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Hexosaminidase A Proteins (HEXA)

HEXA encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Additionally we are shipping Hexosaminidase A Antibodies (107) and Hexosaminidase A Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HEXA 15211 P29416
Rat HEXA HEXA 300757 Q641X3
HEXA 3073 P06865
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Top Hexosaminidase A Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
$492.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$816.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,234.00
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,234.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details

HEXA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
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Human , , ,
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Top referenced Hexosaminidase A Proteins

  1. Human Hexosaminidase A Protein expressed in Baculovirus infected Insect Cells - ABIN2004990 : Norflus, Yamanaka, Proia: Promoters for the human beta-hexosaminidase genes, HEXA and HEXB. in DNA and cell biology 1996 (PubMed)
    Show all 5 references for ABIN2004990

  2. Human Hexosaminidase A Protein expressed in Escherichia coli (E. coli) - ABIN1098761 : Nakano, Muscillo, Ohno, Hoffman, Suzuki: A point mutation in the coding sequence of the beta-hexosaminidase alpha gene results in defective processing of the enzyme protein in an unusual GM2-gangliosidosis variant. in Journal of neurochemistry 1988 (PubMed)

More Proteins for Hexosaminidase A (HEXA) Interaction Partners

Mouse (Murine) Hexosaminidase A (HEXA) interaction partners

  1. Neu4 (show NEU4 Proteins) is not the only sialidase contributing to the metabolic bypass in Hexa(-/-) mice.

Human Hexosaminidase A (HEXA) interaction partners

  1. reports a new missense mutation in the HEXA gene in two German siblings with late-onset Tay-Sachs disease and prominent psychiatric symptoms

  2. The silencing of the HEXA gene had a stronger immune inhibitory effect, thereby indicating a major involvement of beta-N-acetyl-hexosaminidase A isoenzyme within this mechanism.

  3. Human prostate cancer cells are characterised by a significant decrease in HexA activity.

  4. DNA reveals novel mutations in Iranian subjects causing Tay-Sachs disease in the alpha and beta subunits of HexA.

  5. GM2 (show CYB5D2 Proteins) gangliosidosis is caused by the gene mutation. (review)

  6. identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB (show HEXB Proteins) gene, and attempted to correlate these mutations with the clinical presentation of the patients

  7. HEXA gene in Argentinean patients affected with Tay-Sachs disease, overall 14 different mutations were identified, 8 of them were novel and lead to premature stop codons, drastic residues changes or a splicing defect.

  8. Beta-hexosaminidase over-expression affects lysosomal glycohydrolases expression and glycosphingolipid metabolism in mammalian cells.

  9. We report the first Jordanian Arab Tay-Sachs disease patient diagnosed by deficient beta-hexosaminidase A activity, mutation analysis revealed homozygosity for a nonsense HEXA mutation, c.78G>A (p.W26X)

  10. Down-regulation of beta-N-acetyl-D-glucosaminidase increases Akt1 (show AKT1 Proteins) activity in thyroid anaplastic cancer cells

Cow (Bovine) Hexosaminidase A (HEXA) interaction partners

  1. SNPs in the HEXA region on chromosome 10 have a protective effect against Bovine spongiform encephalopathy.

Hexosaminidase A (HEXA) Protein Profile

Protein Summary

This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

Gene names and symbols associated with Hexosaminidase A Proteins (HEXA)

  • hexosaminidase A (alpha polypeptide) (HEXA)
  • hexosaminidase A (alpha polypeptide) (hexa)
  • hexosaminidase A (LOC100228061)
  • hexosaminidase A (Hexa)
  • DKFZp459O0432 protein
  • fc04h11 protein
  • Hex-1 protein
  • HEXA protein
  • si:dkey-35i22.2 protein
  • TSD protein
  • wu:fc04h11 protein
  • wu:fv09f06 protein

Protein level used designations for Hexosaminidase A Proteins (HEXA)

beta-hexosaminidase subunit alpha , beta-hexosaminidase subunit beta , beta-hexosaminidase alpha chain , hexosaminidase A (alpha polypeptide) , beta-hexosaminidase alpha-subunit , hexosaminidase A , Beta-hexosaminidase alpha chain , N-acetyl-beta-glucosaminidase subunit alpha , beta-N-acetylhexosaminidase subunit alpha , hexosaminidase subunit A , Hexose aminidase A (alpha polypeptide) , hexosaminidase A alpha

GENE ID SPECIES
100145856 Ovis aries
100063584 Equus caballus
323613 Danio rerio
415320 Gallus gallus
748732 Pan troglodytes
100008950 Oryctolagus cuniculus
100302663 Pongo abelii
100195429 Salmo salar
100228061 Taeniopygia guttata
15211 Mus musculus
300757 Rattus norvegicus
3073 Homo sapiens
504468 Bos taurus
487633 Canis lupus familiaris
100142664 Sus scrofa
100438794 Pongo abelii
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