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Hairy and Enhancer of Split 7 (Drosophila) Proteins (HES7)

HES7 encodes a member of the hairy and enhancer of split family of bHLH transcription factors. Additionally we are shipping HES7 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HES7 84667 Q9BYE0
HES7 84653 Q8BKT2
Rat HES7 HES7 287423  
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Top HES7 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details

HES7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

Top referenced HES7 Proteins

  1. Human HES7 Protein expressed in Escherichia coli (E. coli) - ABIN1098715 : Sparrow, Sillence, Wouters, Turnpenny, Dunwoodie: Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis. in European journal of human genetics : EJHG 2010 (PubMed)
    Show all 2 references for ABIN1098715

More Proteins for Hairy and Enhancer of Split 7 (Drosophila) (HES7) Interaction Partners

Human Hairy and Enhancer of Split 7 (Drosophila) (HES7) interaction partners

  1. an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variation

  2. mutation of HES7 is uniquely associated with defects in vertebral, heart and neural tube formation, and this observation will help provide a discriminatory diagnostic guide in patients with SCD (show SCD Proteins), as well as inform molecular genetic testing.

  3. MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.

  4. Two new missense mutations in HES7 in a family with spondylocostal dysostosis.

  5. R25W missense mutation of HES7 is causative of Spondylocostal dysostosis.

Mouse (Murine) Hairy and Enhancer of Split 7 (Drosophila) (HES7) interaction partners

  1. Lengthening the third Hes7 intron by 10 or 20 kb disrupts accurate RNA splicing and inactivates the gene.

  2. Fgf signaling was found to be a primary target for hypoxia, which causes phenotypic variations of heterozygous mutations in Hes7 or Mesp2 (show Mesp2 Proteins), suggesting gene-environment interaction through this signaling.

  3. Hes7 is a key regulator of the pace of the segmentation clock.

  4. Tbx6 (show TBX6 Proteins) and the Wnt (show WNT2 Proteins) pathway cooperatively regulate proper Hes7 expression.

  5. introns lead to an approximately 19-min delay in the Hes7 gene expression, and mathematical modeling suggested that without such a delay, Hes7 oscillations would be abolished

  6. there are differential axial requirements for lunatic fringe (show LFNG Proteins) and Hes7 transcription during mouse somitogenesis

  7. periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng (show LFNG Proteins), and this negative feedback represents a molecular basis for the segmentation clock

  8. instability of Hes7 is essential for sustained oscillation and for its function as a segmentation clock

  9. Lunatic fringe (show LFNG Proteins) and Hes7 controls their oscillatory expression during somitogenesis by forming negative feedback loop

  10. Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch (show NOTCH1 Proteins) signaling.

HES7 Protein Profile

Protein Summary

This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HES7

  • hairy and enhancer of split 7 (Drosophila) (HES7)
  • hairy and enhancer of split 7 (Drosophila) (Hes7)
  • bHLHb37 protein
  • SCDO4 protein

Protein level used designations for HES7

bHLH factor Hes7 , class B basic helix-loop-helix protein 37 , hHes7 , transcription factor HES-7 , mHes7

GENE ID SPECIES
84667 Homo sapiens
612802 Canis lupus familiaris
617638 Bos taurus
84653 Mus musculus
287423 Rattus norvegicus
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