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E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Additionally we are shipping HECW2 Antibodies (47) and many more products for this protein.
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This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified.
Low HECW2 expression is associated with cervical cancer.
NEDL2 is a novel substrate of APC (show APC Proteins)/C-Cdh1 (show CDH1 Proteins) as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition
NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt (show AKT1 Proteins) signaling pathway.
Grk2 (show ADRBK1 Proteins) phosphorylates the C terminus of the Na-channel beta subunit (show POLG Proteins) and renders the channels insensitive to inhibition by Nedd4-2 (show NEDD4L Proteins)
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity).
E3 ubiquitin-protein ligase HECW2
, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
, E3 ubiquitin-protein ligase HECW2-like
, e3 ubiquitin-protein ligase HECW2-like
, HECT, C2 and WW domain-containing protein 2
, NEDD4-like E3 ubiquitin-protein ligase 2
, NEDD4-related E3 ubiquitin ligase NEDL2