Heat Shock 22kDa Protein 8 Proteins (HSPB8)

The protein encoded by HSPB8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. Additionally we are shipping Heat Shock 22kDa Protein 8 Antibodies (153) and Heat Shock 22kDa Protein 8 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSPB8 26353 Q9UJY1
HSPB8 80888 Q9JK92
HSPB8 113906 Q9EPX0
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Top Heat Shock 22kDa Protein 8 Proteins at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Macaca mulatta His tag   1 mg Log in to see 60 to 71 Days
$2,469.50
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,473.17
Details
Yeast Dog His tag   1 mg Log in to see 60 to 71 Days
$2,473.17
Details

HSPB8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced Heat Shock 22kDa Protein 8 Proteins

  1. Human HSPB8 Protein expressed in Escherichia coli (E. coli) - ABIN667769 : Benndorf, Sun, Gilmont, Biederman, Molloy, Goodmurphy, Cheng, Andrews, Welsh: HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27). in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for 667769

More Proteins for Heat Shock 22kDa Protein 8 (HSPB8) Interaction Partners

Human Heat Shock 22kDa Protein 8 (HSPB8) interaction partners

  1. It has been demonstrated that HSPB8-BAG3 (show BAG3 Proteins)-HSP70 (show HSP70 Proteins) ensures the functionality of stress granules and restores proteostasis by targeting defective ribosomal products for degradation.

  2. We report that overexpression of HSPB8 in immortalized motor neurones decreased the accumulation of TDP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 (show TARDBP Proteins) was observed for HSPB8 in Drosophila melanogaster Overexpression of HSP67Bc, the functional ortholog of human HSPB8, suppressed the eye degeneration caused by the cytoplasmic accumulation of a TDP-43 (show TARDBP Proteins) variant

  3. HSPB8 counteracts accumulation of aberrantly localized misfolded forms of TDP-43 (show TARDBP Proteins) and its 25 KDa fragment involved in most sporadic cases of Amyotrophic Lateral Sclerosis and of Fronto Lateral Temporal Dementia.

  4. expands the understanding of disease mechanisms, tissue involvement, and phenotypic outcome of HSPB8 mutations

  5. our findings suggest the existence of a so-far unrecognized quality control mechanism involving BAG3 (show BAG3 Proteins), HSPB8 and p62/SQSTM1 (show SQSTM1 Proteins) for accurate remodelling of actin-based mitotic structures that guide spindle orientation.

  6. This study demonstreated that expression of HSPB8 was restricted to GFAP (show GFAP Proteins)+ astrocytes in patient with multiple sclerosis.

  7. Pangenomic profiling of velcade-sensitive and resistant cells showed that the small heat shock protein HSPB8 was overexpressed in multiple myeloma resistant cells.

  8. HSP22 acts as a positive regulator in TGF-alpha (show TGFA Proteins)-induced migration of ovarian cancer cells, subsequently directing ovarian cancer toward progression.

  9. HSP22 plays an important role on gastric tumor aggressiveness and prognosis and may act as a promising target for prognostic prediction.

  10. Mutant HSPB8 causes protein aggregates and a reduced mitochondrial membrane potential in dermal fibroblasts from distal hereditary motor neuropathy patients.

Cow (Bovine) Heat Shock 22kDa Protein 8 (HSPB8) interaction partners

  1. GA genotype of SNP g.507G>A of HSPB8 gene has a probable role in heat tolerance in Sahiwal cattle.

Mouse (Murine) Heat Shock 22kDa Protein 8 (HSPB8) interaction partners

  1. Results revealed that the apoptosis-suppressing effect of heat shock protein B8 was mediated by the PI3K/Akt (show AKT1 Proteins) pathway in an in vitro model of ischemia.

  2. Increased Hsp20 (show HSPB6 Proteins) expression protects against OGDR-induced Golgi fragmentation and apoptosis, likely through interaction with Bax (show BAX Proteins) and subsequent amelioration of the OGDR-induced elevation in p115 cleavage via the Fas (show FAS Proteins)/FasL (show FASL Proteins) signaling pathway.

  3. Translocation of both Hsp22 and iNOS to the mitochondria is necessary for Hsp22-mediated stimulation of oxidative phosphorylation

  4. analysis of the phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse

  5. The results of this study strongly suggested that Hspb8 and its alpha-crystallin domain might act as pleiotropic prosurvival factor in the adult hippocampus.

  6. Hspb8 mRNA is constitutively expressed in specific brain structures across ontogeny; eventually these structures could be affected by the malfunction or deregulation of the Hspb8 molecule.

  7. Hsp22 represents a previously undescribed activator of both nuclear and mitochondrial functions of STAT3 (show STAT3 Proteins), and its deletion in the context of pressure overload in vivo accelerates the transition into heart failure and increases mortality.

  8. HspB8 increases misfolded SOD1 (show SOD1 Proteins) clearance via autophagy.

  9. Findings show that despite the ubiquitous presence of HSPB8, only motor neurons appear to be affected by the K141N and K141E mutations.

  10. H11 kinase promotes the synthesis of glycogen (show GYS1 Proteins), an essential fuel for the stressed heart in both conditions of overload and ischemia

Heat Shock 22kDa Protein 8 (HSPB8) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Gene names and symbols associated with HSPB8

  • heat shock 22kDa protein 8 (hspb8)
  • heat shock 22kDa protein 8 (HSPB8)
  • heat shock 22kDa protein 8 (LOC100349029)
  • heat shock protein, alpha-crystallin-related, b8 (hspb8)
  • heat shock protein 8 (Hspb8)
  • heat shock protein B8 (Hspb8)
  • AU018630 protein
  • AW413033 protein
  • CMT2L protein
  • Cryac protein
  • D5Ucla4 protein
  • DHMN2 protein
  • E2IG1 protein
  • fc09c11 protein
  • H11 protein
  • H11K protein
  • HMN2 protein
  • HMN2A protein
  • HSP20-like protein
  • Hsp22 protein
  • MGC64408 protein
  • wu:fc04b04 protein
  • wu:fc09c11 protein
  • zgc:64202 protein

Protein level used designations for HSPB8

heat shock 22kDa protein 8 , heat shock 27kDa protein 8 , heat shock protein beta-8 , E2-induced gene 1 protein , alpha-crystallin C chain , protein kinase H11 , small stress protein-like protein HSP22 , H11 kinase , crystallin, alpha C , heat shock protein 20-like protein , heat shock protein 8

GENE ID SPECIES
379472 Xenopus laevis
416988 Gallus gallus
452295 Pan troglodytes
100174469 Pongo abelii
100349029 Oryctolagus cuniculus
791580 Danio rerio
26353 Homo sapiens
403553 Canis lupus familiaris
539524 Bos taurus
574341 Macaca mulatta
80888 Mus musculus
113906 Rattus norvegicus
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