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Hexosaminidase B (Beta Polypeptide) (HEXB) ELISA Kits

Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Additionally we are shipping HEXB Antibodies (49) and HEXB Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HEXB 15212 P20060
HEXB 294673 Q6AXR4
HEXB 3074 P07686
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Top HEXB ELISA Kits at antibodies-online.com

Showing 5 out of 20 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.055 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$663.16
Details
Mouse 0.118 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$682.11
Details
Rat 0.59 ng/mL 1.56-100 ng/mL 96 Tests Log in to see 9 to 11 Days
$720.00
Details
Chicken
  96 Tests Log in to see 16 to 21 Days
$999.43
Details
Pig
  96 Tests Log in to see 11 to 13 Days
$1,029.60
Details

More ELISA Kits for HEXB Interaction Partners

Mouse (Murine) Hexosaminidase B (Beta Polypeptide) (HEXB) interaction partners

  1. mast cell granule beta-hexosaminidase (show HEXA ELISA Kits) is crucial for defense against bacterial invasion, but is not involved in the allergic response. the bactericidal mechanism of beta-hexosaminidase (show HEXA ELISA Kits) involves degradation of bacterial cell wall peptidoglycan.

  2. transgenic inducible strains of Sandhoff disease mice provide a dynamic platform with which to explore the pathophysiological sequelae immediately after loss of neuronal lysosomal beta-hexosaminidase (show HEXA ELISA Kits) activity.

  3. Data suggest that pathogenesis of Sandhoff disease (heritable beta-hexosaminidase (show HEXA ELISA Kits) deficiency) involves an increase in macrophage-inflammatory protein 1alpha (show CCL3 ELISA Kits) that induces monocytes to infiltrate the CNS and trigger neuronal apoptosis.

  4. The bicistronic beta-hexosaminidase (show HEXA ELISA Kits) vector can reverse the biochemical defects and down-stream consequences in Sandhoff neurons, reinforcing its potential for Sandhoff disease in vivo gene therapy.

  5. Beta-hexosaminidase (show HEXA ELISA Kits) is a peptidoglycan hydrolase that surprisingly exerts its mycobactericidal effect at the macrophage plasma membrane during mycobacteria-induced secretion of lysosomes

  6. There was no change in the level of GM2 (show CYB5D2 ELISA Kits) storage and pro-apoptotic activity or astrocyte activation in HexB-/- knockout mice

  7. Mannose receptor (-/-) liver sinusoidal endothelial cells had markedly and significantly reduced enzyme activities for four out of five lysosomal enzymes tested, i.e., cathepsin-D, alpha-mannosidase, beta-hexosaminidase and arylsulfatase.

Human Hexosaminidase B (Beta Polypeptide) (HEXB) interaction partners

  1. The absence of beta-N-acetyl-hexosaminidase activity does not alter the differentiation of i-DCs from HSCs, but it is critical for the activation of CD4 (show CD4 ELISA Kits)(+)T cells because knock-down of HEXA (show HEXA ELISA Kits) or HEXB gene causes a loss of function of i-DCs.

  2. A total of 19 HEXB variants were found in the 1092 genomes of which 5 are suspected of having a deleterious effect on hexosaminidase activity.

  3. DNA from Iranian Tay-Sachs patients reveals a novel mutation in HEXB predicting a termination codon or nonsense mutation.

  4. A patient with Sandhoff disease also is found to have a compound macro-deletion in HEXB.

  5. GM2 (show CYB5D2 ELISA Kits) gangliosidosis is caused by the gene mutation. (review)

  6. A highly significant correlation of HEX (show HHEX ELISA Kits)-7 and %CDT has been found. Because of exclusion of the P isoform, HEX (show HHEX ELISA Kits)-7 could be a useful supplementary marker for detecting chronic alcohol abuse.

  7. Expression of beta-hexosaminidase (show HEXA ELISA Kits) in the neurons of Sandhoff disease patients rescues transgenic mice from neurodegeneration.

  8. minigene studies revealed the presence of a novel alternative spliced HEXB mRNA variant also present in normal cells

  9. Characterization of seven novel mutations on the HEXB gene in French Sandhoff patients.

  10. identified 27 different mutations, 14 of which were novel, in the HEXA (show HEXA ELISA Kits) gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and attempted to correlate these mutations with the clinical presentation of the patients

HEXB Antigen Profile

Antigen Summary

Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II).

Gene names and symbols associated with HEXB

  • hexosaminidase B (Hexb) antibody
  • hexosaminidase B (beta polypeptide) (HEXB) antibody
  • ENC-1AS antibody

Protein level used designations for HEXB

N-acetyl-beta-glucosaminidase subunit beta , beta-N-acetylhexosaminidase subunit beta , beta-hexosaminidase subunit beta , hexosaminidase subunit B , HCC-7 , cervical cancer proto-oncogene 7 protein , beta-N-acetylhexosaminidase beta subunit , beta-hexosaminidase beta subunit , 65 kDa epididymal boar protein

GENE ID SPECIES
15212 Mus musculus
294673 Rattus norvegicus
3074 Homo sapiens
493928 Felis catus
396958 Sus scrofa
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