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HPSE2 encodes a heparanase enzyme. Additionally we are shipping and Heparanase 2 Kits (1) and many more products for this protein.
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study of tissue expression profiles, polymorphisms of HPSE (show HPSE Antibodies) and HPSE2 genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE (show HPSE Antibodies) mRNA was obviously upregulated, while HPSE2 mRNA did not induce a prominent change in PAMs
HPSE2 mutations were found in one Urofacial syndrome family but not detected in patients with non-neurogenic neurogenic bladder and severe lower urinary tract dysfunction
Heparanase 2 is more intensely expressed in the glandular tissue of cancer than in nonneoplastic endometrium; the HPSE2 expression in the stromal tissue is higher in the nonneoplastic controls compared with cancer mainly in the secretory endometrium.
High expression of heparanase-2 is associated significantly with gastric tumor growth and differentiation
Data indicate that the overexpression of HPSE1 (show HPSE Antibodies) and HPSE2 in the intervertebral degenerated discs suggests a role for these factors in mediating extracellular matrix remodeling in degenerative discs during disease development.
HPSE2 c.631T>C (p.Y211H) is a novel benign SNP and c.1628A>T (p.N543I) is the disease-causing mutation in urofacial syndrome.
Studies indicate that cathepsin L (show CTSL1 Antibodies) as the heparanase (show HPSE Antibodies) activating protease.
These results indicate a regulatory effect of heparanase (show HPSE Antibodies) on TFPI (show TFPI Antibodies) and TFPI-2 (show TFPI2 Antibodies) in trophoblasts, suggesting a potential involvement of heparanase (show HPSE Antibodies) in early miscarriages.
We now report evidence that Heparanse 2 (HPSE2) is the culprit gene for the syndrome. Mutations with a loss of function in the Heparanase 2 (HPSE2) gene
Homozygous exonic deletions, nonsense mutations, and frameshift mutations in five further unrelated families confirmed HPSE2 as the causative gene for UFS
Results demonstrated that the effectors from heparanase peptide-immunized mice could effectively lyse various tumor cells that were heparanase positive and HLA-A*0201 matched.
Deletion of Hpse2 cause the urofacial syndrome-like phenotype in mice.
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.
, heparanase 3
, heparanase-like protein
, inactive heparanase-2