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Heparan Sulfate Proteoglycan 2 Proteins (HSPG2)

HSPG2 encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. Additionally we are shipping HSPG2 Antibodies (54) and HSPG2 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSPG2 3339 P98160
Rat HSPG2 HSPG2 117511  
HSPG2 15530 Q05793
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Top HSPG2 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$633.60
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$810.39
Details

HSPG2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Heparan Sulfate Proteoglycan 2 (HSPG2) Interaction Partners

Rabbit Heparan Sulfate Proteoglycan 2 (HSPG2) interaction partners

  1. Nidogen-1 (show NID1 Proteins) and nidogen-2 (show NID2 Proteins) mRNAs were highly expressed in keratocytes, whereas perlecan was highly expressed in myofibroblasts.

  2. RUS3108 is a novel perlecan-inducing compound which may prevent in-stent restenosis.

Human Heparan Sulfate Proteoglycan 2 (HSPG2) interaction partners

  1. Knockdown of agrin (show AGRN Proteins) and perlecan promoted a decrease on cell migration and adhesion, and on resistance of cells to cisplatin.

  2. As five of the seven missense mutations in Schwartz-Jampel syndrome affect domain III of perlecan, domain III is likely to be essential for secretion of perlecan into the extracellular space.

  3. Rare variants in the HSPG2 gene potentially contribute to the idiopathic scoliosis phenotype in a subset of patients with idiopathic scoliosis

  4. The perlecan is the primary ECM (show MMRN1 Proteins) molecule comprising intraepithelial stroma of the junctional epithelium, in which leukocytes may migrate on ECM (show MMRN1 Proteins) scaffolds in intercellular space toward the surface of the gingival sulci or pockets.

  5. We conclude that enzymatic processing of perlecan in the BM or territorial matrix by MMP-7 (show MMP7 Proteins) as occurs in the invasive tumor microenvironment acts as a molecular switch to alter PCa (show FLVCR1 Proteins) cell behavior and favor cell dispersion and invasiveness.

  6. Mutant genes (CELA1, HSPG2, and KCNK5) in Balkan endemic nephropathy patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis.

  7. this study hypothesizes the transcriptional control of the HSPG2 gene in mast cells to synthesize these transcripts supports their stimulatory and specific role in wound healing and tissue regeneration.

  8. Perlecan synthesized by smooth muscle cells differs from that synthesized by endothelial cells by possessing different signaling capabilities and thus differential modulation of cell adhesion, proliferation and growth factor signaling.

  9. role for perlecan in chondrogenic and osteogenic events which drive discal development and ossification of the vertebral bodies.

  10. Urinary perlecan laminin G-like 3 peptide and Ig kappa light chains were decreased in IgA nephropathy.

Cow (Bovine) Heparan Sulfate Proteoglycan 2 (HSPG2) interaction partners

  1. Blocking of perlecan by anti-perlecan antiserum inhibited the migration of vascular endothelial cells (VECs) and bone marrow-derived mesenchymal stem cells, and exogenous perlecan added to the culture medium promoted the migration of these cell types.

  2. RUS3108 is a novel perlecan-inducing compound which may prevent in-stent restenosis.

  3. Hyperglycemia-induced structural changes in perlecan may result in a subendothelial matrix that is more favorable to retention of monocytes. 2 forms of perlecan exist in BAEC SEM, 1 with HS chains only and 1 with both HS and CS/DS chains.

  4. results suggest that perlecan made by growth plate chondrocytes is a low affinity receptor for FGF-2 (show FGF2 Proteins) and acts to sequester FGF-2 (show FGF2 Proteins) away from the high affinity receptor

  5. data show that growth plate perlecan binds to FGF-2 (show FGF2 Proteins) by its heparan sulfate chains but can only deliver FGF-2 (show FGF2 Proteins) to FGF receptors when its chondroitin sulfate chains are removed.

Pig (Porcine) Heparan Sulfate Proteoglycan 2 (HSPG2) interaction partners

  1. Perlecan is a defining factor in both the biochemical and biomechanical properties of the pericellular matrix.

Mouse (Murine) Heparan Sulfate Proteoglycan 2 (HSPG2) interaction partners

  1. Hspg2 inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle.

  2. Perlecan HS has significant roles in directing the development of posttraumatic OA, potentially via the alteration of FGF/HS/FGFR (show FGFR2 Proteins) signaling.

  3. An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.

  4. LG3, through interactions with alpha2beta1 integrins on recipient-derived cells leading to activation of ERK1/2 and increased migration, favors myointimal thickening

  5. Perlecan binds the clustering molecule gliomedin (show GLDN Proteins) and enhances clustering of node of Ranvier components.

  6. perlecan deficiency alters cartilage matrix patterning and, as we now show, coordinately influences bone formation and calcification

  7. applied a fluorescent technique to older mice expressing or deficient for perlecan/HSPG2, a large heparan-sulfate proteoglycan normally secreted in osteocytic PCM (show PCMT1 Proteins)

  8. [review] Perlecan domain V is present acutely and chronically after ischemic stroke and could have a role in acute neuroprotection and chronic neurorepair at the site of stroke brain injury.

  9. Synovial perlecan plays an important role in osteophyte development in osteoarthritis.

  10. Perlecan supports the maintenance of brain and skin subendothelial basement membranes and promotes vasculo- and angiogenesis by modulating FGF-2 (show FGF2 Proteins) function

HSPG2 Protein Profile

Protein Summary

This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.

Gene names and symbols associated with HSPG2

  • heparan sulfate proteoglycan 2 (HSPG2)
  • heparan sulfate proteoglycan 2 (LOC100340334)
  • heparan sulfate proteoglycan 2 (hspg2)
  • heparan sulfate proteoglycan 2 (Hspg2)
  • perlecan (heparan sulfate proteoglycan 2) (Hspg2)
  • AI852380 protein
  • HSPG protein
  • HSPG2 protein
  • Pcn protein
  • per protein
  • Plc protein
  • PRCAN protein
  • SJA protein
  • SJS protein
  • SJS1 protein

Protein level used designations for HSPG2

heparan sulfate proteoglycan 2 , perlecan , basement membrane-specific heparan sulfate proteoglycan core protein-like , basement membrane-specific heparan sulfate proteoglycan core protein , endorepellin (domain V region) , perlecan proteoglycan , perlecan (heparan sulfate proteoglycan 2) , HSPG

GENE ID SPECIES
612371 Canis lupus familiaris
707213 Macaca mulatta
100071701 Equus caballus
100294588 Ovis aries
100340334 Oryctolagus cuniculus
100467831 Ailuropoda melanoleuca
100494785 Xenopus (Silurana) tropicalis
100617792 Monodelphis domestica
3339 Homo sapiens
403440 Canis lupus familiaris
444872 Bos taurus
100517288 Sus scrofa
117511 Rattus norvegicus
15530 Mus musculus
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