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anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) Antibodies

The protein encoded by HSPA5 is a member of the heat shock protein 70 (HSP70) family. Additionally we are shipping GRP78 Kits (34) and GRP78 Proteins (23) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HSPA5 3309 P11021
HSPA5 14828 P20029
HSPA5 25617 P06761
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Top anti-GRP78 Antibodies at antibodies-online.com

Showing 10 out of 464 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB HSPA5 Antibody (C-term) (ABIN651231) western blot analysis in A375,A2058,Hela cell line lysates (35 µg/lane). This demonstrates the HSPA5 antibody detected the HSPA5 protein (arrow). HSPA5 Antibody (C-term) (ABIN651231) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB HSPA5 Antibody (Center) (ABIN651232) western blot analysis in Hela,A2058,NCI-H460 cell line lysates (35 µg/lane). This demonstrates the HSPA5 antibody detected the HSPA5 protein (arrow). HSPA5 Antibody (Center) (ABIN651232) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), SimWes, WB Figure 1 shows a Western blot of GRP78 on indicated cell extracts using ABIN152679. Simple Western: GRP78/HSPA5 Antibody [ABIN152679] - Simple Western lane view shows a specific band for GRP78 in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230kDa separation system. 0.1 mL Log in to see 5 to 7 Days
$408.19
Details
Chicken Rabbit Un-conjugated FACS, ICC, IF, SimWes, WB Western Blot: GRP78/HSPA5 Antibody [NBP1-06274] - Detection of Bip/Grp78 on HeLa whole cell extracts using NBP1-06274. 0.1 mL Log in to see 5 to 7 Days
$473.81
Details
Cow Mouse Un-conjugated ICC, IF, WB Grp78 human recom copy_1. 100 μg Log in to see 3 to 4 Days
$349.80
Details
Cow Mouse Un-conjugated ELISA, WB Grp78 human recom copy. 100 μg Log in to see 3 to 4 Days
$349.80
Details
Dog Rabbit Un-conjugated ICC, IF, IHC, ELISA, WB Glia GD lysate Western Blotting 1 in 1000 copy. 100 μg Log in to see 3 to 4 Days
$355.30
Details
Human Mouse Un-conjugated IHC, ELISA, WB Figure 1: Immunohistochemical analysis of paraffin-embedded human Thyroid tissues using HSPA5 mouse mAb Figure 2: Western blot analysis using HSPA5 mouse mAb against NIH/3T3 (1), Hela (2) and Jurkat (3) cell lysate. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Mouse Rat Biotin Func, EIA, WB 0.5 mg Log in to see 6 to 8 Days
$445.50
Details

HSPA5 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-GRP78 Antibodies

  1. Chicken Polyclonal GRP78 Primary Antibody for FACS, ICC - ABIN446401 : Pepping, Freeman, Gupta, Keller, Bruce-Keller: NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. in American journal of physiology. Endocrinology and metabolism 2013 (PubMed)
    Show all 11 references for ABIN446401

  2. Dog (Canine) Polyclonal GRP78 Primary Antibody for ICC, IF - ABIN863190 : Cho, Park, Kim, Kim, Kim, Jang: BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1. in Molecular and cellular biology 2006 (PubMed)
    Show all 9 references for ABIN863190

  3. Cow (Bovine) Monoclonal GRP78 Primary Antibody for ELISA, WB - ABIN863113 : Yang, Turner, Gaut: The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. in The Journal of biological chemistry 1998 (PubMed)
    Show all 6 references for ABIN863113

  4. Cow (Bovine) Monoclonal GRP78 Primary Antibody for ICC, IF - ABIN863112 : Koomägi, Mattern, Volm: Glucose-related protein (GRP78) and its relationship to the drug-resistance proteins P170, GST-pi, LRP56 and angiogenesis in non-small cell lung carcinomas. in Anticancer research 2000 (PubMed)
    Show all 6 references for ABIN863112

  5. Human Polyclonal GRP78 Primary Antibody for EIA, IHC (p) - ABIN356850 : Sargent, Dunham, Trowsdale, Campbell: Human major histocompatibility complex contains genes for the major heat shock protein HSP70. in Proceedings of the National Academy of Sciences of the United States of America 1989 (PubMed)
    Show all 5 references for ABIN356850

  6. Human Monoclonal GRP78 Primary Antibody for IHC, ELISA - ABIN969204 : Honda, Horie, Daito, Ikuta, Tomonaga: Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface. in Journal of virology 2009 (PubMed)
    Show all 4 references for ABIN969204

  7. Human Polyclonal GRP78 Primary Antibody for ICC, IF - ABIN152679 : Shin, Feltri, Wrabetz: Altered Trafficking and Processing of GALC Mutants Correlates with Globoid Cell Leukodystrophy Severity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 (PubMed)
    Show all 4 references for ABIN152679

  8. Human Polyclonal GRP78 Primary Antibody for IF, IHC (p) - ABIN651232 : Zhao, Zhang, Tian, Fang, Lu, Yuan, Yang, Wen: Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis. in Journal of medical virology 2009 (PubMed)
    Show all 2 references for ABIN651232

  9. Human Polyclonal GRP78 Primary Antibody for FACS, IHC (p) - ABIN651231 : Zhuang, Scolyer, Murali, McCarthy, Zhang, Thompson, Hersey: Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010 (PubMed)
    Show all 2 references for ABIN651231

  10. Human Polyclonal GRP78 Primary Antibody for IF (cc), IF (p) - ABIN673554 : Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010 (PubMed)
    Show all 2 references for ABIN673554

More Antibodies against GRP78 Interaction Partners

Xenopus laevis Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.

Human Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. The measurement of the GRP78 level associated with the determination of intraperitoneal fat can be a useful predictor for endometrial cancer.

  2. Prion protein (show PRNP Antibodies) mutants inhibit Hrd1 (show SYVN1 Antibodies)-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP (show GDF10 Antibodies).

  3. Data revealed that Enterovirus 71 infection might cause upregulation and aberrant redistribution of GRP78/BiP to the cytosol, thereby facilitating virus replication.

  4. Data show that bortezomib/CX-4945 combination modulates endoplasmic reticulum (ER) stress/unfolded protein response (UPR) signaling by down-regulation BIP/Grp78 and activates NF-kappa B (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) pro-apoptotic functions.

  5. Data suggest that molecular chaperone (show HSP90AA1 Antibodies) GRP78 contributes to toll-like receptor-3 (TLR3 (show TLR3 Antibodies))-mediated, interferon regulatory factor 3 (show IRF3 Antibodies) protein (IRF3 (show IRF3 Antibodies))-dependent innate immune response to hepatitis C virus (HCV) in hepatocytes.

  6. This work demonstrates that alpha2M*/CS-GRP78 acts as an upstream regulator of the PDK1 (show PDK1 Antibodies)/PLK1 (show PLK1 Antibodies) signaling axis to modulate c-MYC (show MYC Antibodies) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (show MYC Antibodies)-associated malignant progression.

  7. The present data suggest that GRP78 plays a crucial role in the proliferation, migration, and invasion of pancreatic cancer cells and may be a suitable prognostic marker in pancreatic ductal adenocarcinoma.

  8. we report that GRP78 plays a crucial role in protecting renal cell carcinoma (show MOK Antibodies) cells from hypoxic and hypoglycemic stress induced by anti-angiogenic therapy

  9. results provide new mechanistic insights into the understanding that deacetylation of HSPA5 by HDAC6 (show HDAC6 Antibodies) facilitates GP78 (show AMFR Antibodies)-mediated HSPA5 ubiquitination

  10. Data show that molecular chaperone (show HSP90AA1 Antibodies) GRP78 and survivin (show BIRC5 Antibodies) cooperatively conferred multi-drug resistance (MDR) by decreasing folate deficiency (FD)-induced reactive oxygen species (ROS (show ROS1 Antibodies)) generation.

Cow (Bovine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. This paper reports the localization of both GRP78 and HSP60 (show HSPD1 Antibodies) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (show HSPD1 Antibodies) in the sperm midpiece.

  2. BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death

Pig (Porcine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Over-expression of GRP78 enhances replication of Porcine Circovirus 2.

Mouse (Murine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. data show that Med inhibits ER stress-induced apoptosis and promotes osteoblast cell survival by targeting GRP78.

  2. These results suggested the important roles of endoplasmic reticulum-related chaperons, Bip and SIL1 (show SIL1 Antibodies), in Alzheimer's disease-like tau hyperphosphorylation.

  3. We show that chronic VPA treatment did not modify the ATXN3 (show ATXN3 Antibodies) inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects

  4. these findings reveal a novel critical role of GRP78 in regulating ER stress-mediated apoptosis in cartilage development and the molecular mechanisms involved.

  5. ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src (show SRC Antibodies) activation as well as induction of apoptosis

  6. BIP increased surface CD19 molecule (show CD19 Antibodies) expression intensity and IL-10 (show IL10 Antibodies)(+), PD-L1 (show CD274 Antibodies)(hi) and FasL (show FASL Antibodies)(hi) B cells induced by BIP share the CD19 (show CD19 Antibodies)(hi) phenotype

  7. These studies demonstrate that BiP is critical for myelinating cell survival and contributes to the protective response of oligodendrocyte against inflammatory demyelination.

  8. These studies imply GRP78, but not GRP94 (show HSP90B1 Antibodies), is required for mammary gland development.

  9. The expression of GRP78 and Bcl-2 (show BCL2 Antibodies) was significantly higher in astrocytes pretreated with recombinant Shh (show SHH Antibodies). These findings suggest that the expression of Shh (show SHH Antibodies) may inhibit cell death by activating Bcl-2 (show BCL2 Antibodies) through a GRP78-dependent pathway.

  10. A highly specific monoclonal antibody against GRP78 suppressed AKT (show AKT1 Antibodies) activation and increased apoptosis in the cPten(f/f) tumors.

Zebrafish Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.

GRP78 (HSPA5) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.

Gene names and symbols associated with HSPA5

  • 78 kDa glucose-regulated protein (CpipJ_CPIJ003550) antibody
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5) antibody
  • 78 kDa glucose-regulated protein (grp78) antibody
  • BiP/GRP78 (LOC100533358) antibody
  • glucose-regulated protein 78 (BiP/grp78) antibody
  • glucose-regulated protein 78 (Tc00.1047053506585.40) antibody
  • glucose-regulated protein 78 (Tb11.02.5450) antibody
  • glucose-regulated protein 78 (Tb11.02.5500) antibody
  • glucose-regulated protein 78 (LmjF28.1200) antibody
  • Hsp70 family ATPase KAR2 (KAR2) antibody
  • glucose-regulated protein 78kDa (grp78) antibody
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (hspa5) antibody
  • heat shock 70 kDa protein 5a (hspa5) antibody
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (Hspa5) antibody
  • heat shock protein 5 (Hspa5) antibody
  • heat shock protein 5 (hspa5) antibody
  • AL022860 antibody
  • AU019543 antibody
  • baffled antibody
  • Bip antibody
  • cb865 antibody
  • D2Wsu17e antibody
  • D2Wsu141e antibody
  • fb60h09 antibody
  • fi36d04 antibody
  • GRP-78 antibody
  • Grp78 antibody
  • Hsce70 antibody
  • hspa5a antibody
  • mBiP antibody
  • MIF2 antibody
  • SEZ-7 antibody
  • Sez7 antibody
  • wu:fb60h09 antibody
  • wu:fi36d04 antibody
  • zgc:55994 antibody
  • zgc:77606 antibody

Protein level used designations for HSPA5

78 kDa glucose-regulated protein , GRP-78 , heat shock 70 kDa protein 5 , Protein 1603 , 78 kDa glucose-regulated protein homolog , luminal-binding protein , glucose-regulated protein 78 , glucose-regulated protein 78kDa , heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) , GRP 78 , biP , heavy-chain binding protein BiP , immunoglobulin heavy chain-binding protein , endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 , glucose-regulated protein, 78kDa , XAP-1 antigen , glucose regulated protein, 78 kDa , heat shock 70kD protein 5 (glucose-regulated protein, 78kD) , heat shock 70kD protein 5 , heat shock 70kDa protein 5 (glucose-regulated protein) , steroidogenesis-activator polypeptide , bip

GENE ID SPECIES
6034961 Culex quinquefasciatus
100173944 Pongo abelii
100196613 Salmo salar
100533358 Aplysia californica
543957 Solanum lycopersicum
3540481 Trypanosoma cruzi strain CL Brener
3665880 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3665885 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5653331 Leishmania major strain Friedlin
853418 Saccharomyces cerevisiae S288c
100135840 Oncorhynchus mykiss
379756 Xenopus laevis
464733 Pan troglodytes
703193 Macaca mulatta
100015941 Monodelphis domestica
100599238 Nomascus leucogenys
397850 Xenopus laevis
3309 Homo sapiens
415113 Bos taurus
396487 Gallus gallus
100731108 Cavia porcellus
407060 Sus scrofa
480726 Canis lupus familiaris
780447 Ovis aries
14828 Mus musculus
25617 Rattus norvegicus
378848 Danio rerio
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