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The protein encoded by HSPA5 is a member of the heat shock protein 70 (HSP70) family. Additionally we are shipping GRP78 Kits (34) and GRP78 Proteins (23) and many more products for this protein.
Showing 10 out of 389 products:
Dog (Canine) Polyclonal GRP78 Primary Antibody for ICC, IF - ABIN863190
Cho, Park, Kim, Kim, Kim, Jang: BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1. in Molecular and cellular biology 2006
Show all 9 references for ABIN863190
Cow (Bovine) Monoclonal GRP78 Primary Antibody for ELISA, WB - ABIN863113
Yang, Turner, Gaut: The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. in The Journal of biological chemistry 1998
Show all 6 references for ABIN863113
Cow (Bovine) Monoclonal GRP78 Primary Antibody for ICC, IF - ABIN863112
Koomägi, Mattern, Volm: Glucose-related protein (GRP78) and its relationship to the drug-resistance proteins P170, GST-pi, LRP56 and angiogenesis in non-small cell lung carcinomas. in Anticancer research 2000
Show all 6 references for ABIN863112
Human Polyclonal GRP78 Primary Antibody for EIA, IHC (p) - ABIN356850
Sargent, Dunham, Trowsdale, Campbell: Human major histocompatibility complex contains genes for the major heat shock protein HSP70. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Monoclonal GRP78 Primary Antibody for IHC, ELISA - ABIN969204
Honda, Horie, Daito, Ikuta, Tomonaga: Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface. in Journal of virology 2009
Show all 4 references for ABIN969204
Mouse (Murine) Monoclonal GRP78 Primary Antibody for Func, EIA - ABIN371046
Bole, Hendershot, Kearney: Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas. in The Journal of cell biology 1986
Show all 3 references for ABIN371046
Human Polyclonal GRP78 Primary Antibody for IF, IHC (p) - ABIN651232
Zhao, Zhang, Tian, Fang, Lu, Yuan, Yang, Wen: Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis. in Journal of medical virology 2009
Show all 2 references for ABIN651232
Human Polyclonal GRP78 Primary Antibody for IF (cc), IF (p) - ABIN673554
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
Show all 2 references for ABIN673554
Human Polyclonal GRP78 Primary Antibody for FACS, IHC (p) - ABIN651231
Zhuang, Scolyer, Murali, McCarthy, Zhang, Thompson, Hersey: Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010
Show all 2 references for ABIN651231
Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.
we report that GRP78 plays a crucial role in protecting renal cell carcinoma (show MOK Antibodies) cells from hypoxic and hypoglycemic stress induced by anti-angiogenic therapy
results provide new mechanistic insights into the understanding that deacetylation of HSPA5 by HDAC6 (show HDAC6 Antibodies) facilitates GP78 (show AMFR Antibodies)-mediated HSPA5 ubiquitination
Data show that molecular chaperone (show HSP90AA1 Antibodies) GRP78 and survivin (show BIRC5 Antibodies) cooperatively conferred multi-drug resistance (MDR) by decreasing folate deficiency (FD)-induced reactive oxygen species (ROS (show ROS1 Antibodies)) generation.
GRP78 phosphorylation in sperm undergoes spatial reorganization during epididymal maturation.
The protein chaperone GRP78 and the unfolded protein response were implicated as drivers of drug resistance. Preclinical studies show inhibiting GRP78 can reverse drug resistance. [review]
stabilization of WASF3 (show WASF3 Antibodies) function occurs through its interaction with ATAD3A (show ATAD3A Antibodies) and GRP78, which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles
The biological interaction of amelogenin (show AMELX Antibodies) with Grp78 offers significant therapeutic potential for understanding the biological components and specific functions involved in the signal transduction of amelogenin (show AMELX Antibodies)-induced periodontal tissue regeneration.
STAT3 (show STAT3 Antibodies) mediates GRP78-promoted breast cancer cell growth and migration.
Inhibition of GRP78 functional activity disrupts autophagy and enhances the anti-myeloma effect of bortezomib.
Study suggested that the GRP78 rs391957 promoter polymorphism is a potential risk factor for type 2 diabetic peripheral neuropathy
This paper reports the localization of both GRP78 and HSP60 (show HSPD1 Antibodies) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (show HSPD1 Antibodies) in the sperm midpiece.
BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death
We show that chronic VPA treatment did not modify the ATXN3 (show ATXN3 Antibodies) inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects
these findings reveal a novel critical role of GRP78 in regulating ER stress-mediated apoptosis in cartilage development and the molecular mechanisms involved.
ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src (show SRC Antibodies) activation as well as induction of apoptosis
BIP increased surface CD19 molecule (show CD19 Antibodies) expression intensity and IL-10 (show IL10 Antibodies)(+), PD-L1 (show CD274 Antibodies)(hi) and FasL (show FASL Antibodies)(hi) B cells induced by BIP share the CD19 (show CD19 Antibodies)(hi) phenotype
These studies demonstrate that BiP is critical for myelinating cell survival and contributes to the protective response of oligodendrocyte against inflammatory demyelination.
These studies imply GRP78, but not GRP94 (show HSP90B1 Antibodies), is required for mammary gland development.
The expression of GRP78 and Bcl-2 (show BCL2 Antibodies) was significantly higher in astrocytes pretreated with recombinant Shh (show SHH Antibodies). These findings suggest that the expression of Shh (show SHH Antibodies) may inhibit cell death by activating Bcl-2 (show BCL2 Antibodies) through a GRP78-dependent pathway.
A highly specific monoclonal antibody against GRP78 suppressed AKT (show AKT1 Antibodies) activation and increased apoptosis in the cPten(f/f) tumors.
AdGRP78 reduced expression of lipogenic genes and plasma triglycerides in the db/db (show LEPR Antibodies) strain. Both G5 and G8 protein levels increased as did total biliary cholesterol
Heterozygous mutant BiP mice revealed motor disabilities in aging.
Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.
78 kDa glucose-regulated protein
, heat shock 70 kDa protein 5
, Protein 1603
, 78 kDa glucose-regulated protein homolog
, luminal-binding protein
, glucose-regulated protein 78
, glucose-regulated protein 78kDa
, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
, GRP 78
, heavy-chain binding protein BiP
, immunoglobulin heavy chain-binding protein
, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
, glucose-regulated protein, 78kDa
, XAP-1 antigen
, glucose regulated protein, 78 kDa
, heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
, heat shock 70kD protein 5
, heat shock 70kDa protein 5 (glucose-regulated protein)
, steroidogenesis-activator polypeptide