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HPR encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Additionally we are shipping HPR Antibodies (62) and HPR Kits (36) and many more products for this protein.
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Data indicate that haptoglobin-related protein (Hpr) is presented at the surface of hepG2 cells.
Our analysis illustrates the complex interplay between functions and haplotypes of adjacent genes, environmental context and natural selection, and offers insights into potential use of haptoglobin (show HP Proteins) or haptoglobin-related protein as therapeutic agents.
No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein
recombinant Hpr binds hemoglobin (show HBB Proteins) as efficiently as haptoglobin (show HP Proteins)
apoL-I (show APOL1 Proteins) is responsible for the trypanolytic activity of normal human serum, whereas Hpr allows fast uptake of the carrier HDL (show HSD11B1 Proteins) particles in trypanolysis
Infection by Trypanosoma brucei brucei causes hemolysis that triggers activation of trypanosome lytic factor by formation of haptoglobin-related protein-hemoglobin complexes, enhancing binding, trypanolytic activity, and clearance of parasites.
at low pH. Trypanosome lytic factor, apoL-1 (show APOL1 Proteins), and apoA-1 (show APOA1 Proteins) exhibit specificity for anionic membranes, whereas Hpr permeabilizes both anionic and zwitterionic membranes.
Elimination of both HPR and PMDH in peroxisomes causes a slight decrease in the rates of photosynthesis under photorespiratory conditions. [HPR1 (show HPSE Proteins)]
The results indicate that HPR can oxidise NADH at sufficient rate in the absence of PMDH to support beta-oxidation and hence seed germination.
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer.
, Haptoglobin-related locus