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The protein encoded by HSPA5 is a member of the heat shock protein 70 (HSP70) family. Additionally we are shipping GRP78 Kits (34) and GRP78 Proteins (23) and many more products for this protein.
Showing 10 out of 464 products:
Chicken Polyclonal GRP78 Primary Antibody for FACS, ICC - ABIN446401
Pepping, Freeman, Gupta, Keller, Bruce-Keller: NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. in American journal of physiology. Endocrinology and metabolism 2013
Show all 11 references for ABIN446401
Dog (Canine) Polyclonal GRP78 Primary Antibody for ICC, IF - ABIN863190
Cho, Park, Kim, Kim, Kim, Jang: BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1. in Molecular and cellular biology 2006
Show all 9 references for ABIN863190
Cow (Bovine) Monoclonal GRP78 Primary Antibody for ELISA, WB - ABIN863113
Yang, Turner, Gaut: The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. in The Journal of biological chemistry 1998
Show all 6 references for ABIN863113
Cow (Bovine) Monoclonal GRP78 Primary Antibody for ICC, IF - ABIN863112
Koomägi, Mattern, Volm: Glucose-related protein (GRP78) and its relationship to the drug-resistance proteins P170, GST-pi, LRP56 and angiogenesis in non-small cell lung carcinomas. in Anticancer research 2000
Show all 6 references for ABIN863112
Human Polyclonal GRP78 Primary Antibody for EIA, IHC (p) - ABIN356850
Sargent, Dunham, Trowsdale, Campbell: Human major histocompatibility complex contains genes for the major heat shock protein HSP70. in Proceedings of the National Academy of Sciences of the United States of America 1989
Show all 5 references for ABIN356850
Human Monoclonal GRP78 Primary Antibody for IHC, ELISA - ABIN969204
Honda, Horie, Daito, Ikuta, Tomonaga: Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface. in Journal of virology 2009
Show all 4 references for ABIN969204
Human Polyclonal GRP78 Primary Antibody for ICC, IF - ABIN152679
Shin, Feltri, Wrabetz: Altered Trafficking and Processing of GALC Mutants Correlates with Globoid Cell Leukodystrophy Severity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Show all 4 references for ABIN152679
Human Polyclonal GRP78 Primary Antibody for IF, IHC (p) - ABIN651232
Zhao, Zhang, Tian, Fang, Lu, Yuan, Yang, Wen: Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis. in Journal of medical virology 2009
Show all 2 references for ABIN651232
Human Polyclonal GRP78 Primary Antibody for FACS, IHC (p) - ABIN651231
Zhuang, Scolyer, Murali, McCarthy, Zhang, Thompson, Hersey: Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010
Show all 2 references for ABIN651231
Human Polyclonal GRP78 Primary Antibody for IF (cc), IF (p) - ABIN673554
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
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Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.
The measurement of the GRP78 level associated with the determination of intraperitoneal fat can be a useful predictor for endometrial cancer.
Prion protein (show PRNP Antibodies) mutants inhibit Hrd1 (show SYVN1 Antibodies)-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP (show GDF10 Antibodies).
Data revealed that Enterovirus 71 infection might cause upregulation and aberrant redistribution of GRP78/BiP to the cytosol, thereby facilitating virus replication.
Data show that bortezomib/CX-4945 combination modulates endoplasmic reticulum (ER) stress/unfolded protein response (UPR) signaling by down-regulation BIP/Grp78 and activates NF-kappa B (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) pro-apoptotic functions.
Data suggest that molecular chaperone (show HSP90AA1 Antibodies) GRP78 contributes to toll-like receptor-3 (TLR3 (show TLR3 Antibodies))-mediated, interferon regulatory factor 3 (show IRF3 Antibodies) protein (IRF3 (show IRF3 Antibodies))-dependent innate immune response to hepatitis C virus (HCV) in hepatocytes.
This work demonstrates that alpha2M*/CS-GRP78 acts as an upstream regulator of the PDK1 (show PDK1 Antibodies)/PLK1 (show PLK1 Antibodies) signaling axis to modulate c-MYC (show MYC Antibodies) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (show MYC Antibodies)-associated malignant progression.
The present data suggest that GRP78 plays a crucial role in the proliferation, migration, and invasion of pancreatic cancer cells and may be a suitable prognostic marker in pancreatic ductal adenocarcinoma.
we report that GRP78 plays a crucial role in protecting renal cell carcinoma (show MOK Antibodies) cells from hypoxic and hypoglycemic stress induced by anti-angiogenic therapy
results provide new mechanistic insights into the understanding that deacetylation of HSPA5 by HDAC6 (show HDAC6 Antibodies) facilitates GP78 (show AMFR Antibodies)-mediated HSPA5 ubiquitination
Data show that molecular chaperone (show HSP90AA1 Antibodies) GRP78 and survivin (show BIRC5 Antibodies) cooperatively conferred multi-drug resistance (MDR) by decreasing folate deficiency (FD)-induced reactive oxygen species (ROS (show ROS1 Antibodies)) generation.
This paper reports the localization of both GRP78 and HSP60 (show HSPD1 Antibodies) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (show HSPD1 Antibodies) in the sperm midpiece.
BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death
Over-expression of GRP78 enhances replication of Porcine Circovirus 2.
data show that Med inhibits ER stress-induced apoptosis and promotes osteoblast cell survival by targeting GRP78.
These results suggested the important roles of endoplasmic reticulum-related chaperons, Bip and SIL1 (show SIL1 Antibodies), in Alzheimer's disease-like tau hyperphosphorylation.
We show that chronic VPA treatment did not modify the ATXN3 (show ATXN3 Antibodies) inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects
these findings reveal a novel critical role of GRP78 in regulating ER stress-mediated apoptosis in cartilage development and the molecular mechanisms involved.
ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src (show SRC Antibodies) activation as well as induction of apoptosis
BIP increased surface CD19 molecule (show CD19 Antibodies) expression intensity and IL-10 (show IL10 Antibodies)(+), PD-L1 (show CD274 Antibodies)(hi) and FasL (show FASL Antibodies)(hi) B cells induced by BIP share the CD19 (show CD19 Antibodies)(hi) phenotype
These studies demonstrate that BiP is critical for myelinating cell survival and contributes to the protective response of oligodendrocyte against inflammatory demyelination.
These studies imply GRP78, but not GRP94 (show HSP90B1 Antibodies), is required for mammary gland development.
The expression of GRP78 and Bcl-2 (show BCL2 Antibodies) was significantly higher in astrocytes pretreated with recombinant Shh (show SHH Antibodies). These findings suggest that the expression of Shh (show SHH Antibodies) may inhibit cell death by activating Bcl-2 (show BCL2 Antibodies) through a GRP78-dependent pathway.
A highly specific monoclonal antibody against GRP78 suppressed AKT (show AKT1 Antibodies) activation and increased apoptosis in the cPten(f/f) tumors.
Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.
78 kDa glucose-regulated protein
, heat shock 70 kDa protein 5
, Protein 1603
, 78 kDa glucose-regulated protein homolog
, luminal-binding protein
, glucose-regulated protein 78
, glucose-regulated protein 78kDa
, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
, GRP 78
, heavy-chain binding protein BiP
, immunoglobulin heavy chain-binding protein
, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
, glucose-regulated protein, 78kDa
, XAP-1 antigen
, glucose regulated protein, 78 kDa
, heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
, heat shock 70kD protein 5
, heat shock 70kDa protein 5 (glucose-regulated protein)
, steroidogenesis-activator polypeptide