reticulum to endosomal vesicles, and that the C terminus of GC1 is required for RD3 (show RD3 Proteins) binding

  9. TGF-beta(1 (show TGFB1 Proteins)) decreased sGC (show NPR1 Proteins) and PKGI (show PRKG1 Proteins) expression in pulmonary artery and aortic smooth muscle cells from adult rats and mice.

  10. Requirement of both alpha-2 and alpha-1 guanylate cyclases for signaling in long-term potentiation (LTP (show SCP2 Proteins)) indicates the existence of two distinct nitric oxide/cGMP-mediated pathways, which have to work in concert for expression of LTP (show SCP2 Proteins).

Cow (Bovine) Guanylate Cyclase 1, Soluble, alpha 3 (GUCY1A3) interaction partners

  1. We concluded that the alpha-subunit (show POLG Proteins) and the beta(1)(191-619) domain exert structural strains on the heme domain.

  2. The N-terminal region of nitric oxide-sensitive guanylyl cyclase alpha 1 subunit(amino acids 61-128) is mandatory for quantitative dimerization.

GUCY1A3 Protein Profile

Protein Summary

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with GUCY1A3

  • guanylate cyclase 1, soluble, alpha 3 (GUCY1A3)
  • guanylate cyclase 1, soluble, alpha 3 (gucy1a3)
  • si:dkey-264b2.3 (si:dkey-264b2.3)
  • guanylate cyclase 1, soluble, alpha 3 (LOC100223563)
  • soluble guanylyl cyclase alpha subunit (gucy1a3)
  • guanylate cyclase 1, soluble, alpha 3 (Gucy1a3)
  • 1200016O07Rik protein
  • GC-SA3 protein
  • GUC1A3 protein
  • GUCA3 protein
  • GUCSA3 protein
  • Gucy1a1 protein
  • gucy1a3 protein
  • im:7136149 protein
  • SGC protein
  • sgc1a1 protein
  • zgc:112159 protein

Protein level used designations for GUCY1A3

guanylate cyclase 1, soluble, alpha 3 , guanylate cyclase soluble subunit alpha-3 , soluble guanylate cyclase large subunit alpha 1 , soluble guanylate cyclase 1 alpha 3 , si:dkey-264b2.3 , guanylate cyclase soluble subunit alpha-3-like , soluble guanylyl cyclase alpha subunit , GC-S-alpha-1 , GCS-alpha-1 , GCS-alpha-3 , soluble guanylate cyclase large subunit , alpha 1 sGC , Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase) , Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase) , NO-sensitive GC alpha 1 subunit , guanylate cyclase soluble subunit alpha-1 , larger subunit of soluble guanylyl cyclase , nitric oxide-sensitive guanylyl cyclase alpha 1 subunit

GENE ID SPECIES
422407 Gallus gallus
550420 Danio rerio
553100 Sus scrofa
699365 Macaca mulatta
100017038 Monodelphis domestica
100069573 Equus caballus
100150025 Danio rerio
100172608 Pongo abelii
100223563 Taeniopygia guttata
100294641 Ovis aries
100396127 Callithrix jacchus
100547213 Meleagris gallopavo
100581660 Nomascus leucogenys
100608597 Pan troglodytes
100049177 Oryzias latipes
2982 Homo sapiens
60596 Mus musculus
497757 Rattus norvegicus
482663 Canis lupus familiaris
281216 Bos taurus
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