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Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). Additionally we are shipping HRAS-Like Suppressor 2 Proteins (2) and many more products for this protein.
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Human Polyclonal HRASLS2 Primary Antibody for ELISA, IHC - ABIN449716
Shyu, Hsieh, Tsai, Wu, Jiang: Cloning and functional characterization of the HRASLS2 gene. in Amino acids 2008
Data show that acyl-modified forms of HRAS (show HRAS Antibodies)-like tumor suppressors HRASLS2 and HRASLS3 (show PLA2G16 Antibodies) mimicking lipolytic activity of lecithin retinol acyltransferase LRAT (show LRAT Antibodies).
HRASLS2 protein suppressed growth and RAS activities of cancer cells, and the C-terminal hydrophobic domain appeared to be indispensable for both activities.
The tumor suppressors TIG3, HRASLS2 and H-rev107 are involved in the phospholipid metabolism with different physiological roles.
Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC.
HRAS-like suppressor 2