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HERC3 encodes a member the HERC ubiquitin ligase family. Additionally we are shipping and many more products for this protein.
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HERC3 negatively regulates NF-kappaB (show NFKB1 Antibodies) signaling by enhancing RelA (show NFkBP65 Antibodies) subunit degradation.
we found somatic mutations of HERC2 (show HERC2 Antibodies), HERC3, TRIP12 (show TRIP12 Antibodies), UBE2Q1 (show UBE2Q1 Antibodies) and UBE4B (show UBE4B Antibodies) genes in gastric carcinoma and colorectal carcinomas with microsatellite instability
Allele-specific polyadenylation occurs at the imprinted Herc3/Nap1l5 locus.
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
probable E3 ubiquitin-protein ligase HERC3
, hect domain and RLD 3
, Putative E3 ubiquitin-protein ligase HERC3
, probable E3 ubiquitin-protein ligase HERC3-like
, HECT domain and RCC1-like domain-containing protein 3