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Heart and Neural Crest Derivatives Expressed 2 (HAND2) ELISA Kits

The protein encoded by HAND2 belongs to the basic helix-loop-helix family of transcription factors. Additionally we are shipping Heart and Neural Crest Derivatives Expressed 2 Antibodies (94) and Heart and Neural Crest Derivatives Expressed 2 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HAND2 9464 P61296
HAND2 64637 P61295
HAND2 15111 Q61039
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Human 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
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More ELISA Kits for Heart and Neural Crest Derivatives Expressed 2 Interaction Partners

Human Heart and Neural Crest Derivatives Expressed 2 (HAND2) interaction partners

  1. HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha (show ESR1 ELISA Kits).

  2. suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human endometrial stromal cells.

  3. Reduced protein expression of HAND2 in the myenteric plexus of the aganglionic segment would suggest that HAND2 was involved in the pathogenesis of Hirschsprung disease.

  4. Increased HAND2 methylation was a feature of premalignant endometrial lesions and was seen to parallel a decrease in RNA and protein levels.

  5. Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q.

  6. No evidence of linkage between HAND2 and CL/P was obtained. Levelss of exclusion were obtained with different inheritance models. results did not support HAND2 in CL/P

  7. Expression analyses on both Hand2 conditionally null and hypomorphic backgrounds demonstrate that Hand2 is required for reporter activation in a gene dosage-dependent manner during sympathetic neurogenesis.

  8. Data suggest Hand2 plays an important role in decidualization; expression of Hand2 is significantly increased in response to prostaglandin E2.

  9. These data suggest that cytokines can inhibit norepinephrine transporter (show SLC6A2 ELISA Kits) expression through downregulation of Hand2 or Gata3 (show GATA3 ELISA Kits) in cultured sympathetic neurons, but axotomy in adult animals selectively suppresses Hand2 expression.

  10. Hand2 performs an essential role during transgenic epicardialization, directly impacting epicardial cell differentiation and formation of the coronary vasculature.

Zebrafish Heart and Neural Crest Derivatives Expressed 2 (HAND2) interaction partners

  1. hand2 can drive cardiomyocyte production in multiple contexts and through multiple mechanisms

  2. These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.

  3. Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.

  4. reduction of fn1 (show FN1 ELISA Kits) function enables rescue of cardiac fusion in hand2 mutants

  5. the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches

  6. Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM (show MMRN1 ELISA Kits) remodeling during organogenesis

  7. Hand2-endothelin 1 (show EDN1 ELISA Kits) effector, patterns ventral pharyngeal cartilage

  8. Hand2 is uniquely required for myocardial polarization.

  9. These results demonstrate in vivo an essential and selective function of hand2 for the noradrenergic differentiation of sympathetic neurons, and implicates tfap2a (show TFAP2A ELISA Kits) and gata2 as downstream effectors.

  10. Han is required in surrounding tissue, and not in a cell-autonomous manner, for thyroid development.

Mouse (Murine) Heart and Neural Crest Derivatives Expressed 2 (HAND2) interaction partners

  1. endocardial Hand2 is an integral downstream component of a Notch (show NOTCH1 ELISA Kits) endocardium-to-myocardium signaling pathway and a direct transcriptional regulator of Neuregulin1.

  2. analysis uncovers the transcriptional circuits that function in establishing distinct mesenchymal compartments downstream of HAND2 and upstream of SHH (show SHH ELISA Kits) signaling

  3. Suggest that prenatal alcohol exposure causes the over-expression of DHAND and EHAND (show HAND1 ELISA Kits) by increasing H3K14ac in the fetal heart.

  4. Hand2 loss-of-function dramatically reduces expression of Dopamine Beta Hydroxylase (Dbh (show DBH ELISA Kits)), a gene encoding a crucial catecholaminergic biosynthetic enzyme

  5. in vivo inhibition of miR (show MLXIP ELISA Kits)-25 by a specific antagomir evoked spontaneous cardiac dysfunction and sensitized the murine myocardium to heart failure in a Hand2-dependent manner

  6. overdosage of Hand2 is a major cause for the limb and heart defects phenotypes.

  7. Hand2 and NFATC physically interact on the DEGS1 promoter in the hypoxic mouse heart.

  8. Twist1 (show TWIST1 ELISA Kits), along with Hand2, is essential for the proximodistal patterning and development of the mandible and ossification.

  9. Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.

  10. Results suggest that Hand2 is essential for neurogenesis, neurotransmitter specification and neural network patterning in the developing enteric nervous system.

Heart and Neural Crest Derivatives Expressed 2 (HAND2) Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.

Gene names and symbols associated with HAND2

  • heart and neural crest derivatives expressed 2 (hand2-b) antibody
  • heart and neural crest derivatives expressed 2 (HAND2) antibody
  • heart and neural crest derivatives expressed 2 (hand2) antibody
  • heart and neural crest derivatives expressed 2 (LOC100218345) antibody
  • heart and neural crest derivatives expressed 2 (Hand2) antibody
  • heart and neural crest derivatives expressed 2 (hand2-a) antibody
  • heart and neural crest derivatives expressed transcript 2 (hand2) antibody
  • heart and neural crest derivatives expressed transcript 2 (Hand2) antibody
  • AI225906 antibody
  • AI661148 antibody
  • bHLHa26 antibody
  • dHAND antibody
  • DHAND2 antibody
  • Ehand2 antibody
  • hand2 antibody
  • Hand2' antibody
  • hand2-b antibody
  • Hed antibody
  • LOC100218345 antibody
  • Th2 antibody
  • Thing2 antibody
  • xhand2 antibody
  • zdHAND antibody
  • zgc:103415 antibody

Protein level used designations for HAND2

heart and neural crest derivatives expressed 2 , basic helix-loop-helix transcription factor HAND2 , class A basic helix-loop-helix protein 26 , deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 , heart- and neural crest derivatives-expressed protein 2 , dHand protein , heart and neural crest derivatives expressed transcript 2 , han , hands off , helix-loop-helix transcription factor expressed in embryo and deciduum , thing-2

GENE ID SPECIES
373833 Xenopus laevis
741581 Pan troglodytes
100101704 Xenopus (Silurana) tropicalis
100218345 Taeniopygia guttata
9464 Homo sapiens
64637 Rattus norvegicus
395813 Gallus gallus
607431 Canis lupus familiaris
781874 Bos taurus
373641 Xenopus laevis
58150 Danio rerio
15111 Mus musculus
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