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Heart and Neural Crest Derivatives Expressed 1 Proteins (HAND1)

The protein encoded by HAND1 belongs to the basic helix-loop-helix family of transcription factors. Additionally we are shipping HAND1 Antibodies (86) and HAND1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HAND1 9421 O96004
HAND1 59112 P97832
HAND1 15110 Q64279
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Top HAND1 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,476.83
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,491.50
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$2,498.83
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,531.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,535.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,541.00
Details

HAND1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced HAND1 Proteins

  1. Human HAND1 Protein expressed in Escherichia coli (E. coli) - ABIN1098692 : Scott, Anson-Cartwright, Riley, Reda, Cross: The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. in Molecular and cellular biology 2000 (PubMed)
    Show all 2 references for ABIN1098692

More Proteins for Heart and Neural Crest Derivatives Expressed 1 (HAND1) Interaction Partners

Human Heart and Neural Crest Derivatives Expressed 1 (HAND1) interaction partners

  1. Combined expression of NKX2-5 (show NKX2-5 Proteins), HAND1, and NOTCH1 (show NOTCH1 Proteins) coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome.

  2. These data show that miR (show MLXIP Proteins)-363 negatively regulates the expression of HAND1

  3. Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors.

  4. DNA methylation (show HELLS Proteins) status of NKX2-5 (show NKX2-5 Proteins), GATA4 (show GATA4 Proteins) and HAND1 in patients with tetralogy of fallot

  5. Increased methylation levels of HAND1 is associated with highly active Helicobacter pylori-related gastritis.

  6. This is the first report of mutations in the HAND1 gene in Chinese patients with VSD and provides new insight into the etiology of VSD

  7. Hand1 is dispensable for normal tyrosine hydroxylase (show TH Proteins) and dopamine beta-hydroxylase (show DBH Proteins) expression in sympathetic neurons, even when Hand2 (show HAND2 Proteins) gene dosage is concurrently reduced by half.

  8. Somatic mutations in NKX2-5 (show NKX2-5 Proteins), GATA4 (show GATA4 Proteins), and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart.

  9. Mutations or sequence variations in HAND1 or NKX2-5 (show NKX2-5 Proteins) genes may play role in etiology or pathogenesis of atrial isomerism.

  10. Our study shows no evidence of somatic NKX2-5 (show NKX2-5 Proteins), GATA4 (show GATA4 Proteins) and HAND1 mutations playing a role in the pathogenesis of Tetralogy of Fallot . Findings suggest that the GATA4 (show GATA4 Proteins) and HAND1 germline mutations are associated with non-syndromic congenital heart disease.

Xenopus laevis Heart and Neural Crest Derivatives Expressed 1 (HAND1) interaction partners

  1. increased vascular endothelial growth factor(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis

Mouse (Murine) Heart and Neural Crest Derivatives Expressed 1 (HAND1) interaction partners

  1. Hand1 is involved in proper osteogenesis of the bone collar via its control of Ihh (show IHH Proteins). Hand1 overexpression in the osteochondral progenitors caused defective prenatal diaphysis ossification. Hand1 inhibited Runx2 (show RUNX2 Proteins) transactivation of the Ihh (show IHH Proteins) proximal promoter.

  2. Re-expression of HAND1 in colon cancer cells induces terminal differentiation.

  3. Hand1 phosphoregulation in the distal arch neural crest has a critical role in craniofacial morphogenesis

  4. Suggest that prenatal alcohol exposure causes the over-expression of DHAND (show HAND2 Proteins) and EHAND by increasing H3K14ac in the fetal heart.

  5. Hand1 is part of a novel regulatory pathway linking cardiac oxygen levels with oxygen consumption.

  6. that Hand1 homodimer plays a dominant role during development and its expression dosage is critical for survival, whereas Hand1 heterodimers can be either dispensable or play a regulatory role to modulate the activity of Hand1 homodimer in vivo.

  7. Data suggest that stress-induced MAPK8 (show MAPK8 Proteins)/9 and PRKAA1 (show PRKAA1 Proteins)/2 regulate transcription factors Eomes (show EOMES Proteins)/HAND1 and ID2, respectively. Together this network mediates induction of CSH1 (show PRL3D1 Proteins) by stress.

  8. Hand1-mediated activation of Tbeta4 is essential for yolk sac (show ADCY10 Proteins) vasculogenesis and embryonic survival, and administration of synthetic TB4 partially rescues yolk sac (show ADCY10 Proteins) capillary plexus formation in Hand1-null embryos.

  9. Data define a critical threshold of Hand1 expression that is necessary for embryonic survival.

  10. Results show that Hand1 regulates development of lateral mesoderm derivatives and its loss in extraembryonic mesoderm is the primary cause of lethality in Hand1-null embryos.

HAND1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.

Gene names and symbols associated with HAND1

  • heart and neural crest derivatives expressed 1 (HAND1)
  • heart and neural crest derivatives expressed 1 (hand1)
  • eHAND basic helix-loop-helix transcription factor (EHAND)
  • heart and neural crest derivatives expressed 1 (Hand1)
  • heart and neural crest derivatives expressed transcript 1 (Hand1)
  • bHLHa27 protein
  • eHAND protein
  • Ehand1 protein
  • hand-1 protein
  • Hand1 protein
  • hand1-A protein
  • HXT protein
  • Th1 protein
  • Thing1 protein

Protein level used designations for HAND1

heart- and neural crest derivatives-expressed protein 1 , heart and neural crest derivatives expressed 1 , basic helix-loop-helix transcription factor HAND1 , eHAND basic helix-loop-helix transcription factor , Heart- and neural crest derivatives-expressed protein 1 , class A basic helix-loop-helix protein 27 , extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 , heart and neural crest derivatives expressed transcript 1 , heart and neural crest derivatives-expressed protein 1 , eHAND , helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast , thing-1

GENE ID SPECIES
489164 Canis lupus familiaris
541594 Sus scrofa
462209 Pan troglodytes
549497 Xenopus (Silurana) tropicalis
714450 Macaca mulatta
100009575 Oryctolagus cuniculus
9421 Homo sapiens
59112 Rattus norvegicus
517952 Bos taurus
395812 Gallus gallus
443353 Ovis aries
373663 Xenopus laevis
15110 Mus musculus
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