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HESX1 encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Additionally we are shipping HESX Homeobox 1 Proteins (19) and HESX Homeobox 1 Kits (2) and many more products for this protein.
Showing 10 out of 26 products:
A novel heterozygous mutation in the HESX1 gene and a novel homozygous mutation in the PROP1 (show PROP1 Antibodies) gene were detected in 2 pedigrees with combined pituitary hormone (show CGA Antibodies) deficiency
investigated the specific mutations in PROP1 (show PROP1 Antibodies), POU1F1 (show POU1F1 Antibodies), LHX3 (show LHX3 Antibodies), and HESX1 genes in patients with combined pituitary hormone (show CGA Antibodies) deficiency (CPHD) in Turkey
Data indicate that HESX1, LHX4 (show LHX4 Antibodies) and SOX3 (show SOX3 Antibodies) polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).
expand the phenotypic spectrum of HESX1 mutations in Kallman syndrome.
Data show no mutations in HESX1, PROP1 (show PROP1 Antibodies), and POU1F1 (show POU1F1 Antibodies) genes, seven different mutations in CTNNB1 (show CTNNB1 Antibodies) in 8/16 patients, and hyperexpression of miR (show MLXIP Antibodies)-150.
A c.357+3G>A mutation prevents the generation of one of the alternative isoforms normally produced by the wild-type allele, predicting a truncated HESX1 protein.
A novel HESX1 causative mutation was found in a consanguineous family, and two LHX4 (show LHX4 Antibodies) mutations were present in familial Pituitary stalk interruption syndrome.
Mutations in the PROP1 (show PROP1 Antibodies) and HESX1 genes were not identified in these patients with sporadic growth hormone (show GH1 Antibodies) defiency, combined pituitary hormone (show CGA Antibodies) deficiency and septo-optic dysplasia.
A large cohort of patients with schizencephaly, some with features of septo-optic dysplasia, were sequenced for mutations in LHX2 (show LHX2 Antibodies), HESX1 and SOX2 (show SOX2 Antibodies).
Studies suggest that TLE1 (show TLE1 Antibodies) and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1 (show PROP1 Antibodies).
Hesx1 plays a significant role in sustaining pluripotency in embryonic stem cells.Hesx1 transcriptionally suppresses differentiation-related genes.
Wnt (show WNT2 Antibodies) inhibition during the first day has larger impact on the activation of Hesx1 and Six3, suggesting that in embryos Wnt (show WNT2 Antibodies) inhibition caused by Dkk1 (show DKK1 Antibodies) contributes greatly in the establishment of the anterior forebrain precursor.
Variability in Hes1 expression therefore helps to explain why STAT3 (show STAT3 Antibodies) responsiveness varies between individual ES cells, and this in turn helps to explain why pluripotent cells commit to differentiate asynchronously..
Transcriptional profiling of anterior forebrain precursors from mouse embryos expressing eGFP from the Hesx1 locus provides molecular evidence supporting a novel function of Hesx1 in mediating repression of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) target activation.
Data suggest that formation of a heterodimer between HESX1 and PROP1 (show PROP1 Antibodies) allows HESX1 to become active, and that PROP1 (show PROP1 Antibodies) then replaces HESX1 to advance to the middle stage of pituitary development.
A novel inducible element, activated by contact with Rathke's pouch, is present in the regulatory region of the Hesx1 homeobox (show PRRX1 Antibodies) gene.
the domains of Hes-1 needed to block adipogenesis coincide with those necessary for transcriptional repression.
Conserved regulatory elements establish the dynamic expression of Rpx in early development.
The absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development.
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency.
Rathke pouch homeobox
, homeobox expressed in ES cells 1
, homeobox protein ANF
, homeobox, ES cell expressed 1
, homeo box (expressed in ES cells) 1
, homeo box gene expressed in ES cells
, anterior-restricted homeobox protein
, rathke pouch homeo box